Results 21 to 30 of about 1,954,791 (139)
Frontiers in Pediatrics, 2023 IntroductionAnti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) myopathy is a recently recognized pathology, but appears less common in children and the characteristics of pediatric cases remain unclear.Case reportWe report a pediatric case of ...
Keisuke Watanuki, Hiroshi Koga
doaj +1 more source
Anti-HMGCR myopathy: barriers to prompt recognition [PDF]
, 2022 Anti-HMGCR (3-hydroxy-3-methylglutaryl coenzyme A reductase) myopathy is an immune-mediated necrotising myopathy. Atypical presentations hinder its recognition and its prompt treatment.
Barp, Andrea +5 more
core +1 more source
Anti-HMGCR Immune-Mediated Necrotising Myopathy: Addressing the Remaining Issues
, 2023 The discovery of autoantibodies directed against the 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) enzyme has defined a sub-set of immune-mediated necrotising myopathy (IMNM) which is strongly associated with exposure to statin medications.
Chinoy, Hector; id_orcid, Khoo, Thomas
core +1 more source
BMC Rheumatology, 2020 Background Immune-mediated necrotising myopathy (IMNM) is characterised by severe muscle weakness and necrosis with a paucity of inflammation on muscle biopsy. Around 60% of cases are associated with antibodies to the signal recognition particle (SRP) or
Rhys Thomas +6 more
doaj +1 more source
Autoimmune anti-HMGCR myopathy: a rare but disabling complication of statin therapy
, 2022 Presentation An 85-year-old farmer developed disabling progressive proximal limb weakness and dysphagia after 10 years of statin therapy. Diagnosis Creatine kinase was elevated, and electromyography demonstrated myopathic abnormalities.
Patrick Moloney (7948142) +6 more
core +3 more sources
Anti-HMGCR Autoantibodies in Juvenile Idiopathic Inflammatory Myopathies Identify a Rare but Clinically Important Subset of Patients [PDF]
, 2017 OBJECTIVE: We aimed to establish the prevalence and clinical associations of anti-HMG-CoA-reductase (anti-HMGCR) in a large UK cohort with juvenile myositis.METHODS: There were 381 patients investigated for anti-HMGCR using ELISA.RESULTS: Anti-HMGCR ...
Wood, Mark +17 more
core +3 more sources
Six Years Follow-Up of an 11-Year-Old Girl with Anti-HMGCR Myopathy. [PDF]
J Neuromuscul Dis. Anti-HMGCR myopathy is decribed as an immune-mediated necrotizing myopathy which is characterised by subacute, progressive proximal muscle weakness and elevated creatine kinase (CK) level.
Cavusoglu D +3 more
europepmc +2 more sources
Perivascular and endomysial macrophages expressing VEGF and CXCL12 promote angiogenesis in anti-HMGCR immune-mediated necrotizing myopathy [PDF]
, 2022 Objectives: To study the phenotype of macrophage infiltrates and their role in angiogenesis in different idiopathic inflammatory myopathies (IIMs). Methods: The density and distribution of the subpopulations of macrophages subsets (M1, inducible nitric ...
Fornaro, Marco +14 more
core +1 more source
Journal of Immunology Research, 2014 Diagnostic tests are needed to aid in the diagnosis of necrotizing myopathies associated with statin use. This study aimed to compare different technologies for the detection of anti-HMGCR antibodies and analyze the clinical phenotype and autoantibody ...
Lucile Musset +9 more
doaj +1 more source
HMG-Coenzyme A Reductase as a Drug Target for the Prevention of Ankylosing Spondylitis
Frontiers in Cell and Developmental Biology, 2021 Statins are an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR). Growing evidence indicates that statins may have an anti-inflammatory effect.
Zhenyu Zhong +8 more
doaj +1 more source