Immune-Mediated Necrotizing Myopathy [PDF]
Current Rheumatology Reports, 2018 Immune-mediated necrotizing myopathy (IMNM) is a type of autoimmune myopathy characterized by relatively severe proximal weakness, myofiber necrosis with minimal inflammatory cell infiltrate on muscle biopsy, and infrequent extra-muscular involvement. Here, we will review the characteristics of patients with IMNM.Anti-signal recognition particle (SRP ...
Iago, Pinal-Fernandez +2 more
openaire +2 more sources
Anti-HMGCR positive immune-mediated necrotizing myopathy with associated neutrophilic urticarial dermatosis: A case report [PDF]
JAAD Case ReportsKathleen M. Fletcher, MD +3 more
doaj +2 more sources
Severe Anti-HMG-CoAR Necrotizing Autoimmune Myopathy Secondary to Statin Use
Case Reports in Rheumatology, 2022 Immune-mediated necrotizing myopathy is an uncommon but debilitating disease that can be triggered by drugs, toxins, or cancer. It is similar to polymyositis in presentation but is differentiated by findings on muscle biopsy.
Priyanjali Pulipati +2 more
doaj +1 more source
The myokine GDF-15 is a potential biomarker for myositis and associates with the protein aggregates of sporadic inclusion body myositis. [PDF]
, 2020 Background: The cytokine growth differentiation factor-15 (GDF-15) has been associated with inflammatory and mitochondrial disease, warranting exploration of its expression in myositis patients.
De Bleecker, Jan +2 more
core +2 more sources
A Case Report of Statin-Induced Immune-Mediated Necrotizing Myopathy Treatment Challenges
Case Reports in Rheumatology, 2022 Statin-induced necrotizing autoimmune myopathy is an immune-mediated necrotizing myopathy related to the use of statins. It is a very rare disease, which usually presents with proximal muscle weakness and frank elevation in creatine kinase levels ...
Anwar I. Joudeh +5 more
doaj +1 more source
Immune-Mediated Necrotizing Myopathy Associated With Myelodysplastic Syndrome
Annals of Internal Medicine: Clinical Cases, 2023 Autoimmune diseases can often be diagnosed in patients with myelodysplastic syndrome (MDS). Here, we review the emerging literature linking MDS and rare presentations of autoimmunity, including myositis.
Katherine M. Sheu +3 more
doaj +1 more source
Diagnostics, 2021 Immune-mediated necrotizing myopathy, a new subgroup of inflammatory myopathies, usually begins with subacute onset of symmetrical proximal muscle weakness.
Sunha Park +3 more
doaj +1 more source
Seronegative Immune-Mediated Necrotizing Myopathy: A Case Report
Cureus, 2022 Idiopathic inflammatory myopathies (IIMs) are a group of chronic autoimmune disorders characterized by proximal skeletal muscle weakness. One subtype of the IIMs is immune-mediated necrotizing myopathy (IMNM). IMNM can be further classified according to its autoantibody presence, including anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR ...
Patel, Shriya +2 more
openaire +2 more sources
A recipe for myositis : nuclear factor κB and nuclear factor of activated T-cells transcription factor pathways spiced up by cytokines [PDF]
, 2017 Nuclear factor κB (NF-κB) is a well-known pro-inflammatory transcription factor that regulates the expression of the tissue’s immune-active components, which include cytokines, chemokines and adhesion molecules.
De Paepe, Boel
core +3 more sources
Biomarkers in Inflammatory Myopathies – An Expanded Definition [PDF]
, 2019 Biomarkers as parameters of pathophysiological conditions can be of outmost relevance for inflammatory myopathies. They are particularly warranted to inform about diagnostic, prognostic, and therapeutic questions.
Benveniste, Olivier +2 more
core +3 more sources