Results 51 to 60 of about 1,128,932 (296)

De Novo Discovery of Nonstandard Thioisoindole‐Bridged Bicyclic Peptides Targeting Traf2‐ and NCK‐Interacting Kinase

Angewandte Chemie, EarlyView.
An optimized strategy for the ribosomal synthesis of thioisoindole‐bridged bicyclic (TiB) peptides is incorporated into the RaPID platform, enabling high‐throughput discovery from topologically defined TiB libraries. Proof‐of‐concept selection against TNIK identifies nanomolar‐affinity ligands with inhibitory activity, while x‐ray crystallography ...
Yue Zhang, Alexander A. Vinogradov, Keisuke Hamada, Yin Sun, Toru Sengoku, Hiroaki Suga   +5 more
wiley   +2 more sources

Waste Wood for Designed Urban Amenities

Proceedings
Urban environments function as a set of interconnected ecological, social, and economic systems [...]
Ilze Stokmane, Una Ile
doaj   +1 more source

The paradox of youth empowerment: Exploring youth intervention programme in Ghana

Cogent Social Sciences, 2018
Empowerment is a necessary determinant of young people’s participation in national, regional and district or local level decision-making processes. For inclusiveness in any social intervention programme, the policy process should be all-embracing sharing
Isioma Ile, Evans Sakyi Boadu
doaj   +1 more source

Mediating Effect of Work Self-Efficacy on the Relationship Between Psychosocial Safety Climate and Workplace Safety Behaviors Among Bank Employees After Covid-19 Lockdown

Central European Management Journal, 2021
Purpose: Studies find that psychosocial safety climate is positively associated with workplace safety behaviors. However, the mechanism through which psychosocial safety climate exerts its effect needs further investigation.
Akanni Abimbola A., Ajila Chris O., Omisile Idowu O., Ndubueze Kelechi N.   +3 more
doaj   +1 more source

Covalently Linked Peptides and Membrane Potential Enable CyaA Segment Translocation

Advanced Science, EarlyView.
Using a newly developed Droplet Interface Bilayer‐Pipette assay, the authors show that two segments of the CyaA toxin cross membranes by distinct mechanisms. One segment translocates spontaneously, whereas the translocation of the other depends on membrane potential.
Gaia Scilironi, Nicolas Carvalho, Jacinthe Frangieh, Corentin Léger, Dorothée Raoux‐Barbot, J. Iñaki Guijarro, Daniel Ladant, Sophie Cribier, Nicolas Rodriguez, Alexandre Chenal   +9 more
wiley   +1 more source

Differential Water Networks Guide Selectivity Optimization of a Cell Active BPTF Inhibitor in Neuroblastoma

Angewandte Chemie, EarlyView.
BZ2 is a second‐generation Bromodomain PHD finger Transcription Factor (BPTF) inhibitor with improved selectivity over Class I and Class IV BRD off‐targets identified in our previously reported inhibitor, BZ1. Structural analyses reveal that water network engagement is key to this selectivity.
Kesavan Babu, Chun‐Ju Tsou, Sourav Das, Liying Fan, Anasuya Pal, Molly Sneddon, Timothy R. Stachowski, Priyanka Samanta, Stanley Nithianantham, Caroline Buchholz, Shi Zhang, Xiang Fu, Rahul S. Kathayat, Wenwei Lin, Yongtao Li, Lei Yang, Taosheng Chen, Marcus Fischer, Anang A. Shelat, William C. K. Pomerantz   +19 more
wiley   +2 more sources

The Mitogen‐Activated Protein Kinase GhNTF3 Modulates the Arbuscular Mycorrhizal Symbiosis‐Immunity Trade‐Off in Cotton by Regulating Salicylic Acid Biosynthesis

Advanced Science, EarlyView.
AM symbiosis induces GhWAK13 to promote fungal colonization. GhNTF3 negatively regulates symbiosis by promoting SA biosynthesis. GhWAK13 sequesters GhNTF3 at the membrane, limiting its nuclear translocation and relieving SA‐mediated suppression. Under Verticillium stress, GhNTF3 enters the nucleus and interacts with GhJAZ6 to activate SA signaling ...
Shuangjie Jia, Jingshang Wen, Jihang Li, Meina Feng, Yiming He, Ruojun Liu, Qian Liu, Junli Zhang, Kai Cheng, Xiangyu Zhang, Xiao Zhang   +10 more
wiley   +1 more source

Effects of Aqueous Shoot Extract of Tithonia diversifolia on the Growth of Seedlings of Monodora tenuifolia (Benth.), Dialium guineense (Willd.) and Hildegardia barteri (Mast.) Kosterm

Notulae Scientia Biologicae, 2011
The allelopathic effects of fresh shoot aqueous extract of Tithonia diversifolia (Hemsl.) A.Gray, an invasive species introduced into Africa from North and Central America, on the growth of seedlings of three woody species: Monodora tenuifolia, Dialium ...
SAMSON OLAJIDE OKE, Abisola Victoria AWOWOYIN, Shaid Remi OSENI, Emmanuel Lekan ADEDIWURA   +3 more
doaj   +3 more sources

Analysis of the Re-emergence and Occurrence of Cholera in Lagos State, Nigeria

Bulletin of Geography. Socio-Economic Series, 2017
This paper analysed the factors responsible for the re-emergence of cholera and predicted the future occurrence of Cholera in Lagos State, Nigeria using factor analysis, multiple linear regression analysis and a cellular automata model for the prediction.
Babatimehin Oyekanmi Isaac, Uyeh Joy Orevaoghene, Onukogu Angela Uloma   +2 more
doaj   +1 more source

Design of a Potent Combined Pseudopeptide Endothelin-A/Endothelin-B Receptor Antagonist, Ac-dBhg¹⁶-Leu-Asp-Ile-[NMe]Ile-Trp²¹ (PD 156252):  Examination of Its Pharmacokinetic and Spectral Properties

, 2016
The endothelins (ETs) are a family of bicyclic 21-amino acid peptides that are potent and prolonged vasoconstrictors. It has been shown that highly potent combined ETA/ETB receptor antagonists can be developed from the C-terminal hexapeptide of ET (His16-
Eric L. Reyner (3020322), Annette M. Doherty (3011343), Wayne L. Cody (2704033), Donnelle M. Walker (3020319), John X. He (3020325), Michael D. Reily (2107309), Stephen J. Haleen (3019623), Barbra H. Stewart (3020328)   +7 more
core   +1 more source