Results 181 to 190 of about 22,275 (301)

A focus on lucigenin as a potent photoredox catalyst. [PDF]

Chem Sci
Aßenmacher D, Hein R.
europepmc   +1 more source

Inhibition of MEKK3 Prevents Cerebral Cavernous Malformation Progression Via Restoring Endothelial Integrity and Restricting Microglial Activation

Advanced Science, EarlyView.
In this study, we demonstrate that aberrant MEKK3 signaling in endothelial cells and microglia drives the progression of cerebral cavernous malformations (CCMs). Furthermore, we identify DPDH as a potent small‐molecule MEKK3 inhibitor with substantial therapeutic potential for CCM treatment.
Weiwei Zheng, Suyun Yu, Liwenyu Chen, Jing Ma, Peiliang Shen, Chang Yu, Xiaoqing Xin, Qiuhong Shen, Jing Chen, Song Ke, Hao Liu, Xiaobing Jiang, Ruogu Qi, Juming Yan, Jia Li, Jaesung P. Choi, Yin Lu, Yang Zhao   +17 more
wiley   +1 more source

Post-transplant BRAF/MEK inhibitor maintenance sustains complete remission in BRAF V600E-mutant histiocytic sarcoma. [PDF]

Ann Hematol
Karim I, Arnold T, Bräuninger A, Dohse M, Schell F, Samra MA, Tarawneh T, Burchert A, Gattenlöhner S, Sohlbach K.   +9 more
europepmc   +1 more source

An Engineered Supramolecular Pathway for Enhanced Electrochemiluminescence

Advanced Science, EarlyView.
A supramolecular electrochemiluminescent (ECL) system is presented in which cucurbit[7]uril (CB7) is covalently linked to [Ru(bpy)3]2+, forming a recognition‐responsive emitter. Host‒guest preorganization of tri‐n‐propylamine enables intramolecular ECL, boosting intensity by 162% compared to the standard system.
Maria Vittoria Balli, Madhurima Jana, Chiara Capolungo, Patrick Gruhs, Pierre Picchetti, Giovanni Valenti, Frank Biedermann, Luca Prodi   +7 more
wiley   +1 more source

Isotope-edited ESEEM: A new method for probing copper binding sites in neurodegenerative proteins. [PDF]

J Biol Chem
Millhauser GL, Singewald K, Smart A, Pavlovici FA.   +3 more
europepmc   +1 more source

Studies on Imidazol Derivatives

Bulletin of the Agricultural Chemical Society of Japan, 1928
YABUTA, TEIJIRO, KAMBE, KATSUJI
openaire   +1 more source

Sub‐Second Ratiometric Fluorescence Imaging of Histamine Dynamics in Living Cells via a Supramolecular Probe

Advanced Science, EarlyView.
A tailored tripartite supramolecular ratiometric probe, engineered by modulating the fluorogenic guest's cationic locus, enables ultrafast histamine monitoring in living cells. Utilizing a competitive displacement mechanism, this system achieves a sub‐second response time with high selectivity.
Chenming Chan, Yujie Han, Yu‐Fei Song, Chunlei Jiang, Qi‐Wei Zhang   +4 more
wiley   +1 more source

Magnetic catalyst marvels: a sustainable approach to highly substituted imidazole synthesis. [PDF]

Nanoscale Adv
Kazemi M, Javahershenas R, Makasana J, Ballal S, Kadheem M, Singh A, Chennakesavulu K, Joshi KK.   +7 more
europepmc   +1 more source

A Fluorogenic Cysteine‐Tetrapeptide Tagging Strategy for Nonperturbative Protein Labeling and Protein–Ligand Interaction Tracking

Advanced Science, EarlyView.
A compact Phe‐Cys‐Pro‐Phe (FCPF) tag and an environment‐sensitive SBD‐Cl‐derived probe form a sequence‐selective fluorogenic pair for wash‐free live‐cell protein imaging. This minimally perturbing chemistry allows flexible insertion at termini or loops, produces strong fluorescence upon local microenvironment confinement, supports FRET‐assisted ...
Xiao Wang, Xingcan Pan, Yongling Ying, Ziqian Bai, Jingming Zhang, Zhuang Shao, Jialiang Qian, Hongwei Li, Ning Zhang, Fan Yang, Yuan Liu, Xing Yang   +11 more
wiley   +1 more source

Discovery and Evaluation of Spirofluorenes Based on Imidazolidinedione as Insecticidal Agent Leads. [PDF]

Chem Biodivers
Al-Ghamdi SN, Asiri FM, Mashnoy IY, Alageel AA, Alotaibi OJ, Alqahtani NH, Gad MA, Abdelhamid AA.   +7 more
europepmc   +1 more source