Results 261 to 270 of about 1,374,412 (296)

The IL-4 receptor: biochemical characterization of IL-4-binding molecules in a T cell line expressing large numbers of receptors

The Journal of Immunology, 1991
Abstract Cross-linking of 125I-IL-4 to the surface of cells expressing IL-4R yields as the major IL-4-binding molecules, polypeptide chains with inferred m.w. of approximately 70,000 (p70) and approximately 120,000 to 140,000 (p120-p140). The demonstration that the functional product of the IL-4R cDNA clone has m.w.
A D, Keegan, M P, Beckmann, L S, Park, W E, Paul   +3 more
openaire   +2 more sources

IL-4-dependent up-regulation of IL-4 receptor expression in murine T and B cells

The Journal of Immunology, 1991
Abstract This study examined mRNA levels and cell surface expression of IL-4 receptor (IL-4R) in murine T and B cells after incubation with IL-4. Northern blot analysis of mRNA levels of T cells isolated from mesenteric lymph nodes and spleen revealed that IL-4 induced a transient augmentation of IL-4R mRNA in a dose-dependent manner.
H, Renz, J, Domenico, E W, Gelfand
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Association between genes encoding components of the IL-4/IL-4 receptor pathway and dermatitis in children

Gene, 2014
To determine whether IL-4, IL-4Rα and STAT6 polymorphisms are associated with susceptibility to dermatitis in Egyptian children.We genotyped three groups of children, consisting of 106 atopic dermatitis (AD) children, 95 non-AD children, and 100 of healthy controls, for IL-4 (-590 C/T), (-33 C/T), IL-4Rα (I50V), (Q576R) and STAT6 (2964 G/A), (2892 C/T)
Yousri M, Hussein, Sally M, Shalaby, Amani, Nassar, Saad S, Alzahrani, Ayman S, Alharbi, Maha, Nouh   +5 more
openaire   +2 more sources

Functional significance of IL-4 receptor on B cells in IL-4-induced human IgE production

Journal of Allergy and Clinical Immunology, 1995
IL-4 with the IgE-inducing activity is shown to upregulate the expression of IL-4 receptor (IL-4R) on lymphocytes. Antisense strategy was used that aimed at investigating the significance of IL-4-induced upregulation of IL-4R on B cells in human IgE production.
Y, Yanagihara, K, Ikizawa, K, Kajiwara, T, Koshio, Y, Basaki, K, Akiyama   +5 more
openaire   +2 more sources

An IL-4 receptor region containing an insulin receptor motif is important for IL-4-mediated IRS-1 phosphorylation and cell growth

Cell, 1994
Interleukin-4 (IL-4) treatment of 32D cells overexpressing insulin receptor substrate 1 (IRS-1) causes prompt tyrosine phosphorylation of IRS-1. Transfection of truncation mutants of the human IL-4 (huIL-4) receptor into 32D-IRS-1 cells demonstrated that the region from amino acid 437-557 is important for IL-4 signaling.
A D, Keegan, K, Nelms, M, White, L M, Wang, J H, Pierce, W E, Paul   +5 more
openaire   +2 more sources

Targeting of IL-4 and IL-13 receptors for cancer therapy

Cytokine, 2015
The Th2 cytokines, interleukin (IL)-4 and -13, are structurally and functionally related. They regulate immune responses and the immune microenvironment, not only under normal physiological conditions, but also in cancer. Both cytokines bind to their high-affinity receptors and form various configurations of receptor subtypes.
Akiko Suzuki, Pamela Leland, Bharat H. Joshi, Raj K. Puri   +3 more
openaire   +2 more sources

Efficacy of soluble IL-4 receptor for the treatment of adults with asthma

Journal of Allergy and Clinical Immunology, 2001
IL-4 mediates important proinflammatory functions in asthma, including induction of the IgE isotype switch, increased expression of vascular cell adhesion molecule 1 and promotion of eosinophil transmigration across the endothelium, stimulation of mucus production, and T(H)2 lymphocyte differentiation, leading to release of IL-4, IL-5, IL-9, and IL-13 ...
L C, Borish, H S, Nelson, J, Corren, G, Bensch, W W, Busse, J B, Whitmore, J M, Agosti   +6 more
openaire   +2 more sources

Expression of IL-4 Receptor on Human T and B Lymphocytes

Cellular Immunology, 1993
The expression of the interleukin-4 receptor on human blood and tonsil lymphocytes has been studied using a monoclonal antibody and high-sensitivity immunofluorescence flow cytometry. While no receptor expression could be detected on circulating or tonsil T cells, a subset of B cells was shown to express the receptor.
H, Zola, L, Flego, H, Weedon
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Signal transduction through the IL‐4 and insulin receptor families

STEM CELLS, 1995
Activation of tyrosine kinase-containing receptors and intracellular tyrosine kinases by ligand stimulation is known to be crucial for mediating initial and subsequent events involved in mitogenic signal transduction. Receptors for insulin and insulin-like growth factor 1 (IGF-1) contain cytoplasmic tyrosine kinase domains that undergo ...
L M, Wang, A, Keegan, M, Frankel, W E, Paul, J H, Pierce   +4 more
openaire   +2 more sources

Modulation of the immunoglobulin dysregulation in GvH- and SLE-like diseases by the murine IL-4 receptor (IL-4-R)

Inflammation Research, 1995
As has been reported previously, models of chronic graft-versus-host (GvH) and systemic lupus erythematosus (SLE)-like diseases are characterized by high IgE and IgG1 immunoglobulin (Ig) levels in the serum. An IL-4 induced pathological expansion of Th2 helper cells has been described for both disease models. Due to the immunopharmacological profile of
H U, Schorlemmer, G, Dickneite, E J, Kanzy, K H, Enssle   +3 more
openaire   +2 more sources