Results 11 to 20 of about 3,762 (157)
Pediatric immune-mediated necrotizing myopathy [PDF]
Frontiers in Neurology, 2023 Immune-mediated necrotizing myopathy (IMNM) is a type of inflammatory myopathy. Most patients with IMNM produce anti-3-hydroxy-3-methylglutaryl coenzyme A reductase or anti-signal-recognition particle autoantibodies.
Chen-Hua Wang +4 more
doaj +6 more sources
Treatment of refractory immune-mediated necrotizing myopathy with efgartigimod [PDF]
Frontiers in ImmunologyObjectiveWe aimed to explore the efficacy and safety of efgartigimod in patients with refractory immune-mediated necrotizing myopathy (IMNM).MethodsThis open-label pilot observational study included seven patients with refractory IMNM, all of whom ...
MengTing Yang +11 more
doaj +6 more sources
Immune-Mediated Necrotizing Myopathy (IMNM): A Story of Antibodies [PDF]
AntibodiesImmune-mediated necrotizing myopathy (IMNM) is a rare and severe disease that corresponds to a specific entity of idiopathic inflammatory myopathy. Patients with IMNM suffer from proximal muscle weakness, and present high levels of creatine kinase and ...
Sarah Julien +5 more
doaj +6 more sources
Characteristics of cardiac involvement in immune-mediated necrotizing myopathy
Frontiers in Immunology, 2023 ObjectiveTo investigate the characteristics of cardiac involvement due to Immune-mediated Necrotizing Myopathy (IMNM).MethodsPatients diagnosed with Immune-mediated Necrotizing Myopathy (IMNM) who attended the Department of Neurology and the Department ...
Mengyang Liu +5 more
doaj +5 more sources
Treatment of Immune-Mediated Necrotizing Myopathy. [PDF]
Curr Treatm Opt Rheumatol, 2023 Immune-mediated necrotizing myositis (IMNM) is a rare autoimmune disorder characterized by proximal muscle weakness, elevated creatine kinase levels, and necrosis of muscle fibers. While the exact pathogenesis of IMNM remains unknown, anti-HMGCR and anti-SRP autoantibodies are associated with different predisposing factors, clinical manifestations, and
Ogbonnaya-Whittlesey SA +4 more
europepmc +4 more sources
Etiopathogenesis of Immune-Mediated Necrotizing Myopathy: A Comprehensive Review of Recent Advances. [PDF]
CNS Neurosci TherThis review systematically clarifies that the core of IMNM begins with specific autoantibodies, which in turn trigger complement activation, immune cell infiltration, and a storm of inflammatory factors. Together, these processes induce regulatory cell death and mitochondrial dysfunction, ultimately leading to muscle fiber necrosis. Genetic factors and
Gao C, Li W, Liu Q, Wang G, Peng Q.
europepmc +2 more sources
Diagnostics, 2021 Immune-mediated necrotizing myopathy, a new subgroup of inflammatory myopathies, usually begins with subacute onset of symmetrical proximal muscle weakness.
Sunha Park +3 more
doaj +3 more sources
Statins and Immune-Mediated Necrotizing Myopathy
Clinical Management Issues, 2018 Statins are a well-recognized cause of a variety of skeletal myopathic effects, which generally resolve when discontinuing the treatment. Among autoimmune manifestations associated with statins, there is immune-mediated necrotizing myopathy (IMNM).
Mauro Turrin
doaj +4 more sources
SAGE Open Medical Case Reports, 2020 Anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) immune-mediated necrotizing myopathy is a subtype of idiopathic inflammatory myopathy which may be associated with statin exposure.
Darosa Lim +6 more
doaj +2 more sources
MRI patterns of thigh muscle involvement in immune-mediated necrotizing myopathy and dermatomyositis [PDF]
BMC RheumatologyBackground Immune-mediated necrotizing myopathy (IMNM) and dermatomyositis (DM) are characterized by weakness, hyperCKemia, associated autoantibodies, and varying extramuscular manifestations.
Anson W. Wilks +5 more
doaj +2 more sources