Results 61 to 70 of about 2,846 (189)

Seronegative patients form a distinctive subgroup of immune-mediated necrotizing myopathy [PDF]

Neurology Neuroimmunology & Neuroinflammation, 2019
To investigate the characteristics of different clinico-serologic subgroups of immune-mediated necrotizing myopathy (IMNM).We retrospectively reviewed data from medical charts of 64 patients diagnosed with IMNM between 2012 and 2017 in 3 neuromuscular referral centers in The Netherlands and 1 in Belgium.Seventeen patients had anti-3-hydroxy-3 ...
Lim, Johan, Rietveld, Anke, De Bleecker, Jan, Badrising, Umesh A, Saris, Christiaan GJ, van der Kooi, Anneke J, de Visser, Marianne   +6 more
openaire   +6 more sources

Effects of HMG CoA reductase (HMGCR) deficiency on skeletal muscle development

The FEBS Journal, EarlyView.
Three skeletal muscle diseases are linked to HMGCR, a key enzyme in cholesterol synthesis. These diseases include a muscular dystrophy associated with pathogenic variants in the HMGCR gene, statin‐associated myopathy, and autoimmune anti‐HMGCR myopathy.
Mekala Gunasekaran, Hannah R. Littel, Natalya M. Wells, Johnnie Turner, Gloriana Campos, Sree Venigalla, Elicia A. Estrella, Partha S. Ghosh, Audrey L. Daugherty, Seth A. Stafki, Louis M. Kunkel, A. Reghan Foley, Sandra Donkervoort, Carsten G. Bönnemann, Laura Toledo‐Bravo de Laguna, Andres Nascimento, Daniel Natera‐de Benito, Isabelle Draper, Christine C. Bruels, Christina A. Pacak, Peter B. Kang   +20 more
wiley   +1 more source

Anti-3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Immune-Mediated Necrotizing Myopathy following mRNA SARS-CoV-2 Vaccination

Case Reports in Neurological Medicine, 2023
The new coronavirus (COVID-19) pandemic has resulted in the unprecedented production of vaccines. In this context, the possible adverse effects remain to be identified and reported.
Marta Rodrigues de Carvalho, Myrian Mathildes Sá de Deus Rocha, Vinícius Alves Bezerra, Maciel Eduardo de Pontes, Maria Cristina del Negro, Julio Salgado Antunes, Vinícius Viana Abreu Montanaro, Rubens Nelson Morato Fernandez   +7 more
doaj   +1 more source

The Efficacy of Tocilizumab in the Treatment of Patients with Refractory Immune-Mediated Necrotizing Myopathies: An Open-Label Pilot Study

Frontiers in Pharmacology, 2021
Objective: To evaluate the efficacy of tocilizumab (TCZ) in adult patients with refractory immune-mediated necrotizing myopathies (IMNMs) and investigate possible predictive biomarkers of the response to treatment with TCZ.Methods: Patients with ...
Sizhao Li, Wenli Li, Wei Jiang, Linrong He, Qinglin Peng, Guochun Wang, Xin Lu   +6 more
doaj   +1 more source

The Role of Repeat Skeletal Muscle Biopsy: Indications, Yield and Outcomes

Muscle &Nerve, Volume 72, Issue 2, Page 217-223, August 2025.
ABSTRACT Introduction/Aims Muscle biopsy performed to investigate weakness and/or pain may be nondiagnostic and prompt repeat biopsy. We determined the indications and yield of rebiopsy. Methods Patients who underwent > 1 muscle biopsy (South Australia, 2000–2023) were identified.
Thomas Khoo, Sarah Saxon, Barbara Koszyca, Bernice Gutschmidt, Vidya Limaye   +4 more
wiley   +1 more source

Deep venous thrombosis in an individual with statin-exposed anti-SRP myopathy: case report and review of literature

Thrombosis Journal, 2021
Background Immune-mediated necrotizing myopathy (IMNM) is characterized by proximal muscle weakness, elvated serum muscle enzyme levels, myopathic electromyography findings, and necrotic muscle fiber with few inflammatory cell infiltration in muscle ...
Jiali Li, Mingming Yan, Jiao Qin, Lingyan He, Cao Dai, Rui Wen   +5 more
doaj   +1 more source

Isolated Oropharyngeal Dysphagia as the Initial Presentation of Anti-SRP Immune-Mediated Necrotizing Myopathy

Journal of Health Science and Medical Research (JHSMR), 2021
A 51-year-old male initially presented with a progressive course of isolated oropharyngeal dysphagia prior to the clinical course of painful symmetrical proximal muscle weakness without sensory deficit which rendered him to wheelchairbound status within ...
Pat Korathanakhun, Thanyalak Amornpojnimman   +1 more
doaj   +1 more source

Immune Checkpoint Inhibitor‐Related Dysautonomia in Merkel Cell Carcinoma: A Case Report

Cancer Reports, Volume 8, Issue 7, July 2025.
ABSTRACT Background Immune checkpoint inhibitors (ICIs) are monoclonal antibodies that block inhibitory pathways that cancer cells exploit to suppress T‐cell activation. Although immune‐related adverse events (irAEs) linked to ICI therapy are well documented and encompass dermatologic, endocrine, gastrointestinal, hepatic, and neurologic systems, ICI ...
Nidhi Kuchimanchi, Sai Gajula, Elizabeth M. Gaughan, Russell G. Witt   +3 more
wiley   +1 more source

Anti-Signal Recognition Particle Myopathy in a Geriatric Patient

European Journal of Case Reports in Internal Medicine, 2015
Anti-signal recognition particle (SRP) myopathy is a rare idiopathic inflammatory myositis that usually affects middle-age women, and is characterized by rapidly progressive proximal and symmetrical muscle weakness, elevated creatine kinase levels ...
Diana Marques Ferreira, Patrícia Afonso Mendes, António Aragão, Manuel Teixeira Veríssimo, Armando Carvalho   +4 more
doaj   +1 more source

Anti-SRP immune-mediated necrotizing myopathy: A critical review of current concepts

Frontiers in Immunology, 2022
Purpose of reviewThis review aims to describe clinical and histological features, treatment, and prognosis in patients with anti-signal recognition particle (SRP) autoantibodies positive immune-mediated necrotizing myopathy (SRP-IMNM) based on previous ...
Xue Ma, Bi-Tao Bu
doaj   +1 more source