Results 1 to 10 of about 84,383 (190)

Imipenem in the Rat Brain: A Multidimensional Study on Hippocampal Behavior, GABAergic System, Astrocyte Response, and Neurogenesis [PDF]

Antibiotics
Background: After imipenem was introduced in clinical practice, neurologic adverse effects led to recommendations against its use in patients with neurologic conditions. However, these conclusions were drawn without considering pharmacokinetic variations
Leonardo Araújo-Andrade, Bárbara Caetano-Mota, Inês Silva, Ana Rogeiro, Pedro Nogueira, Ana Silva, Pedro A. Pereira, Maria Dulce Madeira, Armando Cardoso   +8 more
doaj   +2 more sources

Population pharmacokinetics of imipenem in different populations for individualized dosing: a systematic review [PDF]

Frontiers in Pharmacology
BackgroundImipenem is a broad-spectrum carbapenem antibiotic for severe infections with significant pharmacokinetic (PK) variability. This review systematically synthesized published population pharmacokinetic (popPK) studies to identify key covariates ...
Ping Zhang, Yuhua Zhao, Jianping Zhu, Yi Yang, Gang Liang, Xia Wang, Zhenwei Yu, Zhenwei Yu   +7 more
doaj   +2 more sources

Carbapenem resistance associated with coliuria among outpatient and hospitalised urology patients

New Microbes and New Infections, 2022
The World Health Organization in 2017 listed carbapenem resistant Enterobacteriaceae (CRE) with critical priority for research. A research to assess carbapenem resistant Escherichia coli (CREc) in coliuria among the outpatients and inpatients of a ...
A.A. Adegoke, W.E. Ikott, A.I. Okoh
doaj   +1 more source

Effect of Oxygen and Water on the Stability of Imipenem and Cilastatin Sodium for Injection

Pharmaceutical Fronts, 2022
The study aimed to investigate the factors affecting the stability of imipenem and cilastatin sodium for injection (IMI/CIL) to improve the quality and stability in IMI/CIL preparation.
Meng Zhang, Chun-Feng Liu, Xiao-Yan Chen, Li-Na Yang, Chun-Mei Zhu, Jian-Hao Teng, Hao-Xiang Wu, Fu-Li Zhang   +7 more
doaj   +1 more source

Primary Bacteremia Caused by Rhizobium radiobacter in Neonate: A Rare Case Report [PDF]

Journal of Clinical and Diagnostic Research, 2015
Rhizobium radiobacter is a gram-negative tumourigenic plant pathogen that rarely causes infections in humans. Rhizobium radiobacter has a strong predilection to cause infection particularly in those patients who have long standing indwelling foreign ...
Shreekant Tiwari, Siba Shanker Beriha
doaj   +1 more source

Aerobacterial Vaginosis among Women Attending an Infertility Clinic at a Tertiary Care Hospital in Chennai, India and Susceptibility Pattern of Isolates

Journal of Pure and Applied Microbiology, 2021
Genital infections and subsequent vaginosis diagnosed through high vaginal swab in women is caused due to fungi or bacteria. The presented study focused on determining the types, numbers and antibacterial susceptibility pattern of aerobic bacteria ...
Abigail R. Sopia, Pushpa Innocent D. Joseph, M. Kalyani, B. Ananthi, Suresh Dhanaraj, Allen John Henry   +5 more
doaj   +1 more source

Bacterial membrane vesicles from Acinetobacter baumannii induced by ceftazidime are more virulent than those induced by imipenem

Virulence, 2020
Patients with Acinetobacter baumannii bacteremia treated with antipseudomonal cephalosporins showed higher 14-day mortality than patients treated with antipseudomonal carbapenems.
Chun-Hsiang Chiu, Yi-Tzu Lee, Yu-Chun Lin, Shu-Chen Kuo, Ya-Sung Yang, Yung-Chih Wang, Yu-Han Liu, Jung-Chung Lin, Feng-Yee Chang, Te-Li Chen   +9 more
doaj   +1 more source

Methodology Establishment and Application of VITEK Mass Spectrometry to Detect Carbapenemase-Producing Klebsiella pneumoniae

Frontiers in Cellular and Infection Microbiology, 2022
The ability of VITEK mass spectrometry (MS) in detection of bacterial resistance is currently under exploration and evaluation. In this study, we developed and validated a VITEK MS method to rapidly test carbapenemase-producing Klebsiella pneumoniae ...
Haoyun Lin, Zhen Hu, Jinsong Wu, Yuemei Lu, Jine Chen, Wenyuan Wu   +5 more
doaj   +1 more source

Imipenem/Relebactam Ex Vivo Clearance during Continuous Renal Replacement Therapy

Antibiotics, 2021
(1) Purpose of this study: determination of adsorption and transmembrane clearances (CLTM) of imipenem and relebactam in ex vivo continuous hemofiltration (CH) and continuous hemodialysis (CHD) models.
Soo Min Jang, Lenar Yessayan, Michael Dean, Gabrielle Costello, Ravi Katwaru, Bruce A. Mueller   +5 more
doaj   +1 more source

Empiric Antibiotic Therapy in the Treatment of Community-acquired Pneumonia in a General Hospital in Saudi Arabia [PDF]

, 2019
Background: Guideline-based empiric antimicrobial therapy is recommended for the treatment of community-acquired pneumonia (CAP). In this study, we evaluate the pattern of empiric antibiotics of CAP patients.
Al-Tawfiq, Jaffar A., Hinedi, Kareem, Momattin, Hisham   +2 more
core   +1 more source