Results 61 to 70 of about 3,889 (160)

Insights Into the Antigenic Repertoire of Unclassified Synaptic Antibodies

Annals of Clinical and Translational Neurology, Volume 13, Issue 3, Page 547-561, March 2026.
ABSTRACT Objective We sought to characterize the sixth most common finding in our neuroimmunological laboratory practice (tissue assay‐observed unclassified neural antibodies [UNAs]), combining protein microarray and phage immunoprecipitation sequencing (PhIP‐Seq). Methods Patient specimens (258; 133 serums; 125 CSF) meeting UNA criteria were profiled;
Michael Gilligan, John R. Mills, Paulina Vargas, Naveen K. Paramasivan, Connie E. Lesnick, Eati Basal, Surendra Dasari, James P. Fryer, Shannon R. Hinson, Joseph Laporta, Amy Espinal, Dennis Fitzgerald, Carolina Garcia, Anna E. Morenkova, Paola Pergami, Anna Shah, Andrew Knight, Reghann LaFrance Corey, Vanda A. Lennon, Anastasia Zekeridou, Sean J. Pittock, Divyanshu Dubey, Andrew McKeon   +22 more
wiley   +1 more source

Transition From Juvenile Dermatomyositis to Spondyloarthritis: A Novel Overlapping Inflammatory Phenotype

ACR Open Rheumatology, Volume 8, Issue 3, March 2026.
Objective Juvenile dermatomyositis (JDM) is a rare childhood inflammatory myopathy, whereas spondyloarthritis (SpA) is an inflammatory arthropathy characterized by enthesitis and peripheral or axial involvement. We describe a series of patients diagnosed with JDM in childhood who later fulfilled classification criteria for SpA, a sequential phenotype ...
Austen Grooms, Ioannis Karageorgiou, Kerry Mychaliska, James Birmingham   +3 more
wiley   +1 more source

The heterogeneity of immune-mediated necrotizing myopathy illustrated in a cohort of Belgian patients : consequences for diagnosis and disease management

, 2021
Immune-mediated necrotizing myopathy (IMNM), one of the major subtypes of idiopathic inflammatory myopathy, exhibits considerable clinical heterogeneity. The condition’s etiology is autoimmune, yet myopathology reveals prominent muscle fiber necrosis and
De Bleecker, Jan, De Paepe, Boel
core  

Cutaneous involvement in anti-HMGCR positive necrotizing myopathy.

, 2021
OBJECTIVE Anti-3-Hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) positive immune-mediated necrotizing myopathy (IMNM) is a rare disease. It is induced by exogenous substances, most often by statins. Little is known about cutaneous manifestations
Peter M. Villiger, Laurence Feldmeyer, Michael P. Horn, Williams, Barbara, Barbara Williams, Horn, Michael P., Feldmeyer, Laurence, Villiger, Peter M., Banz, Yara, Yara Banz   +9 more
core   +1 more source

Engineering Immune Cell to Counteract Aging and Aging‐Associated Diseases

Advanced Science, Volume 13, Issue 14, 9 March 2026.
This review highlights a paradigm shift in which advanced immune cell therapies, initially developed for cancer, are now being harnessed to combat aging. By engineering immune cells to selectively clear senescent cells and remodel pro‐inflammatory tissue microenvironments, these strategies offer a novel and powerful approach to delay age‐related ...
Jianhua Guo, Lanjie Lei, Ying Jin, Lan Su, Shumao Cui, Liyun Shi   +5 more
wiley   +1 more source

Immune-Mediated Necrotizing Myopathy: A Review for Clinicians

Journal of Electrodiagnosis and Neuromuscular Diseases, 2022
Immune-mediated necrotizing myopathy (IMNM) is a group of inflammatory myopathies showing necrotic and regenerating fibers without noteworthy inflammatory cell infiltration on pathology. The pathologic findings are different from those of dermatomyositis or sporadic inclusion body myositis.
openaire   +1 more source

Challenges in Treating Statin-Associated Necrotizing Myopathy

, 2021
Myalgia and mild elevation in muscle enzymes are common side effects of statin therapy. While these symptoms are generally self-limited, in rare cases, statin use is associated with an immune-mediated necrotizing myopathy caused by development of ...
Michael Lucke, Abdalhamid Al Harash, Nazia Khatoon, Cody Marshall, Patrick Webster, Nicholas Wiemer   +5 more
core   +1 more source

Dermatomyositis Like Presentation of Anti‐HMGCR Immune Mediated Necrotising Myopathy

JEADV Clinical Practice, Volume 5, Issue 1, Page 237-240, March 2026.
Capsule summary Cutaneous manifestations of HMGCR‐IMNM are rare and poorly described. Dermatomyositis‐like rash manifestation can be a presentation of the HMGCR‐IMNM. We report a case with a dermatomyositis‐like presentation and provide a literature review on this topic.
Lionel Leblanc, Lyna Mtimet, Louis Wolff, Evelyne Berlingin, Bruno Couturier   +4 more
wiley   +1 more source

No General Association Between Myositis Antibodies and Electromyography Findings

Neurology and Clinical Neuroscience, Volume 14, Issue 2, Page 160-167, March 2026.
ABSTRACT Objective Myositis‐specific antibodies (MSAs), myositis‐associated antibodies (MAAs), and concentric needle electromyography (EMG) are routinely used in the differential diagnosis of myositis. Their mutual relationship, particularly between MSAs/MAAs and EMG findings, remains unclear.
Benedict Kleiser, Hanna Seifermann, David Hoffmann, Markus C. Kowarik, Evelyn Dubois, Marcel Armbruster, Alexander Grimm, Justus Marquetand   +7 more
wiley   +1 more source

Statin-induced necrotizing myositis - A discrete autoimmune entity within the "statin-induced myopathy spectrum"

, 2013
Statin-induced necrotizing myositis is increasingly being recognised as part of the "statin-induced myopathy spectrum". As in other immune-mediated necrotizing myopathies, statin-induced myositis is characterised by proximal muscle weakness with marked ...
Hamann, Philip D H, Chinoy, Hector; id_orcid, Cooper, Robert G., McHugh, Neil J.   +3 more
core   +1 more source