Results 251 to 260 of about 18,323,172 (295)

Asthma and IL‐4 receptor alpha gene variants

European Journal of Immunogenetics, 2002
SummaryLinkage of allergy to chromosome 16 has been described in several studies, together with a positive association with interleukin 4 receptor α gene variants. Our aim was to replicate these findings in a sample of German and Swedish families recruited through sib‐pairs affected by bronchial asthma.
M, Wjst, S, Kruse, T, Illig, K, Deichmann   +3 more
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Atopy and the human IL-4 receptor α chain

Journal of Allergy and Clinical Immunology, 2000
Atopy is a common inherited disorder characterized by increased IgE responsiveness, but no functional analysis of the candidate genes related to atopy has been performed. IL-4 is important for B-cell production of IgE, and the human IL-4 receptor alpha chain (hIL-4Ralpha) is crucial for the binding and signal transduction of IL-4, so hIL-4Ralpha may be
K, Izuhara, Y, Yanagihara, N, Hamasaki, T, Shirakawa, J M, Hopkin   +4 more
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Specific Antagonism of Type I IL-4 Receptor with a Mutated Form of Murine IL-4

The Journal of Immunology, 1998
Abstract IL-4 is a pleiotropic cytokine that is essential for the differentiation of Th2 cells and is critically involved in the pathogenesis of certain infectious and allergic diseases. We have produced and functionally characterized a mutant of murine IL-4 (IL-4.Y119D) as a potential antagonist of IL-4. The analysis of IL-4R binding
M, Schnare, H, Blum, S, Jüttner, M, Röllinghoff, A, Gessner   +4 more
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CD28 Costimulation Accelerates IL-4 Receptor Sensitivity and IL-4-Mediated Th2 Differentiation

The Journal of Immunology, 1999
Abstract The development of Th1 and Th2 cells is determined by the type of antigenic stimulation involved in the initial cell activation step. Evidence indicates that costimulatory signals, such as those delivered by CD28, play an important role in Th2 development, but little is known about how CD28 costimulation contributes to Th2 ...
M, Kubo, M, Yamashita, R, Abe, T, Tada, K, Okumura, J T, Ransom, T, Nakayama   +6 more
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Upregulated expression of IL-4 receptors and increased levels of IL-4 in rheumatoid arthritis patients

Journal of Autoimmunity, 1995
The level of IL-4R expression on peripheral lymphocyte subsets from rheumatoid arthritis (RA) patients and controls was studied by flow cytometric analysis of the binding of phycoerythrin-labelled IL-4 (PE-IL-4). In normal lymphocytes, IL-4R is mainly expressed on CD19+ cells, although it was also seen, at lower levels, on CD3+, CD4+ and CD8+ cells. In
D, Rivas, L, Mozo, J, Zamorano, A, Gayo, J C, Torre-Alonso, A, Rodríguez, C, Gutiérrez   +6 more
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The IL-4 receptor: biochemical characterization of IL-4-binding molecules in a T cell line expressing large numbers of receptors

The Journal of Immunology, 1991
Abstract Cross-linking of 125I-IL-4 to the surface of cells expressing IL-4R yields as the major IL-4-binding molecules, polypeptide chains with inferred m.w. of approximately 70,000 (p70) and approximately 120,000 to 140,000 (p120-p140). The demonstration that the functional product of the IL-4R cDNA clone has m.w.
A D, Keegan, M P, Beckmann, L S, Park, W E, Paul   +3 more
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Association between genes encoding components of the IL-4/IL-4 receptor pathway and dermatitis in children

Gene, 2014
To determine whether IL-4, IL-4Rα and STAT6 polymorphisms are associated with susceptibility to dermatitis in Egyptian children.We genotyped three groups of children, consisting of 106 atopic dermatitis (AD) children, 95 non-AD children, and 100 of healthy controls, for IL-4 (-590 C/T), (-33 C/T), IL-4Rα (I50V), (Q576R) and STAT6 (2964 G/A), (2892 C/T)
Yousri M, Hussein, Sally M, Shalaby, Amani, Nassar, Saad S, Alzahrani, Ayman S, Alharbi, Maha, Nouh   +5 more
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IL-4-dependent up-regulation of IL-4 receptor expression in murine T and B cells

The Journal of Immunology, 1991
Abstract This study examined mRNA levels and cell surface expression of IL-4 receptor (IL-4R) in murine T and B cells after incubation with IL-4. Northern blot analysis of mRNA levels of T cells isolated from mesenteric lymph nodes and spleen revealed that IL-4 induced a transient augmentation of IL-4R mRNA in a dose-dependent manner.
H, Renz, J, Domenico, E W, Gelfand
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Functional significance of IL-4 receptor on B cells in IL-4-induced human IgE production

Journal of Allergy and Clinical Immunology, 1995
IL-4 with the IgE-inducing activity is shown to upregulate the expression of IL-4 receptor (IL-4R) on lymphocytes. Antisense strategy was used that aimed at investigating the significance of IL-4-induced upregulation of IL-4R on B cells in human IgE production.
Y, Yanagihara, K, Ikizawa, K, Kajiwara, T, Koshio, Y, Basaki, K, Akiyama   +5 more
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An IL-4 receptor region containing an insulin receptor motif is important for IL-4-mediated IRS-1 phosphorylation and cell growth

Cell, 1994
Interleukin-4 (IL-4) treatment of 32D cells overexpressing insulin receptor substrate 1 (IRS-1) causes prompt tyrosine phosphorylation of IRS-1. Transfection of truncation mutants of the human IL-4 (huIL-4) receptor into 32D-IRS-1 cells demonstrated that the region from amino acid 437-557 is important for IL-4 signaling.
A D, Keegan, K, Nelms, M, White, L M, Wang, J H, Pierce, W E, Paul   +5 more
openaire   +2 more sources