Results 91 to 100 of about 17,201,482 (284)

Sophoricoside analogs as the IL-5 inhibitors from sophora japonica

, 1999
Fruits of Sophora japonica L. (Leguminosae) exhibited an inhibitory effect in the IL-5 bioassay of mIL-5-dependent Y16 proliferation. The isoflavonoids of sophoricoside, genistein, orobol, and genistin were isolated as the IL-5 inhibitors from fresh ...
Kiyoshi Takatsu, Bok Gi Min, Sei Ryang Oh, Kyung Rak Min, Young Soo Kim, Il Moo Chang, Hyeong Kyu Lee   +6 more
core   +1 more source

Recent Developments in Monoclonal-Antibody-Based Biologic Therapy for Severe Refractory Eosinophilic Asthma

Antibodies
Background: Asthma exhibits marked heterogeneity both clinically and at the molecular phenotypic level, requiring specifically targeted treatments to block the key pathways of the disease.
Garry M. Walsh
doaj   +1 more source

Schopenhauer tra l’analogia e il solipsismo: L’apparente contraddizione tra il § 5 e il § 19 del "Mondo"

Voluntas, 2010
Come è noto, Schopenhauer afferma, nel paragrado 19 del Mondo come volontà e rappresentazione, che «l’egoismo teoretico non si potrà mai confutare con prove».
Alessandro Novembre
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Benralizumab in the treatment of severe asthma: design, development and potential place in therapy

Drug Design, Development and Therapy, 2018
Corrado Pelaia,1 Alessandro Vatrella,2 Andrea Bruni,1 Rosa Terracciano,3 Girolamo Pelaia1 1Department of Medical and Surgical Sciences, Section of Respiratory Diseases, “Magna Græcia” University of Catanzaro, Catanzaro, Italy ...
Pelaia C, Vatrella A, Bruni A, Terracciano R, Pelaia G   +4 more
doaj  

Human leukocyte antigen-G expression in differentiated human airway epithelial cells: lack of modulation by Th2-associated cytokines

Respiratory Research, 2013
Background Human leukocyte antigen (HLA)-G is a nonclassical class I antigen with immunomodulatory roles including up-regulation of suppressor T regulatory lymphocytes.
White Steven R, Loisel Dagan A, Stern Randi, Laxman Bharathi, Floreth Timothy, Marroquin Bertha A   +5 more
doaj   +1 more source

Structure and Function of IL-5 Receptor

YAKUGAKU ZASSHI, 1995
Interleukin-5 (IL-5) regulates the production and function of B cells, eosinophils and basophils. In particular, IL-5 plays a critical role in the development of CD5-positive B (B-1) cells. The pleiotropic activity of IL-5 on target cells is directly dependent on the initial binding to IL-5 specific cell-surface receptor (IL-5R).
openaire   +3 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Il questionario banche

, 2011
Il capitolo definisce un modello di business ideale per il microcredito individuando compiti e responsabilità dei diversi attori coinvolti (policy maker, operatori del microcredito, intermediari bancari, ecc..)The chapter defines an ideal business model
PORRETTA, Pasqualina
core