Results 251 to 260 of about 1,374,412 (296)

Regulation of alloreactivity in vivo by IL-4 and the soluble IL-4 receptor

The Journal of Immunology, 1991
Abstract Although numerous in vitro studies have demonstrated that cytokines are involved in the generation of alloreactive effector cells, the role of these regulatory substances in vivo is less well defined. We have recently cloned and expressed cDNAs encoding both membrane bound and soluble forms of the murine IL-4R.
W C, Fanslow, K N, Clifford, L S, Park, A S, Rubin, R F, Voice, M P, Beckmann, M B, Widmer   +6 more
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The IL-4 Receptor — Signaling Mechanisms

1994
Interleukin-4 (IL-4) is a multifunctional cytokine that is a member of the hematopoietin family1. Its structure consists of a bundle of four left handed α helices in which the first and second and the third and fourth helices are connected by long over hand loops2,3,4,5.
A, Keegan, K, Nelms, W E, Paul
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Asthma and IL‐4 receptor alpha gene variants

European Journal of Immunogenetics, 2002
SummaryLinkage of allergy to chromosome 16 has been described in several studies, together with a positive association with interleukin 4 receptor α gene variants. Our aim was to replicate these findings in a sample of German and Swedish families recruited through sib‐pairs affected by bronchial asthma.
M, Wjst, S, Kruse, T, Illig, K, Deichmann   +3 more
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Atopy and the human IL-4 receptor α chain

Journal of Allergy and Clinical Immunology, 2000
Atopy is a common inherited disorder characterized by increased IgE responsiveness, but no functional analysis of the candidate genes related to atopy has been performed. IL-4 is important for B-cell production of IgE, and the human IL-4 receptor alpha chain (hIL-4Ralpha) is crucial for the binding and signal transduction of IL-4, so hIL-4Ralpha may be
K, Izuhara, Y, Yanagihara, N, Hamasaki, T, Shirakawa, J M, Hopkin   +4 more
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Specific Antagonism of Type I IL-4 Receptor with a Mutated Form of Murine IL-4

The Journal of Immunology, 1998
Abstract IL-4 is a pleiotropic cytokine that is essential for the differentiation of Th2 cells and is critically involved in the pathogenesis of certain infectious and allergic diseases. We have produced and functionally characterized a mutant of murine IL-4 (IL-4.Y119D) as a potential antagonist of IL-4. The analysis of IL-4R binding
M, Schnare, H, Blum, S, Jüttner, M, Röllinghoff, A, Gessner   +4 more
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CD28 Costimulation Accelerates IL-4 Receptor Sensitivity and IL-4-Mediated Th2 Differentiation

The Journal of Immunology, 1999
Abstract The development of Th1 and Th2 cells is determined by the type of antigenic stimulation involved in the initial cell activation step. Evidence indicates that costimulatory signals, such as those delivered by CD28, play an important role in Th2 development, but little is known about how CD28 costimulation contributes to Th2 ...
M, Kubo, M, Yamashita, R, Abe, T, Tada, K, Okumura, J T, Ransom, T, Nakayama   +6 more
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Upregulated expression of IL-4 receptors and increased levels of IL-4 in rheumatoid arthritis patients

Journal of Autoimmunity, 1995
The level of IL-4R expression on peripheral lymphocyte subsets from rheumatoid arthritis (RA) patients and controls was studied by flow cytometric analysis of the binding of phycoerythrin-labelled IL-4 (PE-IL-4). In normal lymphocytes, IL-4R is mainly expressed on CD19+ cells, although it was also seen, at lower levels, on CD3+, CD4+ and CD8+ cells. In
D, Rivas, L, Mozo, J, Zamorano, A, Gayo, J C, Torre-Alonso, A, Rodríguez, C, Gutiérrez   +6 more
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