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Imidazole anticonvulsants: structure-activity relationships of [(biphenylyloxy)alkyl]imidazoles
Journal of Medicinal Chemistry, 1987The [(biphenylyloxy)alkyl]imidazoles were found to be potent anticonvulsants. The most potent compound of the series, 1-[2- ([1,1'-biphenyl]-2-yloxy)ethyl]-1H-imidazole (4), had an ED50 of 15.5 mg/kg against maximal-electroshock-induced seizures in mice after oral administration; the horizontal screen ED50 was 320 mg/kg, revealing that the compound has
D W, Robertson +3 more
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Synthesis of oxathiolane imidazole nucleosides
Il Farmaco, 2002AbstractFor Abstract see ChemInform Abstract in Full Text.
Ayse, Kocabalkanli, Raymond F, Schinazi
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The Journal of Organic Chemistry, 1991
We wished to establish definitively the extent to which imidazol-5-yllithium and imidazol-4-yllithium species could be generated and quenched with electrophilic reagents in the presence of an unsubstituted C2 carbon atom ...
Michael P. Groziak, Lulin Wei
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We wished to establish definitively the extent to which imidazol-5-yllithium and imidazol-4-yllithium species could be generated and quenched with electrophilic reagents in the presence of an unsubstituted C2 carbon atom ...
Michael P. Groziak, Lulin Wei
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On the photochemical phosphorylation of imidazole
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1972Abstract It has not proved possible to repeat the reported anaerobic photophosphorylation of imidazole to produce imidazole 1-phosphate. The involvement of an analogous reaction in mitochondrial oxidative phosphorylation is therefore further in doubt.
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New complexes of copper cinnamates and imidazole or substituted imidazole
Thermochimica Acta, 1993Abstract We have prepared five new organo-metallic complexes of imidazoles and a dicarboxylate, copper cinnamate, which may be considered as extremely simple models of the active centres in most biocatalysts. The thermal behaviour of the complexes was studied. Using ESR and diffuse reflectance spectra, monomeric or dimeric species were detected.
A. Busnot +3 more
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