Results 11 to 20 of about 190,121 (278)

Imaging mass cytometry dataset of small-cell lung cancer tumors and tumor microenvironments [PDF]

BMC Research Notes
Objectives Small cell lung cancer (SCLC) accounts for approximately 15% of lung tumors and is marked by aggressive growth and early metastatic spread. In this study, we used two SCLC mouse models with differing tumor mutation burdens (TMB).
France Rose, Olta Ibruli, Luca Lichius, Martha Kiljan, Gokcen Gozum, Manoela Iannicelli Caiaffa, Jiali Cai, Li-na Niu, Jan M. Herter, Holger Grüll, Reinhard Büttner, Filippo Beleggia, Graziella Bosco, Julie George, Grit S. Herter-Sprie, Hans Christian Reinhardt, Katarzyna Bozek   +16 more
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From surfing to diving into the tumor microenvironment through multiparametric imaging mass cytometry [PDF]

Frontiers in Immunology
The tumor microenvironment (TME) is a complex ecosystem where malignant and non-malignant cells cooperate and interact determining cancer progression. Cell abundance, phenotype and localization within the TME vary over tumor development and in response ...
Marco Erreni, Marco Erreni, Maria Rita Fumagalli, Matteo Marozzi, Roberto Leone, Raffaella Parente, Raffaella D’Anna, Andrea Doni   +7 more
doaj   +2 more sources

Imaging mass cytometry reveals generalised deficiency in OXPHOS complexes in Parkinson’s disease [PDF]

npj Parkinson's Disease, 2021
Here we report the application of a mass spectrometry-based technology, imaging mass cytometry, to perform in-depth proteomic profiling of mitochondrial complexes in single neurons, using metal-conjugated antibodies to label post-mortem human midbrain ...
Chun Chen, David McDonald, Alasdair Blain, Ashwin Sachdeva, Laura Bone, Anna L. M. Smith, Charlotte Warren, Sarah J. Pickett, Gavin Hudson, Andrew Filby, Amy E. Vincent, Doug M. Turnbull, Amy K. Reeve   +12 more
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YOUPI: Your powerful and intelligent tool for segmenting cells from imaging mass cytometry data [PDF]

Frontiers in Immunology, 2023
The recent emergence of imaging mass cytometry technology has led to the generation of an increasing amount of high-dimensional data and, with it, the need for suitable performant bioinformatics tools dedicated to specific multiparametric studies.
Yvonne Scuiller, Patrice Hemon, Marion Le Rochais, Jacques-Olivier Pers, Jacques-Olivier Pers, Christophe Jamin, Christophe Jamin, Nathan Foulquier   +7 more
doaj   +2 more sources

Using Imaging Mass Cytometry to Define Cell Identities and Interactions in Human Tissues [PDF]

Frontiers in Physiology, 2021
In the evolving landscape of highly multiplexed imaging techniques that can be applied to study complex cellular microenvironments, this review characterizes the use of imaging mass cytometry (IMC) to study the human kidney.
Vijayakumar R. Kakade, Marlene Weiss, Lloyd G. Cantley   +2 more
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Adaptation of Imaging Mass Cytometry to Explore the Single Cell Alloimmune Landscape of Liver Transplant Rejection [PDF]

Frontiers in Immunology, 2022
Rejection continues to be an important cause of graft loss in solid organ transplantation, but deep exploration of intragraft alloimmunity has been limited by the scarcity of clinical biopsy specimens.
Nolan Ung, Cameron Goldbeck, Cameron Goldbeck, Cassandra Man, Cassandra Man, Julianne Hoeflich, Julianne Hoeflich, Ren Sun, Arianna Barbetta, Arianna Barbetta, Naim Matasci, Jonathan Katz, Jerry S. H. Lee, Jerry S. H. Lee, Jerry S. H. Lee, Shefali Chopra, Shefali Chopra, Shahab Asgharzadeh, Shahab Asgharzadeh, Mika Warren, Mika Warren, Linda Sher, Linda Sher, Rohit Kohli, Rohit Kohli, Omid Akbari, Omid Akbari, Yuri Genyk, Yuri Genyk, Juliet Emamaullee, Juliet Emamaullee, Juliet Emamaullee   +31 more
doaj   +2 more sources

Coupling imaging mass cytometry with Alcian blue histochemical staining for a single-slide approach [PDF]

Frontiers in Immunology
Imaging mass cytometry (IMC) is a metal mass spectrometry-based method allowing highly multiplex immunophenotyping of cells within tissue samples. However, some limitations of IMC are its 1-µm resolution and its time and costs of analysis limiting ...
Patrice Hemon, Danivanh Ben-Guigui, Margaux Geier, Margaux Geier, Marine Castillon, Marine Castillon, Corentin Paranthoen, Corentin Paranthoen, Jacques-Olivier Pers, Marion Le Rochais, Arnaud Uguen, Arnaud Uguen   +11 more
doaj   +2 more sources

Pan-cancer convergence of tumour–immune microenvironment motifs revealed by CyTOF and imaging mass cytometry [PDF]

Frontiers in Immunology
Mass cytometry (CyTOF) and Imaging Mass Cytometry (IMC) provide single-cell resolution for over 50 protein markers, enabling unprecedented exploration of tumour and immune heterogeneity.
Alexandre Vallée, Alexandre Vallée, Alexandre Drezet, Maxence Arutkin   +3 more
doaj   +2 more sources

Imaging mass cytometry reveals the prominent role of myeloid cells at the maternal-fetal interface [PDF]

iScience, 2022
Summary: Although the immunological complexity of the maternal-fetal interface is well appreciated, the actual interaction of maternal immune cells and fetal trophoblasts is insufficiently understood. To comprehend the composition and spatial orientation
Juliette Krop, Anita van der Zwan, Marieke E. Ijsselsteijn, Hanneke Kapsenberg, Sietse J. Luk, Sanne H. Hendriks, Carin van der Keur, Lotte J. Verleng, Antonis Somarakis, Lotte van der Meeren, Geert Haasnoot, Manon Bos, Noel F.C.C. de Miranda, Susana M. Chuva de Sousa Lopes, Marie-Louise P. van der Hoorn, Frits Koning, Frans H.J. Claas, Sebastiaan Heidt, Michael Eikmans   +18 more
doaj   +2 more sources

DNA-barcoded signal amplification for imaging mass cytometry enables sensitive and highly multiplexed tissue imaging. [PDF]

Nat Methods, 2023
Hosogane T, Casanova R, Bodenmiller B.
europepmc   +3 more sources