Results 81 to 90 of about 15,466,885 (336)

Evaluation of The Correlation and Reproducibility between Histamine, IL-4, and IL-13 Release from Human Basophils

Iranian Journal of Allergy, Asthma and Immunology, 2014
Human  basophils play a key role in allergic diseases such as asthma and in a variety of  immunological disorders.  The  generation  of  IL-4  and  IL-13  can  be  induced  from basophil  by  IgE-mediated   and   non-IgE-mediated   mechanisms.
Nahid Eskandari, Reza Bastan, Maryam Ahmadi, Peter T Peachell   +3 more
doaj  

miR-142-5p and miR-130a-3p are regulated by IL-4 and IL-13 and control profibrogenic macrophage program

Nature Communications, 2015
Macrophages play a pivotal role in tissue fibrogenesis, which underlies the pathogenesis of many end-stage chronic inflammatory diseases. MicroRNAs are key regulators of immune cell functions, but their roles in macrophage’s fibrogenesis have not been ...
Shicheng Su, Qiyi Zhao, Chonghua He, Di Huang, Jiang Liu, Fei Chen, Jianing Chen, Jian-You Liao, X. Cui, Yunjie Zeng, H. Yao, F. Su, Qiang Liu, Shanping Jiang, Erwei Song   +14 more
semanticscholar   +1 more source

IL‐4 induces proliferation in prostate cancer PC3 cells under nutrient‐depletion stress through the activation of the JNK‐pathway and survivin up‐regulation [PDF]

, 2012
Interleukin (IL)‐4 plays a critical role in the regulation of immune responses and has been detected at high levels in the tumor microenvironment of cancer patients where it correlates with the grade of malignancy.
Alva, Ajjai S., Craig, Matthew J., Czarnieski, Paul, Daignault, Stephanie D., Fuller, David, Healy, Patrick N., Hernandez, James, Pienta, Kenneth J., Roca, Hernan, Varsos, Zachary S., Ying, Chi   +10 more
core   +1 more source

Stereotactic Body Radiation Therapy for Pediatric, Adolescent, and Young Adult Patients With Osteosarcoma: Local Control Outcomes With Dosimetric Analysis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background/Objectives Osteosarcoma is a radioresistant tumor that may benefit from stereotactic body radiation therapy (SBRT) for locoregional control in metastatic/recurrent disease. We report institutional practice patterns, outcomes, toxicity, and failures in osteosarcoma patients treated with SBRT.
Jenna Kocsis, Shauna R. Campbell, Jonathan Jang, Eashwar Somasundaram, Chandana A. Reddy, Jacob G. Scott, Lilyana Angelov, Peter M. Anderson, Matteo Trucco, Zachary Burke, Lukas Nystrom, Nathan Mesko, Anthony Magnelli, Erin S. Murphy   +13 more
wiley   +1 more source

Interleujin 13: a new cytokin with properties similar to those of interleukin 4 Interleuquina 13: una nueva citoquina con propiedades similares a la interleuquina 4

Iatreia, 1995
<p class="MsoNormal"><span style="font-size: 9pt; font-family: Arial">Interleukln 13 (IL-13) is a recently discovered cytokine produced by TH2 Iymphocytes. Its most important physiological activity relates with suppression of Inflammatory and
Leonardo Vargas
doaj  

Lifestyle Behaviors and Cardiotoxic Treatment Risks in Adult Childhood Cancer Survivors

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Higher doses of anthracyclines and heart‐relevant radiotherapy increase cardiovascular disease (CVD) risk. This study assessed CVD and CVD risk factors among adult childhood cancer survivors (CCSs) across cardiotoxic treatment risk groups and examined associations between lifestyle behaviors and treatment risks.
Ruijie Li, Raquel Revuelta Iniesta, Alan R. Barker, Dimitris Vlachopoulos, Tomáš Sláma, Christina Schindera, Fabiën N. Belle   +6 more
wiley   +1 more source

Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity. [PDF]

, 1996
Reversible airway hyperreactivity underlies the pathophysiology of asthma, yet the precise mediators of the response remain unclear. Human studies have correlated aberrant activation of T helper (Th) 2-like effector systems in the airways with disease. A
Corry, DB, Erle, DJ, Folkesson, HG, Locksley, RM, Matthay, MA, Warnock, ML, Wiener-Kronish, JP   +6 more
core  

Cerebrospinal Fluid Liquid Biopsy Enables Targeted Therapy Without Tissue Diagnosis in Pediatric Low‐Grade Gliomas With BRAF V600E Mutation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT We present two pediatric cases of pediatric low‐grade gliomas (PLGG) with BRAF V600E mutations diagnosed and monitored using cerebrospinal fluid (CSF) liquid biopsy analyzed via digital droplet PCR (ddPCR), without tissue biopsy. Both patients were treated with dabrafenib and trametinib and monitored through clinical assessments, magnetic ...
Hannah Sultan, Damien Faury, Alexander G. Weil, Harrison J. Westwick, Nada Jabado, Sébastien Perreault   +5 more
wiley   +1 more source

IL-4 impairs wound healing potential in the skin by repressing fibronectin expression [PDF]

, 2017
BACKGROUND: Atopic dermatitis (AD) is characterized by intense pruritis and is a common childhood inflammatory disease. Many factors are known to affect AD development, including the pleiotropic cytokine IL-4.
Bozdogan, Gunseli, Goenka, Shreevrat, Kaplan, Mark H., Krishnamurthy, Purna, Nalepa, Grzegorz, Potchanant, Elizabeth A Sierra, Sehra, Sarita, Serezani, Ana PM, Spandau, Dan F., Turner, Matthew J., Walsh, Daniel   +10 more
core   +2 more sources

Changes in Body Composition in Children and Young People Undergoing Treatment for Acute Lymphoblastic Leukemia: A Systematic Review and Meta‐Analysis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Ongoing evidence indicates increased risk of sarcopenic obesity among children and young people (CYP) with acute lymphoblastic leukemia (ALL), often beginning early in treatment, persisting into survivorship. This review evaluates current literature on body composition in CYP with ALL during and after treatment.
Lina A. Zahed, Raquel Revuelta Iniesta, Mary Fewtrell, Julie Lanigan, Breeana Gardiner, Graeme O'Connor   +5 more
wiley   +1 more source