Results 181 to 190 of about 1,128,932 (296)

Molecular Interactions of Viral Insulin/IGF‐Like Peptides With Zebrafish Receptors

open access: yesProteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Signaling through the insulin receptor (IR) and the type 1 insulin‐like growth factor receptor (IGF1R) is modulated by secreted hormones and growth factor ligands (e.g., insulin and insulin‐like growth factor 1, IGF1). Impaired signaling in these receptors often leads to diabetes and oncogenic diseases.
Lev Levintov, Harish Vashisth
wiley   +1 more source

Method for the Determination of Dynamic Domains in Proteins From Structural Pairs and Conformational Ensembles

open access: yesProteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT A straightforward method for the determination of dynamic domains from pairs of conformations or general conformational ensembles of proteins is presented. The method applies metric multi‐dimensional scaling (MDS) to distance‐differences or root‐mean square‐fluctuations of inter‐atomic distances (RMSFIDs).
Steven Hayward
wiley   +1 more source

Antiplasmodial Activity of Methylangolensate From <i>Entandrophragma angolense</i> (Welw.) C.DC. Stem Bark: An In Vitro and In Silico Approach. [PDF]

open access: yesJ Trop Med
Tetteh J   +8 more
europepmc   +1 more source

From knowledge to action: the importance of characterizing herbicide resistance mechanisms for implementing management strategies

open access: yesPest Management Science, EarlyView.
This review bridges the gap between understanding resistance mechanisms and applying them in weed management, highlighting how mechanistic insights reveal vulnerabilities that can guide more effective control strategies. Abstract Herbicide resistance remains one of the most intensively studied areas in weed science because of its direct consequences ...
Luan Cutti   +3 more
wiley   +1 more source

Transcriptome Inference and Systematic Approaches to Investigate TCM Compounds With Beneficial Metabolic Effects

open access: yesPhytotherapy Research, EarlyView.
ABSTRACT Obesity is a major risk factor for type 2 diabetes. Some traditional Chinese medicine (TCM) compounds can improve obesity by increasing energy consumption. This study aimed to identify and verify TCM compounds that promote adipose thermogenesis to alleviate obesity via transcriptomic analysis, molecular docking, network pharmacology, and ...
Jing Li   +6 more
wiley   +1 more source

Distinguishing Ile/Leu Variant Ligands in the Immunopeptidome Using Hybrid EAD + CID Fragmentation (ExCID). [PDF]

open access: yesAnal Chem
Dorvash M   +9 more
europepmc   +1 more source

Peptide‐based antibacterial nanoplatforms: Design principles, stimuli‐regulated behaviors, and applications

open access: yesResponsive Materials, EarlyView.
Peptide‐based antibacterial nanoplatforms, encompassing self‐assembled peptides and peptide‐engineered inorganic, polymeric, and lipid nanocarriers, are systematically reviewed. The article highlights design principles and stimuli‐responsive regulation for improving peptide stability, delivery efficiency, and antibacterial performance.
Peng Tan   +8 more
wiley   +1 more source

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