A recipe for myositis : nuclear factor κB and nuclear factor of activated T-cells transcription factor pathways spiced up by cytokines [PDF]
, 2017 Nuclear factor κB (NF-κB) is a well-known pro-inflammatory transcription factor that regulates the expression of the tissue’s immune-active components, which include cytokines, chemokines and adhesion molecules.
De Paepe, Boel
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Immune myopathies with perimysial pathology: Clinical and laboratory features [PDF]
, 2018 ObjectiveImmune myopathies with perimysial pathology (IMPP) have a combination of damage to perimysial connective tissue and muscle fiber necrosis, more prominent near the perimysium.
Bucelli, Robert C, Pestronk, Alan
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Novel Presentation of Aphasia and Tremor in Immune-Mediated Necrotizing Myopathy [PDF]
Cureus, 2021 The authors present a unique case of immune-mediated necrotizing myopathy in a 60-year-old female who presented with aphasia, tremor, and progressive muscular weakness. To the best of our knowledge, the presentation of aphasia and tremor has not been previously reported in immune-mediated necrotizing myopathy. This rare presentation may mimic a variety
Gabriella Schmuter +1 more
openaire +3 more sources
Journal of Clinical Rheumatology and Immunology, 2019 We report here a statin naive lady who had refractory myositis for years. The diagnosis was revised to be anti-HMGCR related immune mediated necrotizing myopathy after repeating the muscle biopsy and checking the autoantibody.
Lucas Luk, Ho So
doaj +1 more source
Diagnosis of Statin-Induced Necrotizing Myopathy: Contribution of Anti-HMGCR Antibodies
Acta Médica Portuguesa, 2022 Over the last few years, several cases of statin-induced necrotizing myopathy have been described. This myopathy is characterized by the necrosis of muscle fibers and the presence of anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (anti-HMGCR ...
Cláudia Fidalgo +3 more
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Sarcoidosis presenting as granulomatous myositis in a 16-year-old adolescent [PDF]
, 2016 BACKGROUND: Sarcoidosis is a multi-system disease characterized by the presence of non-caseating epithelioid granulomas in affected tissues, including skeletal muscle.
Eutsler, Eric Eutsler +4 more
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Biomarkers in Inflammatory Myopathies – An Expanded Definition [PDF]
, 2019 Biomarkers as parameters of pathophysiological conditions can be of outmost relevance for inflammatory myopathies. They are particularly warranted to inform about diagnostic, prognostic, and therapeutic questions.
Benveniste, Olivier +2 more
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Inflammatory myopathies: an update for neurologists
Arquivos de Neuro-Psiquiatria, 2022 Idiopathic inflammatory myopathies (IIM) are a heterogenous group of treatable myopathies. Patients present mainly to the rheumatologist and neurologists, complaining of acute or subacute onset of proximal weakness. Extramuscular manifestations may occur,
André Macedo Serafim Silva +2 more
doaj +1 more source
Scanning for therapeutic targets within the cytokine network of idiopathic inflammatory myopathies [PDF]
, 2015 The idiopathic inflammatory myopathies (IIM) constitute a heterogeneous group of chronic disorders that include dermatomyositis (DM), polymyositis (PM), sporadic inclusion body myositis (IBM) and necrotizing autoimmune myopathy (NAM).
De Paepe, Boel, Zschüntzsch, Jana
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Myopathy with anti-HMGCR antibodies: Perimysium and myofiber pathology [PDF]
, 2015 OBJECTIVE: To analyze clinical features and myopathology changes in muscle fibers, connective tissue, and vessels in 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) antibody–associated myopathies.
Alshehri, Ali +3 more
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