Results 51 to 60 of about 2,846 (189)

Aberrant Expression of High Mobility Group Box Protein 1 in the Idiopathic Inflammatory Myopathies

Frontiers in Cell and Developmental Biology, 2020
IntroductionHigh Mobility Group Box Protein 1 (HMGB1) is a DNA-binding protein that exerts inflammatory or pro-repair effects upon translocation from the nucleus.
Jessica Day, Jessica Day, Jessica Day, Sophia Otto, Sophia Otto, Kathy Cash, Preethi Eldi, Preethi Eldi, Pravin Hissaria, Pravin Hissaria, Susanna Proudman, Susanna Proudman, Vidya Limaye, Vidya Limaye, John D. Hayball, John D. Hayball, John D. Hayball   +16 more
doaj   +1 more source

Myositis-specific autoantibodies, a cornerstone in immune-mediated necrotizing myopathy [PDF]

Autoimmunity Reviews, 2019
Over the past few years, myositis-specific autoantibodies played an increasing role in the inflammatory idiopathic myositis definition. They became the critical immunological marker for immune-mediated necrotizing myopathy diagnosis (IMNM) since the paradigm switch from histological to serological criteria. This review is focused on the key role of the
Olivier Boyer, Céline Anquetil, Olivier Benveniste, Yves Allenbach, Yves Allenbach, Nadège Wesner   +5 more
openaire   +4 more sources

Immune-mediated necrotizing myositis with hydroxy-3-methyl-glutaryl-coenzyme A reductase antibody positivity in MSA-negative and statin-naive profile

Indian Journal of Rheumatology, 2023
Statin-naïve immune-mediated necrotizing myopathy (IMNM) is a rare disease entity, the diagnosis of which is complicated in the absence of a reliable biomarker.
Kothapalli Nagamounika, Josna Joseph, R Hemanth Kumar, John Mathew   +3 more
doaj   +1 more source

Complete Recovery from COVID-19 Bilateral Pneumonia in an Immunosuppressed Man with Immune-Mediated Necrotizing Myopathy

Case Reports in Rheumatology, 2020
Immune-mediated necrotizing myopathy (IMNM) is a rare form of idiopathic immune myopathy (IIM) that requires immunotherapies, including immunosuppressive medications, if severe.
Thomas C. Bolig, Nada Abdulaziz, Elena Schiopu   +2 more
doaj   +1 more source

Alu Overexpression Leads to an Increased Double‐stranded RNA Signature in Dermatomyositis

Arthritis &Rheumatology, Accepted Article.
Objective Dermatomyositis is an autoimmune condition characterized by a high interferon signature of unknown etiology. Because coding sequences constitute <1.2% of our genomes, there is a need to explore the role of the non‐coding genome in disease pathogenesis.
Rayan Najjar, Andrew Mammen, Tomas Mustelin   +2 more
wiley   +1 more source

Mitochondrial dysfunction: Related diseases, influencing factors, and detection

Interdisciplinary Medicine, EarlyView.
Mitochondrial dysfunction is implicated in the pathogenesis of numerous diseases, including neurological disorders, cancers, and cardiovascular conditions, through mechanisms such as mitochondrial DNA mutations, dysregulation of mitochondrial network dynamics, and impaired mitophagy.
Zhaojin Li, Shiyu Li, Wanying Chen, Ziyu Zhang, Chun Pan, Peng Lei, Cheng Cheng, Junyou Zhu, Hanxiao Sun, Zhenning Dai   +9 more
wiley   +1 more source

Genital Crohn's disease in pediatrics and genetic associations

JPGN Reports, EarlyView.
Abstract Genital edema is a rare presentation of Crohn's disease (CD), also known as metastatic CD (MCD). This may precede, co‐occur with, or follow gastrointestinal symptoms and present a diagnostic challenge. We aimed to characterize the features, clinical courses, pathogenesis, and outcomes of patients with MCD to increase understanding and promote ...
Erica Chang, Caroline Chinchilla Putzeys, Edward Hoffenberg, Ashish Patel, Elizabeth Hilow, Brad Pasternak   +5 more
wiley   +1 more source

Immune Characterization of a Vietnamese Cohort With Idiopathic Inflammatory Myopathies

Muscle &Nerve, EarlyView.
ABSTRACT Introduction/Aims Idiopathic inflammatory myopathies (IIMs) are classified into five subtypes that are associated with distinct groups of myositis‐specific antibodies (MSAs). Variations in the prevalence, genetic predisposition and clinical manifestations exist in patients with IIM from different ethnic backgrounds.
Yue‐Bei Luo, Maho Nakazawa, Nham Pham Thi Minh, Léo Heinon, Inger Nennesmo, Johan Rönnelid, Ingrid E. Lundberg, Thuy Nguyen Thi Phuong, Begum Horuluoglu   +8 more
wiley   +1 more source

Immune-Mediated Necrotizing Myopathy Initially Presenting as Erythema Nodosum

Journal of Inflammation Research, 2020
Shuni Ying, Sheng Li, Shunli Tang, Qingmiao Sun, Deren Fang, Yali Li, Dingxian Zhu, Hong Fang, Jianjun Qiao Department of Dermatology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, People’s Republic of ...
Ying S, Li S, Tang S, Sun Q, Fang D, Li Y, Zhu D, Fang H, Qiao J   +8 more
doaj  

Idiopathic Inflammatory Myopathies and Malignancy Screening: A Survey of Current Practices Amongst Canadian Neurologists and Rheumatologists

Muscle &Nerve, EarlyView.
ABSTRACT Introduction/Aims Although the need for malignancy screening in idiopathic inflammatory myopathies (IIM) is generally accepted, data to guide the choice and timing of investigations are limited. Our aim was to characterize the gaps and uncertainties amongst Canadian neurologists and rheumatologists with respect to malignancy screening in IIM ...
Maria Jekielek, Rosane Nisenbaum, Ophir Vinik, Charles D. Kassardjian   +3 more
wiley   +1 more source