Results 61 to 70 of about 3,762 (157)

Diagnostic and Therapeutic Challenges in Statin‐Induced Necrotizing Autoimmune Myopathy in an Elderly Patient: A Rare Case Report

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT We present the case of a 78‐year‐old woman with metabolic syndrome and a history of multiple ischemic strokes who developed progressive symmetrical proximal muscle weakness, predominantly affecting the lower extremities, while on atorvastatin.
Nischal Shrestha, Abdirahman Hassan, Jennifer Ann Evans   +2 more
wiley   +1 more source

Immune-Mediated Necrotizing Myopathy Manifesting after Five Years of Statin Therapy

Case Reports in Rheumatology, 2023
Immune-mediated necrotizing myopathy (IMNM) is an increasingly common and serious condition in which autoantibodies attack muscle fibers causing clinically significant muscle weakness, fatigue, and myalgias.
Nathan G. DeRon, Francis Fischer, Dylan Lopez, Elizabeth C. Brewer   +3 more
doaj   +1 more source

SAPHO Syndrome Presenting With Severe Inflammatory Back Pain (Sacroiliitis) and Rare Retinol Associated Myopathy in an Iraqi Adolescent Male: A Case Report and Literature Review

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT SAPHO syndrome is a rare autoinflammatory disorder characterized by synovitis, acne, pustulosis, hyperostosis, and osteitis. Although musculoskeletal and dermatologic manifestations are well recognized, extra‐articular involvement remains uncommon, particularly muscular inflammation.
Farah Jaafar Mahdi, Ali Saad Al‐Shammari, Mustafa Majid Hameed, Marwah Sami Ahmed, Ibrahim Khalil, Zahraa Saeed Fahad, Ahmed Dahham Hasan, Nizar Abdulateef Jassim   +7 more
wiley   +1 more source

Pembrolizumab‐Induced Myositis: Diagnostic and Therapeutic Challenges From Two Case Reports and a Narrative Review

Cancer Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background Pembrolizumab, an anti‐PD‐1 immune checkpoint inhibitor, has transformed the treatment of multiple solid tumors. However, it can rarely cause immune‐related myositis, which may involve limb, bulbar, and respiratory muscles, posing a risk of severe morbidity and mortality. Early recognition and management are essential. We report two
Francesca Rifaldi, Niccolò Leandro Alessio, Francesca Caspani, Elena Bolzacchini, Monica Giordano, Paolo Pedrazzoli   +5 more
wiley   +1 more source

Immune-mediated necrotizing myopathy: an emerging disorder

Neurología (English Edition)
To describe the main features and the clinical management of a cohort of patients with immune-mediated necrotizing myopathy (IMNM).We conducted an observational, monocentric, retrospective study of IMNM patients diagnosed in the Neuromuscular Unit of a tertiary hospital in Madrid (Spain) between 2013 and 2021.Sixteen IMNM cases were diagnosed, with a ...
S, Portela-Sánchez, I, Catalina, S, López Muñoz, A, Lozano Ros, A, Sánchez-Soblechero, E, Sola Vendrell, P, Sánchez-Mateos, J L, Muñoz-Blanco   +7 more
openaire   +2 more sources

Immune Mediated Necrotizing Myopathy: a Cause of Isolated Myopathy of Neck Extensor Muscle [PDF]

Clinical Medicine & Research, 2016
Immune mediated necrotizing myopathy (IMNM) is a unique form of myositis that is characterized by distinct muscle biopsy features including abundant myofiber necrosis, degeneration, and regeneration with only minimal, if any, inflammation on muscle biopsy.
Rahul, Sehgal, Rafael, Medina-Flores, Ralph, Yachoui, Charles V, Kenney   +3 more
openaire   +2 more sources

Diabetic myonecrosis complicated by emphysematous pyomyositis and abscess caused by Escherichia coli: a case report

Journal of Medical Case Reports
Background Necrotizing myopathies and muscle necrosis can be caused by immune-mediated mechanisms, drugs, ischemia, and infections, and differential diagnosis may be challenging. Case presentation We describe a case of diabetic myonecrosis complicated by
Anne M. Kerola, Kari K. Eklund, Heikki Valleala, Olli Tynninen, Jaakko Helve, Ville Haapamäki, Mari Eriksson   +6 more
doaj   +1 more source

A case of seronegative immune-mediated necrotizing myopathy

Pifu-xingbing zhenliaoxue zazhi
A case of statin-induced immune necrotizing myopathy with negative autoantibodies is reported. A 67-year-old female presented with generalized weakness and limb muscle soreness for 3 months, with worsening symptoms over the past month.
CUI Lin, XIE Bingxin, ZHANG Shifa
doaj   +1 more source

Anti-3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Immune-Mediated Necrotizing Myopathy following mRNA SARS-CoV-2 Vaccination

Case Reports in Neurological Medicine, 2023
The new coronavirus (COVID-19) pandemic has resulted in the unprecedented production of vaccines. In this context, the possible adverse effects remain to be identified and reported.
Marta Rodrigues de Carvalho, Myrian Mathildes Sá de Deus Rocha, Vinícius Alves Bezerra, Maciel Eduardo de Pontes, Maria Cristina del Negro, Julio Salgado Antunes, Vinícius Viana Abreu Montanaro, Rubens Nelson Morato Fernandez   +7 more
doaj   +1 more source

Ageing‐Associated Dysregulation of Myogenic Differentiation in Inclusion Body Myositis

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 3, June 2026.
ABSTRACT Skeletal muscle is a postmitotic tissue dependent on a complex and tightly regulated regeneration process involving numerous intracellular and extracellular factors, including myogenic regulatory factors (MRFs), cytokines and myokines. Quiescent satellite cells are activated by physiological stimuli, injury or other traumatic insults for the ...
Geert M. de Vries, Willem De Ridder, Jonathan Baets   +2 more
wiley   +1 more source