Results 1 to 10 of about 6,308 (185)

Clinical Characteristics and Management of Statin-Associated Anti-3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Immune-Mediated Necrotizing Myopathy. [PDF]

J Clin Med
Background: Immune-mediated necrotizing myopathy (IMNM) associated with anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) antibody is a rare but critical complication usually triggered by statin use. However, the comprehensive characterization
Yoon J, Kim SW, Kim SH, Song JJ, Park YB, Park HJ, Shin HY, Park SH, Rhee Y.   +8 more
europepmc   +3 more sources

Immune-Mediated Necrotizing Myopathy [PDF]

Current Rheumatology Reports, 2018
Immune-mediated necrotizing myopathy (IMNM) is a type of autoimmune myopathy characterized by relatively severe proximal weakness, myofiber necrosis with minimal inflammatory cell infiltrate on muscle biopsy, and infrequent extra-muscular involvement. Here, we will review the characteristics of patients with IMNM.Anti-signal recognition particle (SRP ...
Iago Pinal-Fernandez
exaly   +4 more sources

Profiling of Anti-Signal-Recognition Particle Antibodies and Clinical Characteristics in South Korean Patients With Immune-Mediated Necrotizing Myopathy. [PDF]

J Clin Neurol
Background and Purpose This study evaluated the diagnostic utility of an anti-signal-recognition particle 54 (anti-SRP54) antibody-based enzyme-linked immunosorbent assay (ELISA) as well as the clinical, serological, and pathological characteristics of ...
Kim SH, Choi Y, Oh EK, Nishino I, Suzuki S, Suh BC, Shin HY, Kim SW, Yoon BA, Oh SI, Kim YH, Kim H, Lim YM, Baek SH, Shin JY, Seok HY, Lee SA, Choi YC, Park HJ.   +18 more
europepmc   +4 more sources

Immune-mediated necrotizing myopathy: Report of two cases. [PDF]

World J Clin Cases, 2023
Immune-mediated necrotizing myopathy is a rare autoimmune myopathy characterized by muscle weakness and elevated serum creatine kinase, with unique skeletal muscle pathology and magnetic resonance imaging features.In this paper, two patients are reported: One was positive for anti-signal recognition particle antibody, and the other was positive for ...
Chen BH, Zhu XM, Xie L, Hu HQ.
europepmc   +4 more sources

Treatment of refractory immune-mediated necrotizing myopathy with efgartigimod. [PDF]

Front Immunol
Objective We aimed to explore the efficacy and safety of efgartigimod in patients with refractory immune-mediated necrotizing myopathy (IMNM). Methods This open-label pilot observational study included seven patients with refractory IMNM, all of whom ...
Yang M, Yuan J, Wang Y, Hao H, Zhang W, Wang Z, Yuan Y, Zhao Y.   +7 more
europepmc   +5 more sources

Efgartigimod combined with steroids as a fast-acting therapy for anti-SRP immune-mediated necrotizing myopathy [PDF]

Front Neurol
Background Immune-mediated necrotizing myopathy (IMNM) is a rare autoimmune disease. Efgartigimod is a human IgG antibody Fc fragment, can enhance the degradation of IgG and thus may be a promising therapeutic agent for IMNM.
Qiqi Peng, Xiaoping Yao, Sheng Chen, Xiaofeng Li, Feifei Lin, Zhangyu Zou   +5 more
europepmc   +4 more sources

Immune-Mediated Necrotizing Myopathy Diagnosis and Flare in an Adolescent After COVID-19 Vaccine. [PDF]

Clin Case Rep
We discuss a teenager who developed a rare pediatric autoimmune muscle disease after completing the primary COVID‐19 vaccine series, which flared shortly after COVID‐19 booster vaccination.
Hoffman P, Chefitz E, Salvant C, Horton DB.   +3 more
europepmc   +4 more sources

Clinical-pathologic classification of anti-HMGCR-positive immune-mediated necrotizing myopathy. [PDF]

Sci Rep
Anti-HMGCR-positive immune-mediated necrotizing myopathy (IMNM), also anti-HMGCR myopathy, was initially considered as an exclusively skeletal muscular disease, observed in elderly patients with an acute onset.
Cao Y, Li W, He X, Liao M, Hu K, Wu S, Zhang X, Liao Q, Shen Z, Liang Z, Zheng C, Zhong Z, Jiang H, Huang Q, Zheng H.   +14 more
europepmc   +4 more sources

Case report: Rapid clinical improvement of anti-HMGCR immune-mediated necrotizing myopathy treated with efgartigimod. [PDF]

Front Immunol
Immune-mediated necrotizing myopathy (IMNM) with anti-HMGCR antibody positivity is characterized by proximal extremity weakness, increased creatine kinase, and extensive muscle edema. There is an urgent need to find more appropriate treatment options for
Zeng Q, Chen K, Zeng L, Xu L, Tan S.
europepmc   +4 more sources

Immune-Mediated Necrotizing Myopathy (IMNM): A Story of Antibodies. [PDF]

Antibodies (Basel)
Immune-mediated necrotizing myopathy (IMNM) is a rare and severe disease that corresponds to a specific entity of idiopathic inflammatory myopathy. Patients with IMNM suffer from proximal muscle weakness, and present high levels of creatine kinase and ...
Julien S, Challier I, Malleter M, Jouen F, Drouot L, Boyer O.   +5 more
europepmc   +5 more sources