Results 31 to 40 of about 2,269,213 (187)

Analysis of Autoantibodies to 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase Using Different Technologies

Journal of Immunology Research, 2014
Diagnostic tests are needed to aid in the diagnosis of necrotizing myopathies associated with statin use. This study aimed to compare different technologies for the detection of anti-HMGCR antibodies and analyze the clinical phenotype and autoantibody ...
Lucile Musset, Makoto Miyara, Olivier Benveniste, Jean-Luc Charuel, Alexander Shikhman, Olivier Boyer, Richard Fowler, Andrew Mammen, Joe Phillips, Michael Mahler   +9 more
doaj   +1 more source

Belimumab for Immune-Mediated Necrotizing Myopathy Associated With Anti-SRP Antibodies: A Case Report and Retrospective Review of Patients Treated With Anti-B-Cell Therapy in a Single Center and Literature

Frontiers in Immunology, 2021
BackgroundImmune-mediated necrotizing myopathy (IMNM) is characterized by markedly elevated creatinine kinase and histologically scattered necrotic muscle fibers and generally associated with autoantibodies against signal recognition particle (SRP) or 3 ...
Bei-Bei Cui, Yun-Ru Tian, Xin-Yue Ma, Geng Yin, Qibing Xie   +4 more
doaj   +1 more source

Autoimmune anti-HMGCR myopathy: a rare but disabling complication of statin therapy

, 2022
Presentation  An 85-year-old farmer developed disabling progressive proximal limb weakness and dysphagia after 10 years of statin therapy.  Diagnosis  Creatine kinase was elevated, and electromyography demonstrated myopathic abnormalities.
Patrick Moloney (7948142), Y Banaga (14001949), J Cryan (12709166), K O'Rourke (13685812), T Lynch (14001952), I O’Dea (13992867), J Corrigan (13396956)   +6 more
core   +3 more sources

Becker Muscular Dystrophy Accompanied by Anti-HMGCR Antibody-positive Immune-mediated Necrotizing Myopathy

Internal Medicine, 2023
Becker muscular dystrophy (BMD) is an X-linked neuromuscular disease characterized by progressive muscle weakness that currently has no cure. Immune-mediated necrotizing myopathy (IMNM) is a type of autoimmune inflammatory myopathy characterized by proximal muscle weakness that is treated with immunosuppressive therapy.
Munekane, Asami, Ohsawa, Yutaka, Okubo, Mariko, Nagai, Taiji, Nishimura, Hirotake, Nishino, Ichizo, Sunada, Yoshihide   +6 more
openaire   +3 more sources

IgG anti-apolipoprotein A-1 antibodies in patients with systemic lupus erythematosus are associated with disease activity and corticosteroid therapy: an observational study. [PDF]

, 2015
IgG anti-apolipoprotein A-1 (IgG anti-apoA-1) antibodies are present in patients with systemic lupus erythematosus (SLE) and may link inflammatory disease activity and the increased risk of developing atherosclerosis and cardiovascular disease (CVD) in ...
Davari, M, Yiannis Ioannou, Isenberg, D, Paul Bassett, Rahman, A, David Isenberg, Anisur Rahman, Maria Davari, Alber, KF, Ioannou, Y, Oliver Leach, Giles, I, Bassett, P, Karim Alber, Ian Giles, Leach, O, Sara Croca, Chambers, S, Croca, S, Sharon Chambers   +19 more
core   +1 more source

Immunotherapy reversed myopathy but not cardiomyopathy in a necrotizing autoimmune myopathy patient with positive anti-SRP and MDA-5 autoantibodies

BMC Cardiovascular Disorders, 2021
Background Necrotizing autoimmune myopathy (NAM) is pathologically characterized by myofiber necrosis and regeneration with paucity or absence of inflammatory cells in muscle biopsy.
Xue Ma, Li Xu, Yue Li, Bitao Bu
doaj   +1 more source

Anti-Saccharomyces cerevisiae antibodies in patients with inflammatory bowel disease and their first-degree relatives: Potential clinical value [PDF]

, 2002
Anti-Saccharomyces cerevisiae antibodies (ASCA) have been described as specific markers in Crohn's disease and their healthy first-degree relatives. 171 patients with Crohn's disease, their 105 first-degree relatives, 145 patients with ulcerative colitis
Török, H.-P., Hoelscher, Michael, Folwaczny, Christian, Vilsmaier, F., Herbinger, K. H., Glas, J.   +5 more
core   +1 more source

Anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase antibodies: incidence using different testing criteria, and case series

, 2022
Objectives: to estimate the incidence of anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) antibodies utilising different testing criteria, and review the clinical details of a series of patients with associated autoimmune myopathy.Methods ...
Smith, Karen A, Joseph, Vikram M K, Hajela, Vijay, Amar, Soha K, Hughes, Rod, Forster, Tamara, Rose, Emily C, Eren, Efrem, Lloyd, Mark, Edwards, Christopher J, Wheeler, Rachel D, Kiely, Patrick D W   +11 more
core   +1 more source

Host Factors Determine Anti-GM1 Response Following Oral Challenge of Chickens with Guillain-Barre Syndrome Derived Campylobacter jejuni Strain GB11 [PDF]

, 2010
Background: Anti-ganglioside antibodies with a pathogenic potential are present in C. jejuni-associated Guillain-Barre syndrome (GBS) patients and are probably induced by molecular mimicry.
Dijkstra, J.R. (Jeroen), LS Klinisch Onderzoek Wagenaar, Endtz, Hubert Ph, Ang, CW (Wim), Hubert Ph Endtz, Wagenaar, J.A., Jeurissen, Suzan H M, de Klerk, M.A., Jacobs Bart C., van Doorn, Pieter; id_orcid, Endtz Hubert Ph., Jacobs, B.C. (Bart), Endtz, Hubert, Klerk, M.A. de, Bart C Jacobs, van Doorn Pieter A., Dijkstra Jeroen R., Klerk, M.A., de, Jeurissen, P.P.T. (Patrick), Wagenaar Jaap A., de Klerk, MA, Ang, C.W., Jeurissen, SHM, Doorn, P.A., Marcel A de Klerk, Wagenaar, J.A. (Jaap), Endtz, H.P., Doorn, P.A. (Pieter) van, Doorn, P.A. van, Jacobs, B.C., Ang C. Wim, de Klerk Marcel A., Suzan H M Jeurissen, Dijkstra, JR, van Doorn, P.A., Dijkstra, J.R., Jaap A Wagenaar, Ang, C Wim, Dijkstra, Jeroen R, Wagenaar, JA, Jacobs, Bart C, Jeurissen, S.H.M., C Wim Ang, Jeroen R Dijkstra, Endtz, H.P. (Hubert), Wagenaar, Jaap A, de Klerk, Marcel A, Pieter A van Doorn, Ang, C.W. (Wim), van Doorn, Pieter A, Jeurissen Suzan H. M.   +50 more
core   +3 more sources

Anti-neurofascin antibodies [PDF]

, 2012
Neurofascin (NF) is a cell-adhesion molecule that is found at the nodes of Ranvier. The 186 kDa isoform of neurofascin (NF186) is expressed on the axon in the exposed node, and the 155 kDa isoform (NF155) is expressed on myelinating glia at the ...
Ng, King Man
core   +1 more source