Population pharmacokinetics and dosing optimization of imipenem in Chinese elderly patients
Frontiers in PharmacologyObjectivesTo assess the pharmacokinetics and pharmacodynamics of imipenem in a retrospective cohort of hospitalized Chinese older patients.MethodsA population pharmacokinetic (PPK) model was constructed utilizing a nonlinear mixed-effects modeling ...
Jing Wang +5 more
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Microbiology Spectrum, 2022 Extensively drug-resistant Pseudomonas aeruginosa (XDRPA) infection is a significant public health threat due to a lack of effective therapeutic options. New β-lactam-β-lactamase inhibitor combinations, including ceftazidime-avibactam (CZA), have shown a
Yulin Zhang +10 more
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The microbiota of the bilio-pancreatic system: A cohort, STROBE-compliant study [PDF]
, 2019 Background: The gut microbiota play an essential role in protecting the host against pathogenic microorganisms by modulating immunity and regulating metabolic processes.
Agrusa A. +8 more
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Serratia Marcescens- A Rare Opportunistic Nosocomial Pathogen and Measures to Limit its Spread in Hospitalized Patients [PDF]
Journal of Clinical and Diagnostic Research, 2013 Background: In November 2011, 6 patients who were in the ICU of the Sri Guru Ram Dass Institute of Medical Sciences and Research acquired an infection which was caused by Serratia marcescens.
Ashish Khanna +2 more
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In Vitro Antibacterial Activity of Imipenem/Relebactam against Clinical Isolates in Japan
Microbiology Spectrum, 2022 Relebactam is a novel β-lactamase inhibitor of Ambler class A and C β-lactamases that has been developed in combination with imipenem/cilastatin for the treatment of carbapenem-resistant bacterial infections.
Dai Kurihara +4 more
doaj +1 more source
Synergistic Alleviation of Inflammatory Cytokine Storms in Sepsis Rats by Low‐Intensity Pulsed Ultrasound and Imipenem [PDF]
Mediators of Inflammation, Volume 2026, Issue 1, 2026.Aims This study aimed to investigate the effects of low intensity pulsed ultrasound (LIPUS) combined with imipenem (IMI) on inflammatory responses and organ protection in septic rats. Results The study involved 230 Sprague–Dawley (SD) rats, with 80 used for survival analysis and 150 for sampling over 72 h.
Wentao Tang +12 more
openalex +2 more sources
Molecules, 2022 β-Lactam antibiotics are most commonly used in the critically ill, but their effective dosing is challenging and may result in sub-therapeutic concentrations that can lead to therapy failure and even promote antimicrobial resistance.
Robert Włodarski +2 more
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Presence of New Delhi metallo-β-lactamase gene (NDM-1) in a clinical isolate of Acinetobacter junii in Argentina [PDF]
, 2016 Here we report the presence of a clinically significant A. junii blaNDM-1 positive in a 38-year-old woman who was admitted to the emergency department with a fever and leg ulcers with signs of infection.
Almuzara, Marisa +8 more
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Drug Utilization Evaluation of Imipenem and Assessing the Role of Pharmacist Interventions
Journal of Mazandaran University of Medical Sciences, 2020 Background and purpose: This study aimed at evaluating utilization of imipenem and assessing the role of pharmacist in rational use of antibiotics. Materials and methods: A retrospective/prospective observational study was conducted in Ramsar Imam Sajjad
Neda Farzadi +3 more
doaj
Evaluation of the Carba NP Test for the Detection of Carbapenemase Activity in Bacteroides Species [PDF]
Polish Journal of Microbiology, 2018 We evaluated the usefulness of the Carba NP test for rapid detection of carbapenemase activity in Bacteroides spp. The minimum inhibitory concentration (MIC) for imipenem was determined with gradient test strips, and cfiA gene was investigated by ...
Isin Akyar +3 more
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