Results 41 to 50 of about 1,128,932 (296)

Pedagogía institucionista y educación social en Castilla y León

open access: yesHistoria de la Educación, 2013
El presente trabajo de investigación historiográfica sobre el desarrollo e influencia del institutucionismo pedagógico en Castilla y León ha pretendido hacer hincapié en dos coordenadas generales.
Leoncio VEGA GIL
doaj  

IL-23 and IL-17 in tuberculosis [PDF]

open access: yesCytokine, 2008
Tuberculosis is a chronic disease requiring the constant expression of cellular immunity to limit bacterial growth. The constant expression of immunity also results in chronic inflammation, which requires regulation. While IFN-gamma-producing CD4+ T helper cells (Th1) are required for control of bacterial growth they also initiate and maintain a ...
Shabaana A, Khader, Andrea M, Cooper
openaire   +2 more sources

Lignin Mimicking Protein Methylation Augments the Efficacy of FOLFOX Chemotherapy by Anchoring Thymidylate Synthase

open access: yesAdvanced Materials, EarlyView.
Lignin‐mimicking protein methylation can enhance the efficacy and mitigate the toxicity of the classic FOLFOX chemotherapy regimen. ABSTRACT FOLFOX has served as the standard chemotherapy regimen for advanced stages, specifically in the treatment of pancreatic, colorectal, and bladder cancers.
Shiyao Song   +14 more
wiley   +1 more source

OECD Ülkelerinin Bazı Makroekonomik Değişkenleri ile Petrol Fiyatları Arasındaki Nedensellik İlişkileri için Panel Veri Analizi [PDF]

open access: yes, 2020
Son yıllarda ülkelerin makroekonomik göstergeleri ve dünya ham petrol fiyatlarındaki değişmeler arasındaki ilişkilerin incelenmesi önem arz etmektedir. Bu çalışmada; seçilen 31 OECD ülkesinde 2003-2018 dönemi için ekonomik büyüme, enflasyon ve ham petrol
Ergin, Nursefa, Türkyılmaz, Serpil
core   +1 more source

Ultrasound‐Activated Piezoelectric Neuroimmune Hydrogel Orchestrates Neurogenesis‐Macrophage Crosstalk in Diabetic Wound Healing

open access: yesAdvanced Science, EarlyView.
In this work, we design an ultrasound‐activated piezoelectric hydrogel platform (AOEF@AP5+US) that reprograms neurogenesis‐macrophage crosstalk as an integrated strategy to overcome the intertwined barriers of chronic inflammation, peripheral neuropathy, and impaired regeneration in diabetic wounds.
Kai Wang   +13 more
wiley   +1 more source

Innovative Test Strip‐Based Colorimetric Sensors Integrated With Affinity Chromatography: Acetylcholinesterase Inhibitor Screening Breakthrough in Lycium Barbarum Leaves

open access: yesAdvanced Science, EarlyView.
Schematic diagrams illustrating the breakthrough in the screening of AChE inhibitors from LBL, and the research process of the pharmacodynamics of the NCP are presented. ABSTRACT Current Alzheimer's drugs exhibit limited effectiveness, highlighting the necessity for multi‐target treatments.
Yuping Sa   +11 more
wiley   +1 more source

Beyond Nature's Blueprint: Macrocyclic Peptides Containing Unnatural Amino Acids in Therapeutic Development

open access: yesAngewandte Chemie, EarlyView.
Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma   +5 more
wiley   +2 more sources

La institución libre de enseñanza y la arquitectura escolar

open access: yesHistoria de la Educación, 2013
El modelo educativo de la ILE adopta pautas pedagógicas alternativas en el espacio y el tiempo. La arquitectura escolar no es un accesorio en su propuesta pedagógica.
Francisco Javier RODRÍGUEZ MÉNDEZ
doaj  

Traveling for Medical Tourism - The Diaspora' s Motivation [PDF]

open access: yesCactus, 2017
Medical tourism, considered the newest phenomena but, as well, an old activity of travelling on health purposes, is increasingly more often the subject of articles, seminars or conferences.
Florența Larisa Vasile (Ile)
doaj  

TED1 Promotes the Assembly of SCFD3‐D14‐D53 to Reinforce Strigolactone Signaling in Rice

open access: yesAdvanced Science, EarlyView.
This study identifies TED1 as a positive regulator of strigolactones (SL) signaling in rice. The ted1 mutants display dwarfism and increased tillering with significantly reduced SLs sensitivity. Through its longer C‐terminal region, TED1 interacts with D53 and D14 to promote the assembly of SCFD3‐D14‐D53, thereby facilitating the efficient ...
Sheng Luo   +22 more
wiley   +1 more source

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