Screening for Anti-HMGCR Antibodies in a Large Single Myositis Center Reveals Infrequent Exposure to Statins and Diversiform Presentation of the Disease [PDF]
Frontiers in Immunology, 2022 BackgroundThe objective of this study is to assess the frequency of autoantibodies against 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMGCR) in a single center myositis cohort and to analyze associations with statin exposure, clinical features ...
Olof Danielsson +2 more
exaly +4 more sources
Prevention of Anti-HMGCR Immune-Mediated Necrotising Myopathy by C5 Complement Inhibition in a Humanised Mouse Model [PDF]
Biomedicines, 2022 Introduction: immune-mediated necrotising myopathy (IMNM) is associated with pathogenic anti-signal recognition particle (SRP) or 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) antibodies, at least partly through activation of the classical pathway of ...
Olivier Boyer +2 more
exaly +4 more sources
Anti-HMGCR myopathy: a first case report from North Africa and literature insights [PDF]
Frontiers in ImmunologyAnti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (anti-HMGCR) myopathy is a rare idiopathic inflammatory myopathy characterized by severe muscle damage and minimal extra-muscular involvement.
Samar Samoud +2 more
exaly +4 more sources
Anti-HMGCR-Antibody-Positive Statin-Induced Myositis: A Pilot Case Series on Treatment with Bempedoic Acid and Immunosuppressive Therapy [PDF]
AntibodiesBackground/Objectives: Immune-mediated necrotizing myopathy (IMNM) is a severe inflammatory myopathy marked by proximal muscle weakness, elevated creatine kinase (CK), and the presence of anti-HMGCR antibodies. Statin exposure is a recognized trigger for
Maurizio Benucci +2 more
exaly +4 more sources
Statin-associated anti-HMGCR immune-mediated necrotizing myopathy with dermatomyositis-like features: A case report [PDF]
SAGE Open Medical Case Reports, 2020 Anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) immune-mediated necrotizing myopathy is a subtype of idiopathic inflammatory myopathy which may be associated with statin exposure.
Annie Genois +2 more
exaly +3 more sources
Clinical-pathologic classification of anti-HMGCR-positive immune-mediated necrotizing myopathy [PDF]
Scientific ReportsAnti-HMGCR-positive immune-mediated necrotizing myopathy (IMNM), also anti-HMGCR myopathy, was initially considered as an exclusively skeletal muscular disease, observed in elderly patients with an acute onset.
Yuyan Cao +14 more
exaly +3 more sources
Anti-HMGCR Specificity of HALIP: A Confirmatory Study [PDF]
Journal of Immunology Research, 2020 A distinctive new indirect immunofluorescence pattern in liver tissue has been associated with anti-HMGCR autoantibodies. It is known as HALIP (HMGCR Associated Liver Immunofluorescence Pattern).
Andrés Baucells +6 more
doaj +2 more sources
Association of anti-HMGCR antibodies of the IgM isotype with refractory immune-mediated necrotizing myopathy [PDF]
Arthritis Research & TherapyObjective Anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) autoantibodies are one of the myositis-specific antibodies which is associated with immune-mediated necrotizing myopathy (IMNM).
Hongxia Yang +7 more
doaj +2 more sources
Atypical skin conditions of the neck and back as a dermal manifestation of anti-HMGCR antibody-positive myopathy [PDF]
BMC ImmunologyBackground Immune-mediated necrotizing myopathy (IMNM) is an idiopathic inflammatory myopathy (IIM). Though patients with IMNM were not considered to show skin rash, several reports have showed atypical skin conditions in patients with anti-3-hydroxy-3 ...
Takashi Kurashige +9 more
doaj +2 more sources
Case report: Rapid clinical improvement of anti-HMGCR immune-mediated necrotizing myopathy treated with efgartigimod [PDF]
Frontiers in ImmunologyImmune-mediated necrotizing myopathy (IMNM) with anti-HMGCR antibody positivity is characterized by proximal extremity weakness, increased creatine kinase, and extensive muscle edema. There is an urgent need to find more appropriate treatment options for
Quantao Zeng +5 more
doaj +2 more sources