Results 51 to 60 of about 28,814 (216)

Depletion of p75NTR in Schwann Cells Driven by Inflammation Mediates Cutaneous Pain in Psoriasis

Advanced Science, EarlyView.
Psoriasis‐like inflammation induces proliferation and molecular remodeling of cutaneous Schwann cells, marked by reduced p75NTR and increased NGF expression. IL‐17A promotes this process, whereas Schwann cell‐specific p75NTR overexpression alleviates cutaneous pain in vivo.
Yibo Wang, Linlin Xu, Chenglong Pan, Ruonan Cao, Piao Zeng, Xinxing Lyu, Qingxia Hu, Zhenzhen Yan, Shuhong Huang, Ningning Dang   +9 more
wiley   +1 more source

Evaluating the Effects of Imiquimod on Paths of TLRs and Inflammatory Cytokines Signaling in Infected Macrophages with Leishmania major in Vitro and in Vivo

Iranian Journal of Parasitology
Background: Leishmania major is an obligate and intracellular pathogen and the macrophages are the cell hosts for L. major. Imiquimod stimulates macrophages to secrete different cytokines via the expression of TLRs.
Parisa Ebrahimisadr, Fatemeh Ghaffarifar, Javad Jabari, John Horton, Zohreh Sharifi, Abdolhossein Dalimi, Mohammad Saaid Dayer   +6 more
doaj   +1 more source

Vulvar vitiligo-like depigmentation and multiple halos of hypomelanosis at the trunk following treatment with imiquimod 5% cream for vulvar condylomata: casual or related events? [PDF]

Anais Brasileiros de Dermatologia, 2014
A 25-year-old Caucasian female with multiple genital warts involving the vulvar area was treated with imiquimod 5% cream. During follow-up the patient developed areas of hypopigmentation at the site of application of imiquimod cream and areas of ...
Maíra Chiarelli Serra, Claudia Menicanti, Elisabetta Pennacchioli, Giulio Tosti   +3 more
doaj   +1 more source

Dysregulation of Amino Acid Transporters in a Rat Model of TLR7-Mediated Maternal Immune Activation

Pharmaceutics, 2023
Maternal immune activation (MIA) during pregnancy is linked to neurodevelopmental disorders in humans. Similarly, the TLR7 agonist imiquimod alters neurodevelopment in rodents.
Eliza R. McColl, Jeffrey T. Henderson, Micheline Piquette-Miller   +2 more
doaj   +1 more source

5-hydroxymethylcytosine is a key epigenetic regulator of keratinocyte stem cells during psoriasis pathogenesis [PDF]

, 2019
Epigenetic regulation is now known to play an important role in determining stem cell fate during normal tissue development and disease pathogenesis. In this study, we report loss of 5-hydroxymethylcytosine (5-hmC) mediated by ten-eleven translocation ...
Yuan, Christine Wan-Yin
core  

Population-level impact and herd effects following the introduction of human papillomavirus vaccination programmes: updated systematic review and meta-analysis [PDF]

, 2019
Background More than 10 years have elapsed since human papillomavirus (HPV) vaccination was implemented. We did a systematic review and meta-analysis of the population-level impact of vaccinating girls and women against human ...
\uc9lodie, B\ue9nard, A Kahn, Jessica, A Machalek, Dorothy, A Smith, Megan, Ali, Hammad, Baldo, Vincenzo, Boily, MarcMarie\uadClaude, Brassard, Paul, Brisson,, Callander, Denton, Checchi, Marta, Cocchio, Silvia, Dalianis, Tina, Dehlendorff, Christian, Donovan, Basil, F Chow, Eric P, G Pollock, Kevin, Gr\ufcn, Nathalie, Harrison, Christopher, Herweijer, Eva, J Woestenberg, Petra, Jes\ufas Purri\uf1os\uadHermida, Mar\ueda, K Fairley, Christopher, K Kjaer, Susanne, Kavanagh, Kimberley, L Brotherton, Julia M, L Deeks, Shelley, Liu, Bette, M Garland, Suzanne, M Imburgia, Teresa, M Johnson, Anne, M Wheeler, Cosette, M\ue9lanie, Drolet, Markowitz, Lauri, Mesher, David, Munk, Christian, Niccolai, Linda, Norma, P\ue9rez, Nyg\ue5rd, Mari, Ogilvie, Gina, Oliphant, Jeannie, S\uf6derlund\uadStrand, Anna, Sonnenberg, Pam, Sparen, P\ue4r, Steben, Marc, T Hansen, Bo, Tanton, Clare, V Kliewer, Erich, W Flagg, Elaine, W Gargano, Julia, Yu., Bo Nancy   +50 more
core   +2 more sources

18β‐Glycyrrhetinic Acid and a Nano‐Liposomal Formulation Alleviate Depression‐Like Behaviors via the Microglial mTOR‐Autophagy‐NLRP3 Axis

Advanced Science, EarlyView.
Using a novel zebrafish‐based inflammatory screening strategy, we screened and identified 18β‐glycyrrhetinic acid (18β‐GA) as a promising anti‐inflammatory candidate. We uncover a microglial mTOR–autophagy–NLRP3 axis that constitutes the mechanistic core of 18β‐GA–mediated neuroprotection.
Hua Gan, Haitao Yuan, Wenjun Zhu, Xiaokang Xie, Shen Zhou, Wenzhi Hao, Xiaowei Mo, Lian Yang, Xiaojuan Li, Junshan Liu, Lijuan Deng, Jiaxu Chen   +11 more
wiley   +1 more source

Imiquimod Reverses Chronic Toxoplasmosis-Associated Behavioral and Neurocognitive Anomalies in a Rat Model

Biomedicines
Toxoplasma gondii is the etiologic agent of toxoplasmosis, a highly prevalent parasitosis. Toxoplasma gondii (T. gondii) transits in the brain from acute (AT) to chronic toxoplasmosis (CT), under host immune control.
Shaymaa Itani, Maguy Hamie, Reem El Jammal, Wassim Abdine, Mark Doumit, Adib Charafeddine, Marwan El-Sabban, Cindy Patinote, Carine Masquefa, Pierre-Antoine Bonnet, Makram Obeid, Hiba El Hajj   +11 more
doaj   +1 more source

Evaluation of the Effect of Topical Artemisia dracunculus Administration on Serum Levels of Selected Interleukins and Spleen Index in Imiquimod-Induced Psoriasis in Male Mice Compared to Clobetasol Propionate (Dermovate (R)) Ointment

Iraqi Journal of Pharmaceutical Sciences, 2020
Psoriasis is a long-lasting autoimmune disease that is characterized by swollen skin patches. Normally, these skin patches are dark, swollen, itchy and scaly.
Thamer M. Mohammed, Shihab H. Mutlag, Bahaa A.Shihab   +2 more
doaj   +1 more source

Treatment of recurrent mucosal melanoma of the oral cavity with topical imiquimod and pembrolizumab achieves complete histopathologic remission

Journal for ImmunoTherapy of Cancer, 2021
Mucosal melanomas constitute a subtype of melanoma with less effective treatments than cutaneous melanomas. We present a case of oral mucosal melanoma that recurred despite multiple resections and adjuvant temozolomide.
Richard Carvajal, Shaheer Khan, Tejus Satish, Matt Levin, Angela J Yoon   +4 more
doaj   +1 more source