Results 41 to 50 of about 3,762 (157)

Diagnosis of Statin-Induced Necrotizing Myopathy: Contribution of Anti-HMGCR Antibodies

Acta Médica Portuguesa, 2022
Over the last few years, several cases of statin-induced necrotizing myopathy have been described. This myopathy is characterized by the necrosis of muscle fibers and the presence of anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (anti-HMGCR ...
Cláudia Fidalgo, Alice Mendes, Rosário Cunha, Fernando Rodrigues   +3 more
doaj   +1 more source

Inflammatory myopathies: an update for neurologists

Arquivos de Neuro-Psiquiatria, 2022
Idiopathic inflammatory myopathies (IIM) are a heterogenous group of treatable myopathies. Patients present mainly to the rheumatologist and neurologists, complaining of acute or subacute onset of proximal weakness. Extramuscular manifestations may occur,
André Macedo Serafim Silva, Eliene Dutra Campos, Edmar Zanoteli   +2 more
doaj   +1 more source

Seronegative Immune-Mediated Necrotizing Myopathy: A Case Report

Cureus, 2022
Idiopathic inflammatory myopathies (IIMs) are a group of chronic autoimmune disorders characterized by proximal skeletal muscle weakness. One subtype of the IIMs is immune-mediated necrotizing myopathy (IMNM). IMNM can be further classified according to its autoantibody presence, including anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR ...
Patel, Shriya, Abu-Abaa, Mohammad, Mousavi, Feryal   +2 more
openaire   +2 more sources

Miopatías inflamatorias

Revista Médica Clínica Las Condes, 2018
RESUMEN: Las miopatías inflamatorias son un grupo heterogéneo de enfermedades adquiridas del músculo estriado esquelético que comparten la injuria muscular inmunomediada como característica común.
Jorge A. Bevilacqua, MD, PhD, Nicholas Earle, MD   +1 more
doaj   +1 more source

A Unique Case of Myositis

Rambam Maimonides Medical Journal, 2022
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a rare systemic small-vessel disease, with heterogeneous clinical manifestations. While arthralgia and myalgia are common in the disease course, frank myositis is exceedingly rare.
Noa Hurvitz, Ariel Kenig, Asa Kessler, Narmine Elkhateeb, Yossef Lerner, Michal Zamir, Fadi Kharouf   +6 more
doaj   +1 more source

Novel Presentation of Aphasia and Tremor in Immune-Mediated Necrotizing Myopathy [PDF]

Cureus, 2021
The authors present a unique case of immune-mediated necrotizing myopathy in a 60-year-old female who presented with aphasia, tremor, and progressive muscular weakness. To the best of our knowledge, the presentation of aphasia and tremor has not been previously reported in immune-mediated necrotizing myopathy. This rare presentation may mimic a variety
Schmuter, Gabriella, Paniagua-Morales, Julian A   +1 more
openaire   +2 more sources

Aberrant Expression of High Mobility Group Box Protein 1 in the Idiopathic Inflammatory Myopathies

Frontiers in Cell and Developmental Biology, 2020
IntroductionHigh Mobility Group Box Protein 1 (HMGB1) is a DNA-binding protein that exerts inflammatory or pro-repair effects upon translocation from the nucleus.
Jessica Day, Jessica Day, Jessica Day, Sophia Otto, Sophia Otto, Kathy Cash, Preethi Eldi, Preethi Eldi, Pravin Hissaria, Pravin Hissaria, Susanna Proudman, Susanna Proudman, Vidya Limaye, Vidya Limaye, John D. Hayball, John D. Hayball, John D. Hayball   +16 more
doaj   +1 more source

Diagnostic utility of inflammatory markers in formalin‐fixed and paraffin‐embedded muscle biopsies for idiopathic inflammatory myopathies

Histopathology, EarlyView.
Formalin‐fixed, paraffin‐embedded (FFPE) muscle tissue supports robust immunohistochemical detection of MHC II, MxA, and p62 with performance comparable to frozen sections. This approach reliably identifies the pathological signatures of inclusion body myositis, dermatomyositis, immune‐mediated necrotizing myopathy, and overlap myositis, enhancing the ...
Chinnawut Suriyonplengsaeng, Jariya Waisayarat   +1 more
wiley   +1 more source

Quantitative Guanidinium CEST‐Based pH Mapping at 3 T in Healthy and Pathological Muscle

NMR in Biomedicine, Volume 39, Issue 8, August 2026.
Chemical exchange saturation transfer (CEST) enables high‐resolution pH mapping by measuring the exchange rate between guanidinium and water protons. The current method is based on the Z‐spectra fitting with Bloch–McConnell (BM) equations and allows us to detect pH variations on the order of 0.02 pH units in the very restrained pathophysiological pH ...
Valentin Henriet, Pierre‐Yves Baudin, Benjamin Marty, Marc Lapert, Harmen Reyngoudt   +4 more
wiley   +1 more source

Peculiar clinicopathological features of immune-mediated necrotizing myopathies [PDF]

Current Opinion in Rheumatology, 2018
Purpose of reviewIn the past decade, immune-mediated necrotizing myopathies have emerged as a separate entity in the heterogenous group of autoimmune myopathies. This group is characterized by clinical manifestations restricted to the muscle tissue, and until recently, the definition was based on muscular pathological features.Recent findingsIt was ...
Allenbach, Yves, Benveniste, Olivier
openaire   +3 more sources