Cytokines and chemokines as regulators of skeletal muscle inflammation: presenting the case of Duchenne muscular dystrophy [PDF]
, 2013 Duchenne muscular dystrophy is a severe inherited muscle disease that affects 1 in 3500 boys worldwide. Infiltration of skeletal muscle by inflammatory cells is an important facet of disease pathophysiology and is strongly associated with disease ...
De Bleecker, Jan, De Paepe, Boel
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Peculiar clinicopathological features of immune-mediated necrotizing myopathies [PDF]
Current Opinion in Rheumatology, 2018 Purpose of reviewIn the past decade, immune-mediated necrotizing myopathies have emerged as a separate entity in the heterogenous group of autoimmune myopathies. This group is characterized by clinical manifestations restricted to the muscle tissue, and until recently, the definition was based on muscular pathological features.Recent findingsIt was ...
Allenbach, Yves, Benveniste, Olivier
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Revista Médica Clínica Las Condes, 2018 RESUMEN: Las miopatías inflamatorias son un grupo heterogéneo de enfermedades adquiridas del músculo estriado esquelético que comparten la injuria muscular inmunomediada como característica común.
Jorge A. Bevilacqua, MD, PhD +1 more
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A common missense variant of LILRB5 is associated with statin intolerance and myalgia [PDF]
, 2017 Aims A genetic variant in LILRB5 (leukocyte immunoglobulin-like receptor subfamily-B) (rs12975366: T > C: Asp247Gly) has been reported to be associated with lower creatine phosphokinase (CK) and lactate dehydrogenase (LDH) levels.
Abirami Veluchamy +66 more
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Rambam Maimonides Medical Journal, 2022 Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a rare systemic small-vessel disease, with heterogeneous clinical manifestations. While arthralgia and myalgia are common in the disease course, frank myositis is exceedingly rare.
Noa Hurvitz +6 more
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Studies on the role of autoantibodies and autoantigens in rheumatoid arthritis and myositis [PDF]
, 2016 A major population of patients affected with rheumatoid arthritis (RA) and inflammatory idiopathic myopathies (IIM, collectively called myositis) is characterized by the presence of autoantibodies.
Cerqueira, Cátia
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Current pharmacological treatment of idiopathic inflammatory myopathies [PDF]
, 2016 The idiopathic inflammatory myopathies are uncommon and heterogeneous disorders. Their classification is based on distinct clinicopathologic features.
Alves, SC, Fasano, S, Isenberg, DA
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Aberrant Expression of High Mobility Group Box Protein 1 in the Idiopathic Inflammatory Myopathies
Frontiers in Cell and Developmental Biology, 2020 IntroductionHigh Mobility Group Box Protein 1 (HMGB1) is a DNA-binding protein that exerts inflammatory or pro-repair effects upon translocation from the nucleus.
Jessica Day +16 more
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Localization and expression of nuclear factor of activated T-cells 5 in myoblasts exposed to pro-inflammatory cytokines or hyperosmolar stress and in biopsies from myositis patients [PDF]
, 2018 Aims: Regeneration in skeletal muscle relies on regulated myoblast migration and differentiation, in which the transcription factor nuclear factor of activated T-cells 5 (NFAT5) participates.
Amanda Gonçalves +14 more
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Sporadic inclusion body myositis : an acquired mitochondrial disease with extras [PDF]
, 2019 The sporadic form of inclusion body myositis (IBM) is the most common late-onset myopathy. Its complex pathogenesis includes degenerative, inflammatory and mitochondrial aspects.
De Paepe, Boel
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