Results 201 to 210 of about 731,570 (316)

Anticipating tomorrow: The role of corporate foresight and prospective sensemaking in managing digital changes by established organizations

European Management Review, EarlyView.
Abstract In the digital era, established organizations face significant challenges in adapting to unfolding changes. This study explores the reciprocal relationship between prospective sensemaking and corporate foresight within a large European bank engaged in digital transformation through its corporate accelerator program.
Anna‐Sofia Yanson, Mohamad Najib Tarhini, Daniele Cerrato   +2 more
wiley   +1 more source

A novel JK-null allele due to splicing variant. [PDF]

Transfusion
Tournamille C, Fichou Y, Benech C, Muralitharan V, Levy C, Heng E, Bouly N, Floch A.   +7 more
europepmc   +1 more source

A new branch of mammalian vitamin B6 metabolism: AKR1C‐mediated conversion of pyridoxal to pyridoxine and 4‐pyridoxolactone

The FEBS Journal, EarlyView.
Pyridoxal 5′‐phosphate (PLP) homeostasis relies on salvage enzymes, yet key metabolic branches remain undefined. We identify AKR1C isozymes as previously undescribed contributors that convert pyridoxal into pyridoxine or 4‐pyridoxolactone through reductase and dehydrogenase activities.
Nayu Kito, Yasuyuki Kitaura, Kyoka Iino, Kazuya Toriumi, Hyunah Noh, Naoya Ogawa, Makoto Arai, Hisashi Hemmi, Tomokazu Ito   +8 more
wiley   +1 more source

Discovery of novel InhA inhibitors through structural bioinformatics and machine learning-driven QSAR screening of natural products. [PDF]

Biol Methods Protoc
Anthony GI, Nwosu SN, Owolade AJ, Kehinde TO, Teye RG, Akor SE, Fabuyi FS, Nwafor IR, Oleh PK, Ilori TD, Bodun DS.   +10 more
europepmc   +1 more source

Functional characterization of 42 CK2α de novo variants associated with Okur‐Chung neurodevelopmental syndrome

The FEBS Journal, EarlyView.
Okur‐Chung neurodevelopmental syndrome (OCNDS) is a neurodevelopmental disorder associated with mutations in the gene coding for Protein kinase CK2α. In this work, 42 variants of CK2α associated with OCNDS were characterized in vitro. This included determination of catalytic activity and CK2α/CK2β‐interaction as well as an assessment of evolutionary ...
Alexander Gast, Christian Werner, Karsten Niefind, Joachim Jose   +3 more
wiley   +1 more source

Gut microbiota dysbiosis induced by tibial dyschondroplasia in turn accelerates disease pathogenesis through the gut-bone axis in broilers. [PDF]

Poult Sci
Song H, Wang J, Hao Y, Li X, Yan S, Han S, Zhao J, Han Y, Sun S, Chen X, Purba MA, Chen H, Li C.   +12 more
europepmc   +1 more source

A distinct gene expression mechanism for d‐amino acid utilization in hyperthermophilic archaeon Pyrococcus horikoshii

The FEBS Journal, EarlyView.
The genes PH0137, PH0138, and PH0140 form a cluster in the genome of Pyrococcus horikoshii. The PH0140 gene encodes a transcription factor identified as a d‐amino acid‐responsive regulatory protein (DARP). In feast mode, l‐Ile‐bound DARP binds to the promoter and represses transcription of PH0137 and PH0138. In famine mode, DARP binds to d‐allo‐Ile and
Ryushi Kawakami, Tomoki Kawase, Taira Uehara, Haruhiko Sakuraba, Tomohiko Matsuzawa, Junji Hayashi, Toshihisa Ohshima   +6 more
wiley   +1 more source

Construction of Escherichia coli L-isoleucine cell factories based on propionate pathway. [PDF]

J Biol Eng
Xiao Y, Li X, Jiang L, Zhao Y, Wang L, Feng Y.   +5 more
europepmc   +1 more source

Economic Approaches to the Separation of Powers

This chapter surveys economic perspectives on the separation of powers, revealing how contemporary research in political economics and the economic analysis of law conceptualize and assess institutional checks on government authority.
Voigt, Stefan, Gutmann, Jerg
core  

Molecular dynamics simulations elucidate the misfolding mechanisms of secretion‐defective pancreatic lipase variants

The FEBS Journal, EarlyView.
Misfolding mutations in pancreatic lipase have been identified as potential contributors of chronic pancreatitis, an inflammatory disease of the human pancreas. Here, we describe the effect of these misfolding mutations on pancreatic lipase structure using molecular dynamics simulations and structural modeling.
Gyula Hoffka, András Szabó
wiley   +1 more source