Screening for Anti-HMGCR Antibodies in a Large Single Myositis Center Reveals Infrequent Exposure to Statins and Diversiform Presentation of the Disease [PDF]
Frontiers in Immunology, 2022 BackgroundThe objective of this study is to assess the frequency of autoantibodies against 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMGCR) in a single center myositis cohort and to analyze associations with statin exposure, clinical features ...
Piotr Szczesny +7 more
doaj +5 more sources
Association of anti-HMGCR antibodies of the IgM isotype with refractory immune-mediated necrotizing myopathy [PDF]
Arthritis Research & TherapyObjective Anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) autoantibodies are one of the myositis-specific antibodies which is associated with immune-mediated necrotizing myopathy (IMNM).
Hongxia Yang +7 more
doaj +5 more sources
Anti-HMGCR antibodies and asymptomatic hyperCKemia. A case report. [PDF]
Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology, 2021 Anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) related myositis is a form of immune-mediated necrotizing myopathy (IMNM). Anti-HMGCR autoantibodies target HMGCR, a glycoprotein linked to the endoplasmic reticulum implied in the cholesterol synthesis pathway, and exert a pathogenic effect on skeletal muscle cells. More than 60% of patients
Torri F. +4 more
europepmc +4 more sources
AntibodiesBackground/Objectives: Immune-mediated necrotizing myopathy (IMNM) is a severe inflammatory myopathy marked by proximal muscle weakness, elevated creatine kinase (CK), and the presence of anti-HMGCR antibodies. Statin exposure is a recognized trigger for
Maurizio Benucci +8 more
doaj +7 more sources
Anti-HMGCR antibodies in systemic sclerosis [PDF]
Medicine (United States), 2016 The objective of this study was to investigate the frequency of autoantibodies to hydroxymethylglutaryl coenzyme A reductase (HMGCR) in systemic sclerosis (SSc) and associations with inflammatory myositis and statin exposure.This was a cross-sectional, multicenter study of 306 subjects from the Canadian Scleroderma Research Group cohort who had ...
Marie Hudson +2 more
exaly +4 more sources
Statins and myositis: the role of anti-HMGCR antibodies [PDF]
Expert Review of Clinical Immunology, 2015 Muscle toxicity is a recognized adverse effect of statin use. Recently, a new myositis syndrome was described in association with antibodies directed against the pharmacologic target of statins, anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (anti-HMGCR antibody).
Albert Selva-O'Callaghan
exaly +4 more sources
Diagnosis of Statin-Induced Necrotizing Myopathy: Contribution of Anti-HMGCR Antibodies
Acta Médica Portuguesa, 2022 Over the last few years, several cases of statin-induced necrotizing myopathy have been described. This myopathy is characterized by the necrosis of muscle fibers and the presence of anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (anti-HMGCR ...
Cláudia Fidalgo +3 more
doaj +4 more sources
Pediatric case of immune-mediated necrotizing myopathy with anti-HMGCR antibodies and dermatomyositis skin rash [PDF]
Pediatric Rheumatology Online JournalThéau Cavillon +6 more
doaj +4 more sources
Myopathy with anti-HMGCR antibodies [PDF]
Neurology Neuroimmunology & Neuroinflammation, 2015 To analyze clinical features and myopathology changes in muscle fibers, connective tissue, and vessels in 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) antibody-associated myopathies.Retrospective review of records and myopathologic features of 49 consecutive patients with myopathies and serum HMGCR antibodies.Clinical features included onset
Alshehri, Ali +3 more
openaire +4 more sources
Initial seronegative immune-mediated necrotising myopathy with subsequent anti-HMGCR antibody development and response to rituximab: case report [PDF]
BMC Rheumatology, 2020 Background Immune-mediated necrotising myopathy (IMNM) is characterised by severe muscle weakness and necrosis with a paucity of inflammation on muscle biopsy. Around 60% of cases are associated with antibodies to the signal recognition particle (SRP) or
Rhys Thomas +6 more
doaj +3 more sources