Results 31 to 40 of about 21,568 (259)

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

AnywhereXR: on-the-fly 3D environments as a basis for open source immersive digital twin applications

International Journal of Digital Earth
Visualization has long been fundamental to human communication and decision making. Today, we stand at the threshold of integrating veridical, high-fidelity visualizations into immersive digital environments, alongside digital twinning techniques.
Alexander Klippel, Bart Knuiman, Jiayan Zhao, Jan Oliver Wallgrün, Jascha Grübel   +4 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Towards future of work in immersive environments and its impact on the Quality of Working Life: a scoping review

i-com
In recent years, immersive environments and the technologies employed within them, such as Augmented Reality (AR), Virtual Reality (VR), and Mixed Reality (MR), have become increasingly significant, particularly in the domains of education, work, and ...
Paetow Thomas, Wichmann Johannes, Leyer Michael, Schmolke Marianne   +3 more
doaj   +1 more source

TPACK-XD: Expanding the TPACK Framework for Metaverse-Based Higher Education Learning Environments

Seminar.net
The integration of immersive metaverse-based environments into higher education challenges existing conceptualisations of teacher knowledge. While the Technological Pedagogical Content Knowledge (TPACK) framework has guided technology integration in ...
Cristina Obae
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Towards a Model of User Experience in Immersive Virtual Environments

Advances in Human-Computer Interaction, 2018
There are increasing new advances in virtual reality technologies as well as a rise in learning virtual environments for which several studies highlighted the pedagogical value, knowledge transfer, and learners’ engaged-behaviors. Moreover, the notion of
Katy Tcha-Tokey, Olivier Christmann, Emilie Loup-Escande, Guillaume Loup, Simon Richir   +4 more
doaj   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

The Influence of Immersive Environments on the Empathy Construct about Schizophrenia

Proceedings, 2019
This work explores the potential of the use of interactive and immersive technologies to create impactful experiences that generate emotions, contributing to the process of activation or somatic excitation that triggers links that strengthen cognitive ...
Paulo Veloso Gomes, António Marques, Javier Pereira, João Donga   +3 more
doaj   +1 more source