Results 211 to 220 of about 90,829,949 (240)
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IL‐5 and IL‐5 receptor alpha polymorphisms are associated with atopic dermatitis in Koreans
Allergy, 2007Background: Eosinophils are recruited into the affected tissue of asthma and atopic dermatitis (AD) patients. IL‐5 and IL‐5R are highly expressed in the AD skin lesions, yet the reported levels of IL‐8 are controversial.Method: We genotyped 17 singlenucleotide polymorphisms (SNPs) from five genes of the 1120 case‐control samples (646 AD and 474 ...
J-H, Namkung +7 more
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Effect of Anti-IL-5 and IL-5 on Airway Hyperreactivity and Eosinophils in Guinea Pigs
American Review of Respiratory Disease, 1993Abstract Chronic ovalbumin challenge of sensitized guinea pigs induces bronchoalveolar lavage (BAL) eosinophilia, neutrophilia, and tracheal hyperreactivity. In the present study, the influence of monoclonal antibody to murine interleukin-5 (anti-IL-5) on these phenomena is examined.
A J, Van Oosterhout +5 more
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Development of IL-5 Receptor Antagonists
Current Pharmaceutical Design, 2002A wealth of both clinical and pre-clinical data has strongly implicated the eosinophil in the pathogenesis of asthma, highlighting this cell type as a potential target for novel anti-inflammatory approaches to asthma therapy. The Th2 lymphocyte derived cytokine Interleukin-5 (IL-5) has emerged as the key regulator of eosinophil production, thus ...
Iain, Uings, Murray, McKinnon
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The mechanism of IL-5 signal transduction
American Journal of Physiology-Cell Physiology, 1998Cytokines are important regulators of hematopoiesis. They exert their actions by binding to specific receptors on the cell surface. Interleukin-5 (IL-5) is a critical cytokine that regulates the growth, activation, and survival of eosinophils. Because eosinophils play a seminal role in the pathogenesis of asthma and allergic diseases, an understanding
T, Adachi, R, Alam
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Biology of IL-5 in health and disease
Annals of Allergy, Asthma & Immunology, 1999Reading this article will increase the readers' knowledge of the biology of interleukin-5 (IL-5), an important cytokine. The immune and inflammatory responses of any organism are the basis of the defense mechanism ensuring its survival. The role of IL-5 in these processes, as well as in the pathogenesis of various diseases has been discussed along with
T, Lalani, R K, Simmons, A R, Ahmed
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Anti-IL-5 and hypereosinophilic syndromes
Clinical Immunology, 2005Hypereosinophilic syndromes represent a heterogeneous group of disorders characterized by peripheral eosinophilia and end-organ damage associated with eosinophil infiltrations. In many instances, the eosinophilia is refractory to standard therapies and clinicians rely on potentially toxic alternatives.
Steven A, Sutton +2 more
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Allergy
Eosinophilic asthma is characterized by frequent exacerbations, poor symptom control and accelerated lung function decline. It is now recognized that the immune response underlying eosinophilic asthma involves a complex network of interconnected pathways from both the adaptive and innate immune systems.
David J, Jackson +3 more
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Eosinophilic asthma is characterized by frequent exacerbations, poor symptom control and accelerated lung function decline. It is now recognized that the immune response underlying eosinophilic asthma involves a complex network of interconnected pathways from both the adaptive and innate immune systems.
David J, Jackson +3 more
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1995
Abstract The cDNA sequence for human and mouse (GenBank accession numbers X04688 and X06270) predict proteins of 134 and 133 amino acids, respectively. Sequence information is available for both the human and mouse genomic genes (GenBank accession numbers J02971 and XO6271).The coding sequence of the IL-5 gene forms four exons.
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Abstract The cDNA sequence for human and mouse (GenBank accession numbers X04688 and X06270) predict proteins of 134 and 133 amino acids, respectively. Sequence information is available for both the human and mouse genomic genes (GenBank accession numbers J02971 and XO6271).The coding sequence of the IL-5 gene forms four exons.
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Regulation of IL-5 expression.
Archivum immunologiae et therapiae experimentalis, 2002Interleukin 5 (IL-5) is a cytokine primarily involved in the pathogenesis of atopic diseases. It specifically controls the production, activation and localization of eosinophils, the major cause of tissue damage in atopic diseases. IL-5 belongs to a gene family shared by IL-3, IL-4 and granulocyte-macrophage colony-stimulating factor (GM-CSF) and is ...
V A, Mordvinov, C J, Sanderson
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