Results 31 to 40 of about 1,954,791 (139)

Clinical characteristics of myositis patients with isolated anti-U1 ribonucleoprotein antibody resemble immune-mediated necrotizing myopathy

Therapeutic Advances in Musculoskeletal Disease, 2023
Background: Anti-U1 ribonucleoprotein (U1RNP) antibodies were associated with connective tissue diseases (CTDs), but the clinical characteristics of this antibody in Chinese myositis patients have not been studied.
Yongpeng Ge, Hongxia Yang, Wei Jiang, Xiaolan Tian, Xin Lu, Guochun Wang   +5 more
doaj   +1 more source

Fuzzy optimization for identifying anti-cancer targets with few side effects in constraint-based models of head and neck cancer

Royal Society Open Science, 2022
Computer-aided methods can be used to screen potential candidate targets and to reduce the time and cost of drug development. In most of these methods, synthetic lethality is used as a therapeutic criterion to identify drug targets.
Feng-Sheng Wang, Pei-Rong Chen, Ting-Yu Chen, Hao-Xiang Zhang   +3 more
doaj   +1 more source

Case Report: Immune Mediated Necrotizing Myopathy With IgG Antibodies to 3-Hydroxy-3-Methylglutaryl-Coenzyme a Reductase (HMGCR) May Present With Acute Systolic Heart Failure

Frontiers in Neurology, 2020
Involvement of cardiac muscle is felt to be very uncommon in anti-HMGCR myopathy, and therefore early cardiac evaluation is not considered a high priority for this condition.
Malik Ghannam, Georgios Manousakis
doaj   +1 more source

Increased small extracellular vesicle secretion after chemotherapy via upregulation of cholesterol metabolism in acute myeloid leukaemia

Journal of Extracellular Vesicles, 2020
Most patients with acute myeloid leukaemia (AML) experience disease recurrence after chemotherapy largely due to the development of drug resistance. Small extracellular vesicles (sEVs) are known to play a significant role in leukaemia drug resistance by ...
Chang-Sook Hong, Emily Jeong, Michael Boyiadzis, Theresa L. Whiteside   +3 more
doaj   +1 more source

Anti-HMGCR myopathy may resemble limb-girdle muscular dystrophy

, 2018
International audienceObjective To determine the prevalence and clinical features of anti-HMGCR myopathy among patients with presumed limb-girdle muscular dystrophy (LGMD) in whom genetic testing has failed to elucidate causative mutations.
Fequiere, Pierre, Béhin, Anthony, Stojkovic, Tanya, Bönnemann, Carsten, Bönnemann, Carsten G, Toro, Camilo, Harper, Amy, Drachman, Daniel, Shebert, Robert T, Lafôret, Pascal, Pak, Katherine S, Foley, A Reghan, Mohassel, Payam, Wahl, Colleen, Eymard, Bruno, Mammen, Andrew L, Mammen, Andrew, Benveniste, Olivier, Pak, Katherine, Donkervoort, Sandra, Foley, A. Reghan, Meriggioli, Matthew, Landon-Cardinal, Océane, Allenbach, Yves, Shebert, Robert   +24 more
core   +1 more source

A Case of Refractory Myositis

Journal of Clinical Rheumatology and Immunology, 2019
We report here a statin naive lady who had refractory myositis for years. The diagnosis was revised to be anti-HMGCR related immune mediated necrotizing myopathy after repeating the muscle biopsy and checking the autoantibody.
Lucas Luk, Ho So
doaj   +1 more source

Long Noncoding RNA PCALRx Interacts with Pyruvate Carboxylase to Drive Multi‐Organ Developmental Toxicity in Zebrafish Embryos Exposed to Amoxicillin

Advanced Science, EarlyView.
Embryonic amoxicillin exposure disrupts multi‐organ development in zebrafish larvae through a lncRNA–metabolic enzyme regulatory axis. PCALRx associates with pyruvate carboxylase, promotes PC protein ubiquitination, and impairs mitochondrial energy metabolism, while vitamin B1 partially restores PC‐centered metabolic function and developmental outcomes.
Yixue Yao, Ping Jiang, Xinli Zhou, Mengying Yin, Qiong Luo, Hui Wang   +5 more
wiley   +1 more source

Supramolecular Degraders: An Emerging Paradigm in Targeted Protein Degradation

Advanced Science, EarlyView.
Dynamic supramolecular assembly reshapes targeted protein degradation by coordinating modular degrader construction, delivery, functional integration, and intracellular assembly or activation across proteasomal, endosomal–lysosomal, and autophagy–lysosomal pathways.
Kongjun Liu, Xue Yuan, Yan Zhou, Rui Yuan, Shaocheng Xie, Yong Chen, Peiyi Wang, Jianmei Gao, Qihai Gong   +8 more
wiley   +1 more source

Emerging roles of the metabolic regulator 3-hydroxy-3-methylglutaryl coenzyme-CoA reductase in human cancers: From biology to therapeutics

Genes and Diseases
Tumor cells alter several critical metabolic pathways to satisfy their demands for rapid proliferation and survival. Maladjustment of cholesterol metabolism is present in diverse types of tumor cells.
Wenfang Li, Jianxiong Xu, Yuxuan Long, Han Zhang, Xiaojuan Rong, Zhengding Su   +5 more
doaj   +1 more source

OAF Blocks SIAH1‐Mediated Degradation of SCPX, a Therapeutic Strategy for MASLD

Advanced Science, EarlyView.
This study shows OAF directly binds to SCPX and inhibits its interaction with the E3 ligase SIAH1, thereby protecting SCPX from ubiquitin‐dependent degradation and stabilizing its levels. This OAF‐SCPX axis represents a novel pathway in lipid homeostasis, highlighting OAF as a promising therapeutic candidate for MASLD.
Zongxi Li, Jingyue Song, Kaili Ma, Shunan Tang, Shuqian Wang, Wenya Ji, Chen Lu, Ting Zhang, Huaping Zheng, Xiaowei Zheng, Shanshan Lai, Cheng Deng   +11 more
wiley   +1 more source