Imaging mass cytometry reveals tissue-specific cellular immune phenotypes in the mouse knee following ACL injury [PDF]
Osteoarthritis and Cartilage Open, 2023 Objective: To develop an imaging mass cytometry method for identifying complex cell phenotypes, inter-cellular interactions, and population changes in the synovium and infrapatellar fat pad (IFP) of the mouse knee following a non-invasive compression ...
Sanique M. South +8 more
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Imaging Mass Cytometry Analysis of immune Checkpoint Inhibitor-Related Pneumonitis: A Case Report [PDF]
Frontiers in Immunology, 2022 Immune checkpoint inhibitor-related pneumonitis (CIP) is a rare but well-recognized immune-related adverse event (irAE), causes 35% of irAE related deaths.
Yuan Cheng +8 more
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Multiplexed imaging mass cytometry reveals distinct tumor-immune microenvironments linked to immunotherapy responses in melanoma [PDF]
Communications Medicine, 2022 Xiao, Guo et al. use imaging mass cytometry to evaluate the spatial composition of the tumor microenvironment in melanoma. The authors identify features of the microenvironment associated with response to anti-PD-1 immunotherapy.
Xu Xiao +10 more
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Dual-modality imaging of immunofluorescence and imaging mass cytometry for whole-slide imaging and accurate segmentation [PDF]
Cell Reports: Methods, 2023 Summary: Imaging mass cytometry (IMC) is a powerful technique capable of detecting over 30 markers on a single slide. It has been increasingly used for single-cell-based spatial phenotyping in a wide range of samples.
Eun Na Kim +10 more
doaj +2 more sources
An imaging mass cytometry immunophenotyping panel for non-human primate tissues [PDF]
Frontiers in Immunology, 2022 It has recently become clear that spatial organization contributes to cellular function and that expanding our knowledge on cellular organization is essential to further our understanding of processes in health and disease. Imaging mass cytometry enables
Paula Niewold +4 more
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Application of High-Throughput Imaging Mass Cytometry Hyperion in Cancer Research [PDF]
Frontiers in Immunology, 2022 Imaging mass cytometry (IMC) enables the in situ analysis of in-depth-phenotyped cells in their native microenvironment within the preserved architecture of a single tissue section.
Marion Le Rochais +5 more
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IMC-Denoise: a content aware denoising pipeline to enhance Imaging Mass Cytometry [PDF]
Nature Communications, 2023 Multiplexed imaging technologies can reveal the complex cellular and molecular profiles of tissue. Here, the authors develop and implement a denoising pipeline to significantly enhance imaging mass cytometry quality and improve single-cell analyses.
Peng Lu +10 more
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Multidimensional profiling of drug‐treated cells by Imaging Mass Cytometry [PDF]
FEBS Open Bio, 2019 In pharmaceutical research, high‐content screening is an integral part of lead candidate development. Measuring drug response in vitro by examining over 40 parameters, including biomarkers, signaling molecules, cell morphological changes, proliferation ...
Alexandre Bouzekri +2 more
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Imaging mass cytometry for high-dimensional tissue profiling in the eye [PDF]
BMC Ophthalmology, 2021 Background Imaging mass cytometry (IMC) combines the principles of flow cytometry and mass spectrometry (MS) with laser scanning spatial resolution and offers unique advantages for the analysis of tissue samples in unprecedented detail.
Anja Schlecht +11 more
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Dice-XMBD: Deep Learning-Based Cell Segmentation for Imaging Mass Cytometry [PDF]
Frontiers in Genetics, 2021 Highly multiplexed imaging technology is a powerful tool to facilitate understanding the composition and interactions of cells in tumor microenvironments at subcellular resolution, which is crucial for both basic research and clinical applications ...
Xu Xiao +11 more
doaj +2 more sources