Anti-HMGCR myopathy mimicking facioscapulohumeral muscular dystrophy [PDF]
Open MedicineStatin use can lead to various muscle-related issues, including benign creatine kinase (CK) elevations, myalgias, toxic myopathies, rhabdomyolysis, and immune-mediated necrotizing myositis (IMNM), which primarily affects older males.
Braun Andreas Albert +5 more
doaj +3 more sources
Arthritis Research & Therapy, 2020 Objective To describe successful therapeutic strategies in statin-induced anti-HMGCR myopathy. Methods Retrospective data from a cohort of 55 patients with statin-induced anti-HMGCR myopathy, sequentially stratified by the presence of proximal weakness ...
Alain Meyer +33 more
doaj +2 more sources
An atorvastatin‐induced positive anti‐HMGCR immune‐mediated necrotizing myopathy case [PDF]
Clinical Case ReportsKey Clinical Message Statins can commonly cause myopathy. Most of the time, stopping the culprit drug should solve the problem. However, if the drug has been discontinued but muscle weakness continues to worsen, immune‐mediated myopathy should be taken ...
Nattanicha Chaisrimaneepan +3 more
doaj +2 more sources
Complement-independent pathogenic influences of anti-HMGCR + and anti-SRP + immune-mediated necrotizing myopathy autoantibodies on engineered muscle function [PDF]
Skeletal MuscleBackground Immune-mediated necrotizing myopathy (IMNM) is a subgroup of idiopathic inflammatory myopathies associated with anti-signal recognition particle (SRP) or anti-3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) autoantibodies.
Heta Lad +9 more
doaj +2 more sources
Anti-HMGCR antibodies and asymptomatic hyperCKemia. A case report. [PDF]
Acta Myol, 2021 Anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) related myositis is a form of immune-mediated necrotizing myopathy (IMNM). Anti-HMGCR autoantibodies target HMGCR, a glycoprotein linked to the endoplasmic reticulum implied in the cholesterol ...
Torri F +4 more
europepmc +2 more sources
Rituximab use for refractory anti-HMGCR immune-mediated necrotizing myopathy: A case report [PDF]
Intractable and Rare Diseases Research, 2021 Sonia Gupta
exaly +2 more sources
The incidence of anti-HMGCR immune-mediated necrotizing myopathy: an Australian and UK retrospective multi-site cohort study. [PDF]
Rheumatology (Oxford)Objectives: Immune-mediated necrotising myopathy (IMNM) with autoantibodies targeting 3-hydroxy-3-methylglutaryl-CoA reductase (anti-HMGCR) is considered a rare complication of statin therapy.
Khoo T +14 more
europepmc +3 more sources
Diagnosis of Statin-Induced Necrotizing Myopathy: Contribution of Anti-HMGCR Antibodies
Acta Médica Portuguesa, 2022 Over the last few years, several cases of statin-induced necrotizing myopathy have been described. This myopathy is characterized by the necrosis of muscle fibers and the presence of anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (anti-HMGCR ...
Cláudia Fidalgo +3 more
doaj +1 more source
Anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) myopathy: An unusual presentation
Anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) myopathy is adistinct necrotising autoimmune myopathy associated with statin use. This does notimprove after discontinuation of the statin and usually has a progressive course that requires ...
Rashid, Amjid +3 more
core +11 more sources
Clinical Characteristics of Anti-3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Antibodies in Chinese Patients with Idiopathic Inflammatory Myopathies. [PDF]
PLoS ONE, 2015 The objective of this study was to detect the prevalence of anti-3-hydroxyl-3- methylglutaryl coenzyme A reductase (anti-HMGCR) antibodies in Chinese patients with idiopathic inflammatory myopathies (IIMs), and to analyze the clinical features of the ...
Yongpeng Ge +4 more
doaj +1 more source