Results 91 to 100 of about 13,521,848 (335)

IL-6 pathway in the liver: From physiopathology to therapy.

Journal of Hepatology, 2016
Interleukin 6 (IL-6) is a pleiotropic four-helix-bundle cytokine that exerts multiple functions in the body. In the liver, IL-6 is an important inducer of the acute phase response and infection defense.
D. Schmidt-Arras, S. Rose-John
semanticscholar   +1 more source

The role of IL-6 for predicting neonatal sepsis: A systematic review and meta-analysis [PDF]

, 2011
Objective: Neonatal sepsis (NS) is a common and life-threatening disorder in infants. Previous studies showed that interleukin-6 (IL-6) may be a valid non-invasive and rapid method for diagnosis of NS.
Ahani, A., Keshtkar, A., Mirfazeli, A., Roshandel, G., Shahkar, L.   +4 more
core   +1 more source

Storage Conditions and Passages Alter IL-6 Secretion in C26 Adenocarcinoma Cell Lines [PDF]

, 2015
The C26 adenocarcinoma tumor line is frequently used to establish peripheral tumors in mice for the study of cancer cachexia and cancer-related fatigue. Recently, we have noticed a progressive decline in the effects of tumor growth on our biological and ...
Devine, Raymond, McCarthy, Donna O., Norden, Diana M., Wold, Loren E.   +3 more
core   +3 more sources

Transcriptomic profiling disclosed the role of DNA methylation and histone modifications in tumor-infiltrating myeloid-derived suppressor cell subsets in colorectal cancer [PDF]

, 2020
Increased numbers of myeloid-derived suppressor cells (MDSCs) are positively correlated with poor prognosis and reduced survivals of cancer patients. They play central roles in tumor immune evasion and tumor metastasis.
Abu Nada, M, Ahmed, AA, Alajez, NM, Elkord, E, Kurer, MA, Murshed, K, Saleh, R, Sasidharan Nair, V, Taha, RZ, Toor, SM   +9 more
core   +3 more sources

Improving the Evaluation and Management of Transfusion‐Related Iron Overload in Children, Adolescents, and Young Adults Following Cancer Treatment or Hematopoietic Stem Cell Transplantation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Transfusion‐related iron overload (TRIO) is a late effect of therapy impacting survivors of childhood cancer and hematopoietic stem cell transplantation (HSCT) who receive frequent packed red blood cell (pRBC) transfusions. Surprisingly, there are no accepted guidelines to assist providers in identifying and treating at‐risk ...
Luke Gingell, Allison Close, Guoli Zhou, Troy C. Quigg   +3 more
wiley   +1 more source

Understanding the Role of Interleukin-6 (IL-6) in the Joint and Beyond: A Comprehensive Review of IL-6 Inhibition for the Management of Rheumatoid Arthritis

Rheumatology and Therapy, 2020
Rheumatoid arthritis (RA) is a chronic, debilitating autoimmune disorder involving inflammation and progressive destruction of the joints, affecting up to 1% of the population.
E. Favalli
semanticscholar   +1 more source

Novel Genetic Risk Factor Identified for L‐Asparaginase‐Induced Pancreatitis in Pediatric Patients With Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background L‐asparaginase is a critical component in treatment protocols for pediatric acute lymphoblastic leukemia. Acute pancreatitis reactions can necessitate delays and, in some cases, discontinuation of L‐asparaginase, which compromises outcomes.
Edward J. Raack, Wan‐Chun Chang, Miguel Cordova‐Delgado, Spencer J. Anderson, Jessica N. Trueman, Erika N. Scott, Catrina M. Loucks, Shahrad R. Rassekh, Gabriella S. S. Groeneweg, Michelle Higginson, Kathy Li, Fudan Miao, Derek Yau, Donna Johnston, Mounira Ibrahim, Maja Krajinovic, Thai Hoa Tran, Jessica Tewfik, Jean‐François Bussières, Thaïna‐Rafi Jean‐Baptiste, Denis Lebel, Lucie Pecheux, Bina Gyawali, Gregory Guilcher, Gesche Riabowol, Geert ’t Jong, Michelle Staub, Geoff Cuvelier, Kathleen Felton, Sara Khalaj, Michael Rieder, Awatif Abuzgaia, Tamorah Lewis, Himal Ghimire, Paul Nathan, Kerry Goralski, Ketan Kulkarni, Zara Forbrigger, Colin J. D. Ross, Bruce C. Carleton   +39 more
wiley   +1 more source

Spotlight on tocilizumab and its potential in the treatment of systemic sclerosis

Drug Design, Development and Therapy, 2016
Lazaros I Sakkas Department of Rheumatology and Clinical Immunology, Medical School, University of Thessaly, Larissa, Greece Abstract: Systemic sclerosis (SSc) is a multisystem disease characterized by extensive collagen deposition in skin and internal
Sakkas LI
doaj  

RETRACTED: Rhodomyrtus tomentosa (Aiton) Hassk. (haramonting) protects against allethrin-exposed pulmo damage in rats: mechanistic interleukins

Frontiers in Pharmacology
Inhaling Allethrin (C19H26O3) may induce oxidative stress in lung cells by causing the formation of free radi-cals. Interleukins (IL) are a group of secreted cytokines or proteins and signaling molecules initially produced as an immune response by ...
Putri Cahaya Situmorang, Syafruddin Ilyas, Rony Abdi Syahputra, Alexander Patera Nugraha, Mimmy Sari Syah Putri, Cheryl Grace Pratiwi Rumahorbo   +5 more
doaj   +1 more source

Cytokine Secretion in Macrophages: SNAREs, Rabs and Membrane Trafficking.

Frontiers in Immunology, 2014
Macrophages have the capacity to rapidly secrete a wide range of inflammatory mediators that influence the development and extent of an inflammatory response.
Rachael Zoe Murray, Jennifer L Stow
doaj   +1 more source