Results 211 to 220 of about 322,455 (262)

Immediate Release of Crystallographic Data: A Proposal

Science, 1998
For several years, Science policy has required that published X-ray crystallographic coordinates be deposited with a publically accessible database (e.g., Brookhaven Protein Data Bank). That policy recognized the high costs and risks of solving important structures to accord those who have made such investments successfully the time to reap their ...
A, Wlodawer, D, Davies, G, Petsko, M, Rossmann, A, Olson, J L, Sussman   +5 more
openaire   +2 more sources

Bioequivalence of immediate-release theophylline capsules

Biopharmaceutics & Drug Disposition, 1999
A three-way crossover study in 18 healthy male volunteers was conducted to evaluate the bioequivalence of three different 200 mg anhydrous theophylline immediate-release (IR) capsules. The products had not been rated as therapeutically equivalent by the US Food and Drug Administration (FDA) owing to a lack of bioequivalence data.
M C, Meyer, E J, Jarvi, A B, Straughn, F R, Pelsor, R L, Williams, V P, Shah   +5 more
openaire   +2 more sources

Oxybutynin Extended Release and Tolterodine Immediate Release

Clinical Drug Investigation, 2004
To evaluate the cost-effectiveness of a new extended-release (XL) formulation of oxybutynin relative to tolterodine immediate release (IR), currently the most prescribed treatment for overactive bladder in the UK.A state-transition model was developed to compare outcomes over 1 year.
D, Getsios, J J, Caro, K J, Ishak, W, El-Hadi, K, Payne, M, O'connel, D, Albrecht, W, Feng, D, Dubois   +8 more
openaire   +2 more sources

A case for immediate-release niacin

Heart & Lung, 2012
Niacin is currently a favored drug for increasing high-density lipoprotein, especially in patients with ischemic heart disease or at high risk of developing it. In addition, niacin further decreases low-density lipoprotein in statin-treated patients and has been shown to reduce morbidity and mortality.
openaire   +2 more sources

Tapentadol immediate-release for acute pain

Expert Review of Neurotherapeutics, 2010
Tapentadol is a novel opioid agent with a dual mode of analgesic action. The inhibition of norepinephrine combined with moderate opioid agonist activity results in fewer gastrointestinal adverse effects compared with equianalgesic doses of oxycodone.
openaire   +2 more sources

Clinical Evaluation of Modified Release and Immediate Release Tacrolimus Formulations

The AAPS Journal, 2017
The science of drug delivery has evolved considerably and has led to the development of multiple sustained release formulations. Each of these formulations can present particular challenges in terms of clinical evaluation and necessitate careful study to identify their optimal use in practice.
Simon, Tremblay, Rita R, Alloway
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Immediate and controlled-release pregabalin for the treatment of epilepsy

Expert Review of Neurotherapeutics, 2019
Introduction: Epilepsy is a common neurological disease requiring complex therapies, which are unable to achieve seizure control in 30% of patients. Poor adherence has been recognized as a possible determinant of drug-resistance. Prolonged-release formulations of antiepileptic drugs might help increase adherence and minimize side effects.Areas covered:
Alessandra Morano, Caterina Palleria, Rita Citraro, Valentina Nesci, Carmen De Caro, Anna Teresa Giallonardo, Giovambattista De Sarro, Emilio Russo, Carlo Di Bonaventura   +8 more
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Immediate postabortal insertion of a levonorgestrel-releasing IUD

Contraception, 1982
Experimental IUDs releasing only 10 μg levonorgestrel per day and established copper-releasing IUDs (Nova-T) were inserted in 60 women in connection with legal first-trimester abortion. Bleeding and spotting and other events were recorded during the first year. Restoration of the menstrual cycle was studied.
M, Heikkilä, P, Lähteenmäki, T, Luukkainen   +2 more
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Immediate-release versus controlled-release carbamazepine in the treatment of epilepsy

2008
Epilepsy is defined as the tendency to spontaneous, excessive neuronal discharge, manifesting as seizures. It is a common disorder with an incidence of 50 per 100,000 per year and a prevalence of 0.5% to 1% (Hauser 1993) in the developed world.Carbamazepine is a commonly used antiepileptic drug that is associated with a number of troublesome adverse ...
Graham, Powell, Matthew, Saunders, Anthony G, Marson   +2 more
openaire   +3 more sources

Closure of Interatrial Defects by Immediate-Release Patch

Pediatric Cardiology, 2012
The Immediate-Release Patch is the newest version of the Transcatheter Patch, which is a bioabsorbable device for the closure of cardiac defects. Closure of 12 atrial septal defects and 1 fenestration was attempted using this device. Of the 13 devices used, 12 were implanted successfully (including that for the fenestration), whereas 1 device moved ...
Aliakbar, Zeinaloo, Keyhan Sayadpour, Zanjani, Bahman, Rastkar, Alimohammad, Hajizeinali, Bahram, Sohrabi, Mahmoud, Samadi, Eleftherios B, Sideris   +6 more
openaire   +2 more sources