Results 11 to 20 of about 2,269,213 (187)

Prevention of Anti-HMGCR Immune-Mediated Necrotising Myopathy by C5 Complement Inhibition in a Humanised Mouse Model

Biomedicines, 2022
Introduction: immune-mediated necrotising myopathy (IMNM) is associated with pathogenic anti-signal recognition particle (SRP) or 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) antibodies, at least partly through activation of the classical pathway of ...
Sarah Julien, Douangsone Vadysirisack, Camil Sayegh, Sharan Ragunathan, Yalan Tang, Emma Briand, Marion Carrette, Laetitia Jean, Rachid Zoubairi, Henri Gondé, Olivier Benveniste, Yves Allenbach, Laurent Drouot, Olivier Boyer   +13 more
doaj   +4 more sources

Anti-HMGCR Specificity of HALIP: A Confirmatory Study [PDF]

Journal of Immunology Research, 2020
A distinctive new indirect immunofluorescence pattern in liver tissue has been associated with anti-HMGCR autoantibodies. It is known as HALIP (HMGCR Associated Liver Immunofluorescence Pattern).
Andrés Baucells, Maria Angeles Martínez, Marcelo Alvarado-Cardenas, Anaís Mariscal, Laura Martinez-Martinez, Cándido Juárez, Albert Selva-O’Callaghan   +6 more
doaj   +2 more sources

Anti-HMGCR Antibody-Positive Myopathy Shows Bcl-2-Positive Inflammation and Lymphocytic Accumulations [PDF]

Journal of Neuropathology and Experimental Neurology, 2020
Abstract Anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) and antisignal recognition particle (SRP) antibodies are frequently associated with immune-mediated necrotizing myopathy (IMNM). However, the difference in clinical manifestations between anti-HMGCR and anti-SRP antibodies is unclear.
Tetsuya Takahashi, Hirofumi Maruyama, Takashi Kurashige   +2 more
exaly   +3 more sources

Case Report: Immune Mediated Necrotizing Myopathy With IgG Antibodies to 3-Hydroxy-3-Methylglutaryl-Coenzyme a Reductase (HMGCR) May Present With Acute Systolic Heart Failure

Frontiers in Neurology, 2020
Involvement of cardiac muscle is felt to be very uncommon in anti-HMGCR myopathy, and therefore early cardiac evaluation is not considered a high priority for this condition.
Malik Ghannam, Georgios Manousakis
doaj   +3 more sources

Clinical characteristics in antibody-positive pediatric patients with immune-mediated necrotizing myopathy [PDF]

Italian Journal of Pediatrics
Objective To investigate the clinical characteristics and therapeutic strategies of childhood immune-mediated necrotizing myopathy (IMNM) and to provide evidence for clinical diagnosis and management.
Yiwen Xu, Zhanwei Zhang, Yixuan Chu, Fang He, Leilei Mao, Li Yang, Fei Yin, Jing Peng, Lifen Yang, Ciliu Zhang   +9 more
doaj   +2 more sources

Seronegative Granulomatous Myositis With Bulbar Weakness and Reversible Cardiomyopathy: A Case Report [PDF]

Clinical Case Reports, Volume 14, Issue 9, September 2026.
ABSTRACT A 64‐year‐old woman presented with seronegative idiopathic granulomatous myositis, featuring severe bulbar weakness, reversible cardiomyopathy (ejection fraction 20%–25%), hepatic injury, and acute kidney injury. Muscle biopsy confirmed granulomatous inflammation.
Balachandran R. Vaidyanathan, Muhamed Abubacker, John Ponugupati   +2 more
wiley   +2 more sources

Case Report: Balancing immunosuppression and infection—intravenous immunoglobulin in anti-HMGCR immune-mediated necrotizing myopathy complicated by severe pneumonia [PDF]

Frontiers in Medicine
A 65-year-old male with a 3-year history of atorvastatin use presented with progressive proximal muscle weakness, dysphagia, and markedly elevated creatine kinase (2,277 U/L).
Jing Fu, Qiong Zhao, Jing-Bo Lou, Gui-Hua Tang, Wei Chen, Jiang-Hu Zhao, Qian-Song He   +6 more
doaj   +2 more sources

Diagnostic and Therapeutic Challenges in Statin‐Induced Necrotizing Autoimmune Myopathy in an Elderly Patient: A Rare Case Report [PDF]

Clinical Case Reports
We present the case of a 78‐year‐old woman with metabolic syndrome and a history of multiple ischemic strokes who developed progressive symmetrical proximal muscle weakness, predominantly affecting the lower extremities, while on atorvastatin. Laboratory
Nischal Shrestha, Abdirahman Hassan, Jennifer Ann Evans   +2 more
doaj   +2 more sources

Anti-HMGCR Antibody–Related Necrotizing Autoimmune Myopathy Mimicking Muscular Dystrophy

Neuropediatrics, 2017
Introduction Necrotizing autoimmune myopathies (NAMs) are acquired myopathies with myofibrillar necrosis and weak or absent inflammatory component, sometimes associated with anti-signal recognition particle (SRP) or 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) antibodies.
Tard, Céline, Tiffreau, Vincent, Jaillette, Emmanuelle, Jouen, Fabienne, Nelson, Isabelle, Bonne, Gisèle, Ben Yaou, Rabah, Romero, Norma, Vallée, Louis, Vermersch, Patrick, Nguyen, Sylvie, Maurage, Claude-Alain, Cuisset, Jean-Marie   +12 more
openaire   +5 more sources

Proposed cut-off for reactivity of anti-HMGCR and anti-SRP antibodies in patients statin-exposed and statin-unexposed

Medicine (United States), 2018
The therapeutic approach with statins is widely used in the control of dyslipidemias. However, there is no laboratory evaluation to elect patients to make use of this class of therapeutic drugs.We analyzed the prevalence of anti-signal recognition particle (anti-SRP) and anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (anti-HMGCR) antibodies in a ...
Vinicius Gomes da Silva
exaly   +3 more sources