Results 21 to 30 of about 3,889 (160)

Peculiar clinicopathological features of immune-mediated necrotizing myopathies [PDF]

Current Opinion in Rheumatology, 2018
Purpose of reviewIn the past decade, immune-mediated necrotizing myopathies have emerged as a separate entity in the heterogenous group of autoimmune myopathies. This group is characterized by clinical manifestations restricted to the muscle tissue, and until recently, the definition was based on muscular pathological features.Recent findingsIt was ...
Allenbach, Yves, Benveniste, Olivier
openaire   +4 more sources

MRI patterns of thigh muscle involvement in immune-mediated necrotizing myopathy and dermatomyositis. [PDF]

BMC Rheumatol
Background Immune-mediated necrotizing myopathy (IMNM) and dermatomyositis (DM) are characterized by weakness, hyperCKemia, associated autoantibodies, and varying extramuscular manifestations.
Wilks AW, Vakil-Gilani KM, Rooney WD, Choi D, Ghetie D, Chahin N.   +5 more
europepmc   +2 more sources

Immune-mediated necrotizing myopathy due to statins exposure. [PDF]

Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology, 2018
Statin-induced necrotizing autoimmune myopathy (IMNM) is an autoimmune disorder induced by anti-3-hydroxy-3-methylglutaryl-coenzyme-A reductase (anti-HMGCR) antibodies. We performed a retrospective clinical, histological, and radiological evaluation of 5 patients with a 3-year therapeutic follow-up.
Villa, Luisa, Lerario, Alberto, Calloni, Sonia, Peverelli, Lorenzo, Matinato, Caterina, DE Liso, Federica, Ceriotti, Ferruccio, Tironi, Roberto, Sciacco, Monica, Moggio, Maurizio, Triulzi, Fabio, Cinnante, Claudia   +11 more
openaire   +3 more sources

Etiopathogenesis of Immune-Mediated Necrotizing Myopathy: A Comprehensive Review of Recent Advances. [PDF]

CNS Neurosci Ther
This review systematically clarifies that the core of IMNM begins with specific autoantibodies, which in turn trigger complement activation, immune cell infiltration, and a storm of inflammatory factors. Together, these processes induce regulatory cell death and mitochondrial dysfunction, ultimately leading to muscle fiber necrosis. Genetic factors and
Gao C, Li W, Liu Q, Wang G, Peng Q.
europepmc   +2 more sources

Trends in Reports of Statin-Associated Immune-Mediated Necrotizing Myopathy Using the Japanese Adverse Drug Event Report Database. [PDF]

Drugs Real World Outcomes
Background In October 2016, precautions of the package inserts for ethical drugs containing statins were revised for immune-mediated necrotizing myopathy (IMNM).
Takami A, Terashima G, Tajima T, Yamashita K, Igarashi A.   +4 more
europepmc   +2 more sources

Tuberculosis-Induced Immune-Mediated Necrotizing Myopathy: A Challenging Case Scenario in a Non-Endemic Country. [PDF]

Reports (MDPI)
Background and Clinical Significance: Tuberculosis (TB) poses a significant global health challenge; although low–middle income countries carry the heaviest burden, its diagnosis and treatment can be challenging in any country. The clinical picture
Colpani A, Astorri D, De Vito A, Madeddu G, Panese S, Geremia N.   +5 more
europepmc   +2 more sources

Emerging atypical clinicopathological manifestations of immune-mediated necrotizing myopathy (IMNM) [PDF]

Neuromuscular Disorders
Michael P Skolka, , Andrew L Mammen
exaly   +2 more sources

Immune-Mediated Necrotizing Myopathy [PDF]

Current Rheumatology Reports, 2018
Immune-mediated necrotizing myopathy (IMNM) is a type of autoimmune myopathy characterized by relatively severe proximal weakness, myofiber necrosis with minimal inflammatory cell infiltrate on muscle biopsy, and infrequent extra-muscular involvement. Here, we will review the characteristics of patients with IMNM.Anti-signal recognition particle (SRP ...
Iago, Pinal-Fernandez, Maria, Casal-Dominguez, Andrew L, Mammen   +2 more
openaire   +2 more sources

A tough pill to swallow: Two cases of statin-induced necrotizing autoimmune myopathy manifesting as dysphagia and transaminitis [PDF]

, 2023
Although 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase inhibitors are well tolerated, a small subset of patients may develop autoimmune myopathy, classified as immune-mediated necrotizing myopathy.
Joanne Lin, Roytman, Marina, Jeffrey Hagino, Hagino, Jeffrey, Rameen Atefi, Lin, Joanne, Chaudhry, Hunza, Atefi, Rameen, Candice Marie Yuvienco, Marina Roytman, Yuvienco, Candice Marie, Hunza Chaudhry   +11 more
core   +1 more source

Phenotype standardization for statin-induced myotoxicity. [PDF]

, 2014
Statins are widely used lipid-lowering drugs that are effective in reducing cardiovascular disease risk. Although they are generally well tolerated, they can cause muscle toxicity, which can lead to severe rhabdomyolysis.
Fahy, J., Neely, D, Fahy, J, Wadelius, M, Palmer, CN, Carr, D. F., Maitland-van Der Zee, AH, Laaksonen, R, Maitland-van Der Zee, A. H., Wadelius, M., Yue, QY, Chinoy, H.; id_orcid, Psaty, BM, Bloch, K. M., Cooper, R. G., Neely, D., Psaty, B. M., Chinoy, H., Pirmohamed, M., Chinoy, H, Palmer, C. N. A., Voora, D, Palmer, C. N. A.; id_orcid, Voora, D., Armitage, J., Wadelius, Mia,, Yue, Q. Y., Alfirevic, A., Alfirevic, A, Armitage, J, Palmer, C. N A, Pirmohamed, M, Palmer, PN, Hanson, A., Bloch, KM, Laaksonen, R., Cooper, RG, Yue, Q-Y, Wadelius, Mia, Carr, DF, Hanson, A   +40 more
core   +1 more source