Results 51 to 60 of about 6,308 (185)

The Diagnosis of Signal Recognition Particle-Associated Immune-Mediated Necrotizing Myopathy Requires the Exclusion of Possible Differential Diagnose.

Acta neurologica Taiwanica
J. Finsterer
semanticscholar   +2 more sources

Statins and Immune-Mediated Necrotizing Myopathy

Clinical Management Issues, 2019
Statins are a well-recognized cause of a variety of skeletal myopathic effects, which generally resolve when discontinuing the treatment. Among autoimmune manifestations associated with statins, there is immune-mediated necrotizing myopathy (IMNM).The present article summarizes the main features of statin-related IMNM, describing diagnosis ...
openaire   +4 more sources

Intestinal and Multivisceral Transplantation: Where We Stand Today

Pediatric Transplantation, Volume 30, Issue 1, January 2026.
ABSTRACT Intestinal and multivisceral transplantation has evolved from an experimental to a life‐saving procedure for children and adults with complications of gut failure (GF). Suboptimal long‐term outcomes of transplant elicit recent advances in surgical and medical gut rehabilitation along with the introduction of glucagon‐like peptide‐2 (GLP‐2 ...
Mohamed Maklad, Mohammed Osman, Mariam Ismail, Tetsuya Tajima, Kadakkal Radhakrishnan, Masato Fujiki   +5 more
wiley   +1 more source

Drooling as a Red Flag: Insights From a Case Series in Severe Dermatomyositis With Literature Review

Clinical Case Reports, Volume 13, Issue 12, December 2025.
ABSTRACT Dermatomyositis (DM) is a rare idiopathic inflammatory disease characterized by progressive proximal muscle weakness and distinctive dermatologic manifestations. Although dysphagia is a recognized complication of oropharyngeal muscle involvement, drooling (sialorrhea) is infrequently described and may be a marker of severe disease.
Alireza Mirzamohamadi, Shokufe Sadeghi, Yalda Nilipour, Somayeh Motamed, Vahid Ardestani Rostami, Ahmadreza Jamshidi, Masoomeh Akhlaghi, Hoda Kavoosi, Majid Alikhani, Seyedeh Tahereh Faezi   +9 more
wiley   +1 more source

Spatially Resolved Profiling of Compartmentalized Muscle and Brain Inflammation

European Journal of Immunology, Volume 55, Issue 12, December 2025.
This review summarizes emerging spatially resolved multi‐omics approaches revealing organized cell–cell interactions in skeletal muscle and brain inflammation. These tools uncover radiating molecular programs and niche‐specific immunopathology that shape cellular reactivity and vulnerability.
Thorge Dobbertin, Lucas Schirmer
wiley   +1 more source

Targeted Therapy for Idiopathic Inflammatory Myopathy

Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 6, December 2025.
ABSTRACT Background Idiopathic inflammatory myopathies (IIM) are a heterogeneous group of autoimmune disorders characterized by chronic muscle inflammation and significant extramuscular involvement. A substantial proportion of patients exhibit refractory or relapsing disease despite conventional immunosuppressive therapies, necessitating the ...
Ruijie Wang, Wei Lin, Qibing Xie, Geng Yin   +3 more
wiley   +1 more source

Musculoskeletal Diseases: Mechanisms and Therapeutic Advances

MedComm, Volume 6, Issue 12, December 2025.
Musculoskeletal diseases comprise a broad spectrum of inflammatory, degenerative, and neoplastic disorders. Increasing evidence highlights the central role of immune regulation in their pathogenesis, with complex interactions among immune, bone, muscle, and stromal cells.
Xiao Ma, Eloy Yinwang, Xupeng Chai, Fangqian Wang, Zehao Chen, Shengdong Wang, Hao Zhou, Yucheng Xue, Jiangchu Lei, Fanglu Chen, Hengyuan Li, Shixin Chen, Shenzhi Zhao, Kelei Wang, Liang Chen, Junjie Gao, Zhaoming Ye, Nong Lin   +17 more
wiley   +1 more source

Immune‐mediated necrotizing myopathy with concomitant development of Kikuchi–Fujimoto disease [PDF]

, 2023
Takanori Ichikawa, Ryo Furukawa, Yasuhiro Shimojima, Yumi Hoshino, Dai Kishida, Yoshiki Sekijima   +5 more
openalex   +1 more source

The Effect of Anti‐3‐Hydroxy‐3‐Methylglutaryl‐CoA Reductase (HMGCR) Human Autoantibodies on Muscle Regeneration in Mice

Muscle &Nerve, Volume 72, Issue 6, Page 1300-1308, December 2025.
ABSTRACT Introduction/Aims Anti‐3‐hydroxy‐3‐methylglutaryl‐CoA reductase (HMGCR) autoantibodies (aAbs) are pathogenic in immune‐mediated necrotizing myopathy (IMNM), partly through complement activation. C5 inhibition did not restore muscle strength in mice or patients with overt IMNM, suggesting additional pathogenic mechanisms.
Sarah Julien, Honorine Tomasevic, Thara Jaworski, Rachid Zoubairi, Jeremie Martinet, Laurent Drouot, Olivier Boyer   +6 more
wiley   +1 more source

The Efficacy of Tocilizumab in the Treatment of Patients with Refractory Immune-Mediated Necrotizing Myopathies: An Open-Label Pilot Study [PDF]

, 2021
Sizhao Li, Wenli Li, Wei Jiang, Linrong He, Qinglin Peng, Guochun Wang, Xin Lu   +6 more
openalex   +1 more source