Results 81 to 90 of about 2,380,685 (149)

Immune-mediated necrotizing myopathy due to statins exposure [PDF]

, 2018
Statin-induced necrotizing autoimmune myopathy (IMNM) is an autoimmune disorder induced by anti-3-hydroxy-3-methylglutaryl-coenzyme-A reductase (anti-HMGCR) antibodies. We performed a retrospective clinical, histological, and radiological evaluation of 5
Ceriotti, Ferruccio, Triulzi, Fabio, Cinnante, Claudia, Moggio, Maurizio, Villa, Luisa, Calloni, Sonia, DE Liso, Federica, Peverelli, Lorenzo, Matinato, Caterina, Tironi, Roberto, Lerario, Alberto, Sciacco, Monica   +11 more
core  

Immune-Mediated Necrotizing Myopathy in Association with Statin Exposure

Statins are first-line therapy for hyperlipidemia and are widely prescribed in primary care. Although generally safe, they carry rare but serious risks that must be considered on an individual basis.
Rossi, Phebie, Babcock, Charlie E, Hasvold, Jennifer   +2 more
core   +1 more source

Autophagy markers LC3 and p62 accumulate in immune‐mediated necrotizing myopathy

, 2019
Introduction: The molecular mechanism of immune-mediated necrotizing myopathy (IMNM) remains unknown. Autophagy impairment, described in autoimmune diseases, is a key process in myofibre protein degradation flux and muscle integrity, and has not been ...
Anna, Lia, Domenico, Ribatti, Florenzo, Iannone, Luigi, Serlenga, Tiziana, Annese, Angela, Amati, Marilina, Tampoia, Dario, D'Abbicco, Maria, Trojano, Margherita, Giannini, Francesco, Girolamo, Daniela, Virgintino   +11 more
core   +1 more source

Modulation of human immune responses by bovine interleukin-10 [PDF]

, 2011
Cytokines can be functionally active across species barriers. Bovine IL-10 has an amino acid sequence identity with human IL-10 of 76.8%. Therefore, the aim of this study was to evaluate whether bovine IL-10 has immunomodulatory activities on human ...
Schoemaker, R., de Ruiter, T., Weg-Schrijver, Elise, van de, Westphal Adrie H., Tijhaar, E., Savelkoul, H.F.J., Adrie H Westphal, Westphal, A.H., Savelkoul Huub F. J., R J Joost van Neerven, Edwin Tijhaar, Neerven, R.J.J., van, Gerco den Hartog, van de Weg-Schrijver Elise, Schoemaker Ruud, den Hartog Gerco, den Hartog, C.G., Huub F J Savelkoul, van de Weg-Schrijver, Elise, Talitha de Ruiter, Elise van de Weg-Schrijver, de Ruiter Talitha, Ruiter, T., de, Ruud Schoemaker, van Neerven, R.J.J., Hartog, C.G., den, Tijhaar Edwin, van Neerven R. J. Joost   +27 more
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Immune-Mediated Megaconial Myopathy: A Novel Subtype of Autoimmune Myopathy. [PDF]

OBJECTIVES: To describe a novel subtype of autoimmune myopathy, immune-mediated megaconial myopathy (IMMM), myopathologically characterized by giant mitochondria (megaconia).
Raslan, Wasim F, Santilli, Ashley R, Alkhalifah, Moayd M, Selcen, Duygu, Hsieh, Christine, Alenezi, Raed M, Liewluck, Teerin, Seth, Arjun, Mehrabyan, Anahit C, Milone, Margherita, Nicolau, Stefan, Soontrapa, Pannathat, Ni, Oliver   +12 more
core   +1 more source

A Case Report of Anti–3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Immune-Mediated Necrotizing Myopathy

We present a 75-year-old woman with 3 months of progressive proximal muscle weakness, myalgias, and dysphagia. Her admission was complicated by acute hypoxic respiratory failure requiring admission to the intensive care unit.
Monique Crawford, Xiaoshan Gong, Sachin Chaudhary, Johnny M. Trinh   +3 more
core   +1 more source

Peculiar clinicopathological features of immune-mediated necrotizing myopathies

, 2018
International audiencePurpose of review In the past decade, immune-mediated necrotizing myopathies have emerged as a separate entity in the heterogenous group of autoimmune myopathies.
Olivier Benveniste, Allenbach, Yves, Benveniste, Olivier, Yves Allenbach   +3 more
core   +1 more source

A SPONTANEOUS MOUSE MODEL OF X-LINKED MYOPATHY WITH EXCESSIVE AUTOPHAGY [PDF]

, 2011
the subject of the thesis research project, aims to characterize a murine model for spontaneous muscle pathology comparable to human "X-Linked Vacuolar myopathy with Excessive Autophagy (XMEA)".
Iovane, Valentina
core   +1 more source

"STATINS KALEIDOSCOPE". MYOPATHY FROM STATINS [PDF]

, 2019
Statins are medications that inhibit the 3-hydroxy-3-methylglutaryl-CoA reductase enzyme, thus inhibiting cholesterol biosynthesis. Statins reduce cardiovascular risk and morbidity in patients with coronaropathia, however, without forgetting their side ...
NUHAJ, LEDIANA, ZOTO, ARTUR, RAPUSHI, ERVIN, BACKA, TEUTA, XHEMALI, INDIN   +4 more
core   +1 more source

Statin-Associated Muscle Symptoms and Myotoxicity: A Clinically Oriented Narrative Review with a Practical Prevention, Evaluation, and Management Algorithm

Medicina
Background and Objectives: Muscle symptoms are the most visible adverse event attributed to statins, but terminology is often imprecise. Most patients report myalgia or nonspecific aches, whereas objective myopathy, inflammatory or necrotizing myositis ...
Francisco Epelde
doaj   +1 more source