Results 21 to 30 of about 2,269,213 (187)

Statin-Induced Immune-Mediated Necrotizing Myopathy with Anti-HMGCR Antibody [PDF]

Korean Journal of Neuromuscular Disorders, 2021
Anti-3-hydroxy-3-methylglutaryl coenzyme A reductase (anti-HMGCR) antibody related immune-mediated necrotizing myopathy (IMNM) are usually associated with statin use. The disease has features of persistent muscle weakness and creatine kinase (CK) elevation after statin discontinuation.
Jeongjae Lee, Euihyun Kim, Nahee Kim, Hyung Jun Park, Yoo Hwan Kim   +4 more
openaire   +1 more source

Clinical Characteristics of Anti-3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Antibodies in Chinese Patients with Idiopathic Inflammatory Myopathies. [PDF]

PLoS ONE, 2015
The objective of this study was to detect the prevalence of anti-3-hydroxyl-3- methylglutaryl coenzyme A reductase (anti-HMGCR) antibodies in Chinese patients with idiopathic inflammatory myopathies (IIMs), and to analyze the clinical features of the ...
Yongpeng Ge, Xin Lu, Qinglin Peng, Xiaoming Shu, Guochun Wang   +4 more
doaj   +1 more source

Clinical characteristics of myositis patients with isolated anti-U1 ribonucleoprotein antibody resemble immune-mediated necrotizing myopathy

Therapeutic Advances in Musculoskeletal Disease, 2023
Background: Anti-U1 ribonucleoprotein (U1RNP) antibodies were associated with connective tissue diseases (CTDs), but the clinical characteristics of this antibody in Chinese myositis patients have not been studied.
Yongpeng Ge, Hongxia Yang, Wei Jiang, Xiaolan Tian, Xin Lu, Guochun Wang   +5 more
doaj   +1 more source

Case report: Diagnostic clues for anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase myopathy in pediatric patients

Frontiers in Pediatrics, 2023
IntroductionAnti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) myopathy is a recently recognized pathology, but appears less common in children and the characteristics of pediatric cases remain unclear.Case reportWe report a pediatric case of ...
Keisuke Watanuki, Hiroshi Koga
doaj   +1 more source

A case of anti-HMGCR myopathy in a patient with breast cancer and anti-Th/To antibodies

Oxford Medical Case Reports, 2023
Abstract Statins competitively inhibit the activity of HMGCR (3-hydroxy-3-methylglutaryl coenzyme A reductase), which is a key enzyme in cholesterol synthesis. These are effective drugs for the management of cardiovascular disease and are generally well tolerated but several side effects have been reported.
Mohammad Yassine Chérif, Ioannis Raftakis, Marjolaine Weynand, Elena Dragan, Carole Nagant, Sophie Lecomte, Valérie Badot   +6 more
openaire   +2 more sources

Cancer association as a risk factor for anti-HMGCR antibody-positive myopathy [PDF]

Neurology Neuroimmunology & Neuroinflammation, 2016
To show cancer association is a risk factor other than statin exposure for anti-3-hydroxy-3-methylglutaryl coenzyme A reductase autoantibody-positive (anti-HMGCR Ab+) myopathy.We analyzed the clinical features and courses of 33 patients (23 female and 10 male) with anti-HMGCR Ab+ myopathy among 621 consecutive patients with idiopathic inflammatory ...
Kadoya, Masato, Hida, Ayumi, Hashimoto Maeda, Meiko, Taira, Kenichiro, Ikenaga, Chiseko, Uchio, Naohiro, Kubota, Akatsuki, Kaida, Kenichi, Miwa, Yusuke, Kurasawa, Kazuhiro, Shimada, Hiroyuki, Sonoo, Masahiro, Chiba, Atsuro, Shiio, Yasushi, Uesaka, Yoshikazu, Sakurai, Yasuhisa, Izumi, Toru, Inoue, Manami, Kwak, Shin, Tsuji, Shoji, Shimizu, Jun   +20 more
openaire   +3 more sources

Anti-HMGCR myopathy: barriers to prompt recognition [PDF]

, 2022
Anti-HMGCR (3-hydroxy-3-methylglutaryl coenzyme A reductase) myopathy is an immune-mediated necrotising myopathy. Atypical presentations hinder its recognition and its prompt treatment.
Barp, Andrea, Hanna, Michael G, Merve, Ashirwad, Bugiardini, Enrico, Shah, Sachit, Desikan, Mahalekshmi   +5 more
core   +1 more source

The Clinicopathological Distinction Between Seropositive and Seronegative Immune-Mediated Necrotizing Myopathy in China

Frontiers in Neurology, 2021
Objectives: The present study aimed to compare the clinicopathological features of patients with seronegative immune-mediated necrotizing myopathy (IMNM) and those positive for anti-signal recognition particle (SRP) or anti-3-hydroxy-3 ...
Xue Ma, Li Xu, Suqiong Ji, Yue Li, Bitao Bu   +4 more
doaj   +1 more source

Clinical course and treatment of anti-HMGCR antibody–associated necrotizing autoimmune myopathy [PDF]

Neurology Neuroimmunology & Neuroinflammation, 2015
We examined a cohort of Australian patients with statin exposure who developed a necrotizing autoimmune myopathy (NAM) associated with a novel autoantibody against 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) and describe the clinical and therapeutic challenges of managing these patients and an optimal therapeutic strategy.Clinical ...
Ramanathan, Sudarshini, Langguth, Daman, Hardy, Todd A., Garg, Nidhi, Bundell, Chris, Rojana-Udomsart, Arada, Dale, Russell C., Robertson, Thomas, Mammen, Andrew L., Reddel, Stephen W.   +9 more
openaire   +2 more sources

Neuropathophysiological potential of Guillain-Barré syndrome anti-ganglioside-complex antibodies at mouse motor nerve terminals [PDF]

, 2011
Objectives:  Anti-ganglioside antibodies are present in approximately half of Guillain–Barré syndrome (GBS) patients. Recently, it has been shown that a considerable proportion of these patients has serum antibodies against antigenic epitopes formed by a
Susumu Kusunoki, Tio-Gillen, Anne P., Plomp, J.J., Kusunoki, Susumu, Tio-Gillen, A.P., Willison, H.J., Broos, Ludo A.M., Ueda, M., Mark L. Kuijf, Ludo A. M. Broos, Kuijf, Mark L., Jacobs, B.C., Greenshields, Kay N., Jacobs, Bart C., Zitman, F.M.P., Hugh J. Willison, Anne P. Tio-Gillen, Masami Ueda, Kuijf, M.L., Jaap J. Plomp, Kusunoki, S., Greenshields, K.N., Plomp, Jaap J., Femke M. P. Zitman, Broos, L.A.M., Kay N. Greenshields, Ken-ichi Kaida, Willison, Hugh J., Bart C. Jacobs, Kaida, Ken Ichi, Kaida, K.I., Ueda, Masami, Zitman, Femke M.P.   +32 more
core   +1 more source