Results 61 to 70 of about 190,121 (278)

Somatostatin subtype-2 receptor-targeted metal-based anticancer complexes [PDF]

, 2012
Conjugates of a dicarba analogue of octreotide, a potent somatostatin agonist whose receptors are overexpressed on tumor cells, with [PtCl 2(dap)] (dap = 1-(carboxylic acid)-1,2-diaminoethane) (3), [(η 6-bip)Os(4-CO 2-pico)Cl] (bip = biphenyl, pico ...
Alejandro González-Cantó, Algueró B., Anna Massaguer, Barragán F., Barragán F., Bauer W., Carlos González, Cascini G. L., Casini A., Chaplin A. B., Charvat T. T., de Jong M., Deshmukh M. V., Dirscherl G., Dolors Carrion-Salip, D’Addona D., Fischer R., Flavia Barragán, Gariepy J., Gasser G., Gianferrara T., Gossens C., Gross A., Hodson E., Hornick C. A., Hsieh H.-P., Huang C. M., Irene Gómez-Pinto, Jakupec M. A., Jakupec M. A., Janecka A., Jennerwein M., Koradi R., Kostrhunova H., Kostrhunova H., Levina A., Liu H.-K., Marchán V., Marchán V., Melacini G., Metzler-Nolte N., Mezo G., Moradell S., Moreno V., Morris R. E., Mukhopadhyay S., Novakova O., Okarvi S. M., Peacock A. F. A., Peacock A. F. A., Peacock A. F. A., Peindy N’Dongo H. W., Peter J. Sadler, Pizarro A. M., Puckett C. A., Rademaker-Lakhai J. M., Rafael de Llorens, Reubi J. C., Reubi J. C., Schaer J. C., Singh S. K., Splith K., Sun L.-C., Süss-Fink G., van Rijt S. H., van Rijt S. H., van Rijt S. H., van Rijt S. H., Vicente Marchán, Virtudes Moreno, Wang F., Wang F., Watson J. C., Wheate N. J., Wynants C., Wynants C., Zaccaro L., Zhang J., Zhang Y.   +78 more
core   +5 more sources

Establishment and optimization of the two‐step induction system for generating primordial germ cell‐like cells from chicken embryonic stem cells

FEBS Open Bio, EarlyView.
This study optimizes a two‐step induction system to generate PGCLCs from chicken ESCs. The induced cells express germline markers and migrate to gonads in ovo, offering a novel approach for avian genetic resource conservation. Primordial germ cells (PGCs) are the progenitor cells of sperm and eggs.
Zeyu Li, XianShuai Xu, GuangZheng Liu, XiaoQian Lv, JiuZhou Song, HongYan Sun, YingJie Niu, QiSheng Zuo, Wei Han, BiChun Li, Kai Jin   +10 more
wiley   +1 more source

Single-cell mass cytometry in immunological skin diseases

Frontiers in Immunology
Immune-related skin diseases represent a collective of dermatological disorders intricately linked to dysfunctional immune system processes. These conditions are primarily characterized by an immoderate activation of the immune system or deviant immune ...
Mingming Zhao, Mingming Zhao, Mingming Zhao, Mingming Zhao, Yuqi Cheng, Yuqi Cheng, Yuqi Cheng, Yuqi Cheng, Jinping Gao, Jinping Gao, Jinping Gao, Jinping Gao, Fusheng Zhou, Fusheng Zhou, Fusheng Zhou, Fusheng Zhou   +15 more
doaj   +1 more source

Delivery of mixed-lineage kinase domain-like protein by vapor nanobubble photoporation induces necroptotic-like cell death in tumor cells [PDF]

, 2019
Modern molecular medicine demands techniques to efficiently deliver molecules directly into mammalian cells. As proteins are the final mediators of most cellular pathways, efficient intracellular protein delivery techniques are highly desired.
Braeckmans, Kevin, Brans, Toon, Declercq, Wim, Fraire, Juan, Raemdonck, Koen, Raes, Laurens, Roelandt, Ria, Saelens, Xavier, Stremersch, Stephan, Van Hoecke, Lien, Vandenabeele, Peter   +10 more
core   +2 more sources

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

Ampk regulates IgD expression but not energy stress with B cell activation. [PDF]

, 2019
Ampk is an energy gatekeeper that responds to decreases in ATP by inhibiting energy-consuming anabolic processes and promoting energy-generating catabolic processes.
Ahsan, Fasih M, Braas, Daniel, Graeber, Thomas G, Hong, Jason S, Kim, Diane NH, Minasyan, Aspram, Teitell, Michael A, Ten Hoeve, Johanna, Waters, Lynnea R, Zangle, Thomas A   +9 more
core   +1 more source

The Immobilization of Hyaluronic Acid in 3D Hydrogel Scaffolds Modulates Macrophage Polarization

Advanced Biology, EarlyView.
This study explores the use of collagen‐hyaluronic acid (HA) hydrogels for the 3D culture of macrophages, providing a useful tool for modelling macrophage behavior in tissues and diseases. It highlights how hydrogel composition, mechanical properties, and preparation methods influence macrophage behavior, revealing for the first time that HA's ...
Tiah CL Oates, Jasmin Boyd, Louise Dolan, C de Kergariou, Jingwen Zhu, Ash Toye, Adam W Perriman, Asme Boussahel   +7 more
wiley   +1 more source

Multiplex Stimulated Raman Scattering Imaging Cytometry Reveals Lipid-Rich Protrusions in Cancer Cells under Stress Condition

iScience, 2020
Summary: In situ measurement of cellular metabolites is still a challenge in biology. Conventional methods, such as mass spectrometry or fluorescence microscopy, would either destroy the sample or introduce strong perturbations to target molecules. Here,
Kai-Chih Huang, Junjie Li, Chi Zhang, Yuying Tan, Ji-Xin Cheng   +4 more
doaj   +1 more source

Radiosynthesis, in vitro and preliminary in vivo evaluation of the novel glutamine derived PET tracers [18F]fluorophenylglutamine and [18F]fluorobiphenylglutamine

, 2020
INTRODUCTION: Glucose has been deemed the driving force of tumor growth for decades. However, research has shown that several tumors metabolically shift towards glutaminolysis.
Baguet, Tristan, Beyzavi, M. Hassan, De Lombaerde, Stef, De Vos, Filip, Descamps, Benedicte, Donche, Sam, Goethals, Ingeborg, Hu, Jiyun, Lambe, Patricia, Pauwelyn, Glenn, Piron, Sarah, Vanhove, Christian, Verhoeven, Jeroen   +12 more
core   +1 more source

194P Achieving reproducible maturation staging of tertiary lymphoid structures: From imaging mass cytometry data to pathology applications [PDF]

, 2023
Marion Le Rochais, Soizic Garaud, Patrice Hémon, Arnaud Uguen   +3 more
openalex   +1 more source