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Targeting of IL-4 and IL-13 receptors for cancer therapy

Cytokine, 2015
The Th2 cytokines, interleukin (IL)-4 and -13, are structurally and functionally related. They regulate immune responses and the immune microenvironment, not only under normal physiological conditions, but also in cancer. Both cytokines bind to their high-affinity receptors and form various configurations of receptor subtypes.
Akiko Suzuki +3 more
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Signal transduction through the IL‐4 and insulin receptor families

STEM CELLS, 1995
Activation of tyrosine kinase-containing receptors and intracellular tyrosine kinases by ligand stimulation is known to be crucial for mediating initial and subsequent events involved in mitogenic signal transduction. Receptors for insulin and insulin-like growth factor 1 (IGF-1) contain cytoplasmic tyrosine kinase domains that undergo ...
L M, Wang +4 more
openaire +2 more sources

Roles of IL-4, IL-13, and Their Receptors in Lung Cancer

Journal of Interferon & Cytokine Research
Interleukin (IL)-4 and IL-13 are the main effectors of innate lymphoid cells (ILC2) of the type 2 innate immune response, which can carry out specific signal transmission between multiple cells in the tumor immune microenvironment. IL-4 and IL-13 mediate signal transduction and regulate cellular functions in a variety of solid tumors through their ...
Yao Zhang +5 more
openaire +2 more sources

Il-4 and Il-4 receptors in human pregnancy tissues at term