Journal of Clinical Rheumatology and Immunology, 2019 We report here a statin naive lady who had refractory myositis for years. The diagnosis was revised to be anti-HMGCR related immune mediated necrotizing myopathy after repeating the muscle biopsy and checking the autoantibody.
Lucas Luk, Ho So
doaj +1 more source
Diagnosis of Statin-Induced Necrotizing Myopathy: Contribution of Anti-HMGCR Antibodies
Acta Médica Portuguesa, 2022 Over the last few years, several cases of statin-induced necrotizing myopathy have been described. This myopathy is characterized by the necrosis of muscle fibers and the presence of anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (anti-HMGCR ...
Cláudia Fidalgo +3 more
doaj +1 more source
Statin-Induced Immune-Mediated Necrotizing Myopathy: An Increasingly Recognized Inflammatory Myopathy [PDF]
Cureus, 2020 Statin-induced immune-mediated necrotizing myopathy, also known as anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (anti-HMGCR) myopathy, is an inflammatory myopathy that is triggered by statin exposure and persists after statin discontinuation. It is a rare side effect of statins, distinct from the more commonly recognized statin-induced myalgia,
Stroie, Oana P +2 more
openaire +2 more sources
Inflammatory myopathies: an update for neurologists
Arquivos de Neuro-Psiquiatria, 2022 Idiopathic inflammatory myopathies (IIM) are a heterogenous group of treatable myopathies. Patients present mainly to the rheumatologist and neurologists, complaining of acute or subacute onset of proximal weakness. Extramuscular manifestations may occur,
André Macedo Serafim Silva +2 more
doaj +1 more source
Myopathy with anti-HMGCR antibodies: Perimysium and myofiber pathology [PDF]
, 2015 OBJECTIVE: To analyze clinical features and myopathology changes in muscle fibers, connective tissue, and vessels in 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) antibody–associated myopathies.
Alshehri, Ali +3 more
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Immune myopathies with perimysial pathology: Clinical and laboratory features [PDF]
, 2018 ObjectiveImmune myopathies with perimysial pathology (IMPP) have a combination of damage to perimysial connective tissue and muscle fiber necrosis, more prominent near the perimysium.
Bucelli, Robert C, Pestronk, Alan
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Sarcoidosis presenting as granulomatous myositis in a 16-year-old adolescent [PDF]
, 2016 BACKGROUND: Sarcoidosis is a multi-system disease characterized by the presence of non-caseating epithelioid granulomas in affected tissues, including skeletal muscle.
Eutsler, Eric Eutsler +4 more
core +2 more sources
An odd case of immune-mediated necrotizing myopathy, complicated with sagittal, transverse and sigmoid sinus thrombosis [PDF]
Balneo and PRM Research Journal, 2023 INTRODUCTION: Immune-mediated necrotizing myopathy (IMNM) is a rare variant of immune-mediated inflammatory myopathy (IMIM) that exhibits a severe prognosis and is unresponsive to conventional treatment.
Andreea Trandafir +3 more
doaj +1 more source
Scanning for therapeutic targets within the cytokine network of idiopathic inflammatory myopathies [PDF]
, 2015 The idiopathic inflammatory myopathies (IIM) constitute a heterogeneous group of chronic disorders that include dermatomyositis (DM), polymyositis (PM), sporadic inclusion body myositis (IBM) and necrotizing autoimmune myopathy (NAM).
De Paepe, Boel, Zschüntzsch, Jana
core +3 more sources
The EuroMyositis registry: an international collaborative tool to facilitate myositis research [PDF]
, 2017 Aims: The EuroMyositis Registry facilitates collaboration across the idiopathic inflammatory myopathy (IIM) research community. This inaugural report examines pooled Registry data.
Andersson, Helena +27 more
core +8 more sources