Results 121 to 130 of about 90,829,949 (240)
Mepolizumab treatment alters the functional phenotype of eosinophils in severe eosinophilic asthma
Frontiers in ImmunologyBackgroundBlood eosinophil count is usually employed as a predictive and response biomarker for mepolizumab treatment. However, its decrease is not always associated with an improvement in asthma symptoms.
Pablo Miguéns-Suárez +19 more
doaj +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Il quadro economico e produttivo in Europa
, 2015 Il contributo descrive la geografia produttivo-commerciale del settore tessile-abbigliamento, tassello importante dell’economia manifatturiera europea, che conta oltre 200.000 imprese e circa 1,6 milioni di addetti, che generano circa 5 milioni di posti ...
SIMONETTI, LUCIA
core
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Dopo il referendum costituzionale: quali prospettive per il sistema delle autonomie?
, 2016 Il contributo è una riflessione sulle prospettive di riforma del Titolo V della Parte II della Costituzione e del sistema delle autonomie regionali, dopo il voto contrario al referendum costituzionale del 4 dicembre 2016 sul progetto di riforma ...
MORELLI A.
core
'Spielen’ : il gioco teatrale e la misura dell’infanzia
, 2021 Il contributo riflette sulle implicazioni tra gioco, teatro, formazione nelle arti partendo dal termine 'Spiel', con riferimenti all'opera di Bruno Munari e alle sue implicazioni in ambito ...
C. Grazioli
core
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source