Critical role of NKT cells in posttransplant alloantibody production [PDF]
, 2014 We previously reported that posttransplant alloantibody production in CD8-deficient hosts is IL-4+ CD4+ T cell-dependent and IgG1 isotype-dominant. The current studies investigated the hypothesis that IL-4-producing natural killer T cells (NKT cells ...
Abdel-Rasoul, M. +7 more
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Data Science Education in U.S. Informal Learning Environments: A Review of the Literature
Journal of Statistics and Data Science EducationThis systematic review examines data science education in United States informal learning environments through analysis of 20 studies. Our analysis reveals the landscape of this emerging field.
Marc T. Sager +2 more
doaj +1 more source
Association of proinflammatory cytokines and chemotherapy-associated cognitive impairment in breast cancer patients: a multi-centered, prospective, cohort study. [PDF]
, 2015 BackgroundExisting evidence suggests that proinflammatory cytokines play an intermediary role in postchemotherapy cognitive impairment. This is one of the largest multicentered, cohort studies conducted in Singapore to evaluate the prevalence and ...
Ang, SF +19 more
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The potential role of T-cells and their interaction with antigen-presenting cells in mediating immunosuppression following trauma-hemorrhage [PDF]
, 2009 Objective: Trauma-hemorrhage results in depressed immune responses of antigen-presenting cells (APCs) and T-cells. Recent studies suggest a key role of depressed T-cell derived interferon (IFN)-g in this complex immune cell interaction.
Abraham E. +15 more
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Cytokines in Allergic Conjunctivitis: Unraveling Their Pathophysiological Roles
LifeAllergic conjunctivitis is one of the common immune hypersensitivity disorders that affect the ocular system. The clinical manifestations of this condition exhibit variability contingent upon environmental factors, seasonal dynamics, and genetic ...
DeGaulle I. Chigbu +3 more
doaj +1 more source
Neutralizing monoclonal antibodies define two different functional sites in human interleukin-4 [PDF]
, 1994 Human interleukin-4 (IL-4) is a small four-helix-bundle protein which is essential for organizing defense reactions against macroparasites, in particular helminths.
Arnold, S. +5 more
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Immunological relationships during primary infection with Heligmosomoides polygyrus (Nematospiroides dubius): downregulation of specific cytokine secretion (IL-9 and IL-10) correlates with poor mastocytosis and chronic survival of adult worms [PDF]
, 1993 Mice were infected either with Trichinella spiralis (day 0), Heligmosomoides polygyrus (day -14) or concurrently with both species and were killed in groups, together with naive control mice, on 2 occasions (day 8 and 15 post infection with T.
Behnke, Jerzy M. +5 more
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Interferon gamma (IFN -gamma) and interleukin -4 (IL-4) gene variants and cytokine levels in pulmonary tuberculosis. Indian Journal of Medical Research [PDF]
, 2006 Background & objectives: Cytokine gene polymorphisms may alter Th1/Th2 balance with major implications in tuberculosis. The aim of our study was to find out whether Interferon +874A and IL-4 -590T polymorphisms were associated with susceptibility to ...
Adhilakshmi, A R +5 more
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Increased IL-6 and IL-4 in exhaled breath condensate of patients with nasal polyposis. [PDF]
, 2009 BACKGROUND AND AIM: Nasal polyposis (NP) occurs in about 1-4% of the worldwide population. Increased plasma concentrations of different pro-inflammatory cytokines have been observed in NP, and might be related to the pathogenesis of this syndrome.
Barbaro, M. P. +7 more
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IL-4 induces the formation of multinucleated giant cells and expression of ?5 integrin in central giant cell lesion [PDF]
, 2016 It is now well established that IL-4 has a central role in the development of monocytes to multinucleated giant cells (MGCs) by inducing the expression of integrins on the surface of monocytes.
Aghbali, Amirala +5 more
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