Immune Mediated Necrotizing Myopathy: A Rare Complication of Statin Therapy [PDF]
Clinics and Practice, 2020 Immune mediated necrotizing myopathy (IMNM) is part of the inflammatory myopathies group of diseases and presents with muscle weakness, myalgias and elevated serum creatine phosphokinase (CPK). Statin-induced IMNM is a rare complication. We present a patient with IMNM secondary to simvastatin use. The patient presented with proximal myopathy, dysphagia,
Hyma Polimera +2 more
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Tuberculosis-Induced Immune-Mediated Necrotizing Myopathy: A Challenging Case Scenario in a Non-Endemic Country [PDF]
ReportsBackground and Clinical Significance: Tuberculosis (TB) poses a significant global health challenge; although low–middle income countries carry the heaviest burden, its diagnosis and treatment can be challenging in any country.
Agnese Colpani +5 more
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Immune-mediated necrotizing myopathy: Report of two cases. [PDF]
World J Clin Cases, 2023 Immune-mediated necrotizing myopathy is a rare autoimmune myopathy characterized by muscle weakness and elevated serum creatine kinase, with unique skeletal muscle pathology and magnetic resonance imaging features.In this paper, two patients are reported: One was positive for anti-signal recognition particle antibody, and the other was positive for ...
Chen BH, Zhu XM, Xie L, Hu HQ.
europepmc +3 more sources
Therapeutic Effect Comparisons of Cyclophosphamide and Methotrexate in Immune-Mediated Necrotizing Myopathy [PDF]
International Journal of General MedicineQiang Li,1,* Jun Zhou,2,* Wenhan Huang,2 Lin Tang2 1Department of Rheumatology and Immunology, The First People’s Hospital of Yibin, Yibin, Sichuan, People’s Republic of China; 2Department of Rheumatology and Immunology, The Second ...
Li Q, Zhou J, Huang W, Tang L
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Anti-SRP immune-mediated necrotizing myopathy: A critical review of current concepts
Frontiers in Immunology, 2022 Purpose of reviewThis review aims to describe clinical and histological features, treatment, and prognosis in patients with anti-signal recognition particle (SRP) autoantibodies positive immune-mediated necrotizing myopathy (SRP-IMNM) based on previous ...
Xue Ma, Bi-Tao Bu
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Clinical-pathologic classification of anti-HMGCR-positive immune-mediated necrotizing myopathy [PDF]
Scientific ReportsAnti-HMGCR-positive immune-mediated necrotizing myopathy (IMNM), also anti-HMGCR myopathy, was initially considered as an exclusively skeletal muscular disease, observed in elderly patients with an acute onset.
Yuyan Cao +14 more
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Beyond the Generalized Weakness: A Rare Case of Statin-Induced Immune-Mediated Necrotizing Myopathy [PDF]
Journal of Investigative Medicine High Impact Case ReportsStatin-induced immune-mediated necrotizing myopathy (IMNM) is a rare subtype of idiopathic inflammatory myopathy associated with statin exposure and characterized by positive anti-hydroxymethylglutaryl coenzyme A reductase antibodies. Here, we describe a
Leo Sakai DO +2 more
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An atorvastatin‐induced positive anti‐HMGCR immune‐mediated necrotizing myopathy case [PDF]
Clinical Case ReportsKey Clinical Message Statins can commonly cause myopathy. Most of the time, stopping the culprit drug should solve the problem. However, if the drug has been discontinued but muscle weakness continues to worsen, immune‐mediated myopathy should be taken ...
Nattanicha Chaisrimaneepan +3 more
doaj +2 more sources
Statins and muscle – friends or foes? Discussions based on a case report [PDF]
Romanian Journal of Rheumatology, 2022 Immune-mediated necrotizing myopathy (IMNM) is a type of autoimmune myopathy characterized by relatively severe proximal weakness, myofiber necrosis with minimal inflammatory cell infiltrate on muscle biopsy, and infrequent extra-muscular involvement ...
Andra Patricia Stanciu +2 more
doaj +1 more source
Emerging atypical clinicopathological manifestations of immune-mediated necrotizing myopathy (IMNM) [PDF]
Neuromuscular Disorders, Teerin Liewluck, Andrew Mammen
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