Results 71 to 80 of about 2,846 (189)

Incidence and Immunopathology of Myositis in Rectal Cancer Patients Treated With Neoadjuvant Immune Checkpoint Inhibitors and Chemoradiotherapy: Findings From the CHINOREC Trial

MedComm, Volume 6, Issue 7, July 2025.
ICI‐induced myositis occurred at a higher‐than‐expected rate (12%) in neoadjuvant‐treated rectal cancer patients receiving CRT+ICI. Elevated cTnT, but not cTnI, differentiated skeletal from cardiac involvement. Immunopathology showed a predominant CD8+ T cell infiltrate, highlighting a T cell‐mediated mechanism that necessitates early detection and ...
Rebecca Zirnbauer, Simon Hametner, Jutta Bergler‐Klein, Irene Kuehrer, Askin Kulu, Daphni Ammon, Julijan Kabiljo, Anton Stift, Rainer Schmid, Leonhard Müllauer, Clemens Bittermann, Friedrich Laengle, Klaus Machold, Stephan Blüml, Michael Bergmann, Johannes Laengle   +15 more
wiley   +1 more source

Statin-Associated Autoimmune Myopathy: Current Perspectives

Therapeutics and Clinical Risk Management, 2020
Eleni Tiniakou Johns Hopkins University School of Medicine, Department of Medicine, Division of Rheumatology, Baltimore, MD, USACorrespondence: Eleni TiniakouJohns Hopkins University School of Medicine, 5200 Eastern Avenue, Mason Lord, Center Tower ...
Tiniakou E
doaj  

Immune Mediated Necrotizing Myopathy: a Cause of Isolated Myopathy of Neck Extensor Muscle [PDF]

Clinical Medicine & Research, 2016
Immune mediated necrotizing myopathy (IMNM) is a unique form of myositis that is characterized by distinct muscle biopsy features including abundant myofiber necrosis, degeneration, and regeneration with only minimal, if any, inflammation on muscle biopsy.
Rafael Medina-Flores, Ralph Yachoui, Charles V Kenney, Rahul Sehgal   +3 more
openaire   +3 more sources

Efficacy and Safety of Subcutaneous Abatacept Plus Standard Treatment for Active Idiopathic Inflammatory Myopathy: Phase 3 Randomized Controlled Trial

Arthritis &Rheumatology, Volume 77, Issue 6, Page 765-776, June 2025.
Objective Our objective was to evaluate the efficacy and safety of subcutaneous (SC) abatacept and standard of care (SOC) for the treatment of idiopathic inflammatory myopathy (IIM) over 52 weeks. Methods In this randomized, double‐blind, placebo‐controlled phase III trial, patients with treatment‐refractory IIM received SC abatacept (at 125 mg weekly)
Rohit Aggarwal, Ingrid E. Lundberg, Yeong‐Wook Song, Aziz Shaibani, Victoria P. Werth, Michael A. Maldonado   +5 more
wiley   +1 more source

Diabetic myonecrosis complicated by emphysematous pyomyositis and abscess caused by Escherichia coli: a case report

Journal of Medical Case Reports
Background Necrotizing myopathies and muscle necrosis can be caused by immune-mediated mechanisms, drugs, ischemia, and infections, and differential diagnosis may be challenging. Case presentation We describe a case of diabetic myonecrosis complicated by
Anne M. Kerola, Kari K. Eklund, Heikki Valleala, Olli Tynninen, Jaakko Helve, Ville Haapamäki, Mari Eriksson   +6 more
doaj   +1 more source

Anti-HMG-CoA reductase myopathy, an undesirable evolution of statin induced myopathy: a case report

Journal of Community Hospital Internal Medicine Perspectives, 2019
Statins are commonly used lipid lowering agents which play a pivotal role in reducing cardiovascular morbidity and mortality. Often well tolerated, these HMG-CoA reductase (HMGCR) inhibitors can sometimes cause severe muscle weakness and elevated ...
Sunita Upreti, Beenish Fayyaz, Ramchandran P. Bongu   +2 more
doaj   +1 more source

Ageing Signatures and Disturbed Muscle Regeneration in Muscle Proteome of Inclusion Body Myositis

Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 3, June 2025.
ABSTRACT Background Inclusion body myositis (IBM) is the most common acquired myopathy in adults over the age of 50 years, characterised by inflammatory and degenerative features that lead to progressive muscle weakness and physical disability for lack of effective therapies.
Geert M. de Vries, Bob Asselbergh, Alice Monticelli, Peter De Jonghe, Stuart Maudsley, Peter Y. K. Van Den Bergh, Anne Bigot, Jan L. De Bleecker, Biljana Ermanoska, Willem De Ridder, Jonathan Baets   +10 more
wiley   +1 more source

Polymyositis associated with dyspnoea and interstitial lung disease in a dog (Canis familiaris)

Veterinary Record Case Reports, Volume 13, Issue 2, June 2025.
Abstract A 5‐year‐old, female, spayed coonhound was evaluated for progressive dyspnoea, weakness and weight loss. The patient had increased inspiratory and expiratory respiratory effort and generalised skeletal muscle atrophy. Thoracic radiographs and computed tomography revealed interstitial lung disease. Magnetic resonance imaging revealed multifocal
Kaycee Daentl, Victoria Umana, Stefanie DeMonaco   +2 more
wiley   +1 more source

Initial seronegative immune-mediated necrotising myopathy with subsequent anti-HMGCR antibody development and response to rituximab: case report

BMC Rheumatology, 2020
Background Immune-mediated necrotising myopathy (IMNM) is characterised by severe muscle weakness and necrosis with a paucity of inflammation on muscle biopsy. Around 60% of cases are associated with antibodies to the signal recognition particle (SRP) or
Rhys Thomas, Su-Ann Yeoh, Rupert Berkeley, Andrew Woods, Mike Stevens, Silvia Marino, Aleksandar Radunovic   +6 more
doaj   +1 more source

Belimumab for Immune-Mediated Necrotizing Myopathy Associated With Anti-SRP Antibodies: A Case Report and Retrospective Review of Patients Treated With Anti-B-Cell Therapy in a Single Center and Literature [PDF]

, 2021
Beibei Cui, Yunru Tian, Xinyue Ma, Geng Yin, Qibing Xie   +4 more
openalex   +1 more source