Results 191 to 200 of about 30,850 (304)

A Case of Immunotherapy Response to BRAF^V600E-Mutant Lung Adenocarcinoma With Initial Resistance to Dabrafenib and Trametinib Combination Therapy. [PDF]

Cancer Rep (Hoboken)
Okayama Y, Tokito T, Shiraishi S, Takaki R, Tsuneyoshi S, Yamada H, Nishiyama M, Sueyasu Y, Hoshino T.   +8 more
europepmc   +1 more source

Accelerating Biosensor Discovery: A Computationally‐Driven Pipeline for Microplastics Monitoring

Advanced Intelligent Discovery, EarlyView.
A computationally guided pipeline unites molecular simulation, synthetic biology, electrochemical engineering, and machine learning to accelerate biosensor discovery. A Bacillus anthracis carbohydrate‐binding module is used to develop a high‐performance micro‐ and nanoplastics sensor with greatly reduced error and variability.
Gabriel X. Pereira, Marcos de C. Leite, Pedro H. M. Zanineli, Juliana N. Y. Costa, Débora M. Cunha, Sophia P. Serra, Pedro H. Sophia, Flávio M. Shimizu, Yasmin W. Moura, Célio C. Oliveira, Gabriel R. Schleder, Gabriela F. Persinoti, Leandro Merces, Renato S. Lima   +13 more
wiley   +1 more source

Synthesis of Cyclopropene‐Modified Fatty Acids Allows Single‐Cell Quantification of Uptake by Immune Cells

Angewandte Chemie, EarlyView.
Cyclopropene fatty acids have been made that allow the study of fatty acid uptake in complex mixtures of immune cells with single cell resolution and combined with metabolic and proteomic analysis so that for the first time nutrient uptake can be correlated to the phenotype of single immune cell.
Luuk Reinalda, Graham A. Heieis, Laura Bogue Edgerton, Kristine Bertheussen, Diana Torres‐García, Marouane el Boujadayni, Kas Steuten, Jeroen M. Punt, Wouter P. F. Driever, Connor Corrigan, Xinyuan Wang, Bart Everts, David Finlay, Mario van der Stelt, Sander I. van Kasteren   +14 more
wiley   +2 more sources

Synthesis of 1-Fluoroalkyl-5-Substituted-1,2,3-Triazoles from Carbonyl-Stabilized Phosphonium Ylides. [PDF]

J Org Chem
Tichý D, Černý T, Filgas J, Voltrová S, Klepetářová B, Beier P.   +5 more
europepmc   +1 more source

Comparison of Receptor‐Mediated Endocytosis and Its Application to Enhance DNA Transfection by TFAMoplex

Advanced NanoBiomed Research, EarlyView.
We developed an assay to distinguish cellular binding from internalization. Compatible with microscopy and high‐throughput screening, the method identifies ligand‐mediated uptake. Applying top candidates to a protein‐based DNA carrier enhanced transfection efficiency, providing a rational strategy to improve non‐viral gene delivery systems.
David Scherer, Steffen Honrath, Jonas Kurmann, Alexander Klipp, Finn Brigger, Jean‐Christophe Leroux   +5 more
wiley   +1 more source

Wet Transfer of In Situ Grown Azo‐Containing Two‐Dimensional Conjugated Covalent Organic Framework Films for Photoswitchable Electronic Devices

Angewandte Chemie, EarlyView.
Wet transfer of an atomically flat azo‐functionalized 2D covalent organic framework film onto monolayer MoS2 enables clean van der Waals heterostructure devices with reversible photoswitching and multilevel nonvolatile memory. ABSTRACT Two‐dimensional π‐conjugated covalent organic frameworks (2D π‐COFs) combine in‐plane π‐delocalization with periodic ...
Kexin Wang, Bin Han, Fan Qiu, Yeonsu Jeong, Yusheng Chen, Yubin Fu, Christos Gatsios, Marco Vittorio Nardi, Melanie Timpel, Yang Hou, Shun‐Qi Xu, Paolo Samorì   +11 more
wiley   +2 more sources

Electrodeficient Diborane (4) Converted into an Extraordinary Proton Sponge. [PDF]

J Phys Chem A
Yáñez M, Montero-Campillo MM, Mó O, Alkorta I.   +3 more
europepmc   +1 more source

DERIVADOS METÁLICOS DE IMIDAZOLES CON Cu(II), Zn(II) Y Ag(I) Y SU POTENCIAL USO COMO AGENTES ANTIMICÓTICOS CONTRA CANDIDA ALBICANS [PDF]

, 2014
Estrada Garcia, Fernando, Morales Juarez, Telesforo Jesus   +1 more
core  

A Cholesterol Analogue for Cell‐Surface Enzyme Display

Angewandte Chemie, EarlyView.
We report a non‐genetic strategy for bacterial cell surface enzyme immobilisation using cholesterol‐based artificial lipids containing Ni2+‐NTA binding groups that can integrate into biological membranes. The engineered cells can capture His‐tagged enzymes directly from cell lysates while preserving intracellular and surface activity, allowing for ...
Vasco F. Batista, Nele Van Wyngaerden, Changzhu Wu, Frank Glorius   +3 more
wiley   +2 more sources

Indole-Imidazole Hybrids as Emerging Therapeutic Scaffolds: Synthetic Advances and Biomedical Applications. [PDF]

Molecules
Bawazir WA, Ain Q.
europepmc   +1 more source