Results 11 to 20 of about 614,807 (307)

Barriers to immune cell infiltration in tumors

Journal for ImmunoTherapy of Cancer, 2023
Increased immune cell infiltration into tumors is associated with improved patient survival and predicts response to immune therapies. Thus, identification of factors that determine the extent of immune infiltration is crucial, so that methods to ...
Craig L Slingluff, Marit M Melssen, Natasha D Sheybani, Katie M Leick   +3 more
doaj   +3 more sources

SLC43A2-mediated immune cell infiltration: a potential therapeutic target in acute myeloid leukemia [PDF]

Frontiers in Immunology
BackgroundTumor cells compete with T cells for methionine by overexpressing SLC43A2 (solute carrier family 43 member 2), leading to T cell exhaustion. However, the correlation between SLC43A2 and immune infiltration or malignant features in acute myeloid
Mengnan Li, Tao Zhang, Bing Wang, Jile Liu, Mohan Zhao, Yanyu Jiang, Yu Zhang, Mingfeng Zhao   +7 more
doaj   +2 more sources

DFNA5 regulates immune cells infiltration and exhaustion [PDF]

Cancer Cell International, 2022
Abstract Background DFNA5 (GSDME) belongs to Gasdermin familily that is involved in a variety of cancers and triggers cell pyroptosis after chemical treatment. However, the relationship in DFNA5 between prognosis and immune cells in diverse cancers has been receiving little attention.
Jian Hu, Wenceng Pei, Minren Jiang, Ying Huang, Fuyun Dong, Zhenyou Jiang, Ying Xu, Zihuang Li   +7 more
openaire   +3 more sources

Immune infiltrating cells in duodenal cancers [PDF]

Journal of Translational Medicine, 2020
Abstract Background Duodenal adenocarcinoma (DA) is a rare yet aggressive malignancy, with increasing incidence in the last decades. Its low frequency has hampered a thorough understanding of the pathogenesis of the disease and of its biology, limiting the identification of tailored therapeutic options.
Donisi, G., Capretti, G., Cortese, N., Rigamonti, A., Gavazzi, F., Nappo, G., Pulvirenti A, Sollai, M., Spaggiari, P., Zerbi, A., Marchesi, F   +20 more
openaire   +3 more sources

Integrated single cell and bulk sequencing analysis identifies tumor reactive CXCR6+ CD8 T cells as a predictor of immune infiltration and immunotherapy outcomes in hepatocellular carcinoma

Frontiers in Oncology, 2023
BackgroundVarious immune cell types in the tumor microenvironment (TME) of hepatocellular carcinoma (HCC) have been identified as important parameters associated with prognosis and responsiveness to immunotherapy.
Xiaogang Li, Xiaogang Li, Zheng Gao, Zheng Gao, Jiafeng Chen, Jiafeng Chen, Shanru Feng, Shanru Feng, Xuanming Luo, Yinghong Shi, Yinghong Shi, Zheng Tang, Zheng Tang, Weiren Liu, Weiren Liu, Xin Zhang, Xin Zhang, Ao Huang, Ao Huang, Qiang Gao, Qiang Gao, Aiwu Ke, Aiwu Ke, Jian Zhou, Jian Zhou, Jian Zhou, Jia Fan, Jia Fan, Xiutao Fu, Xiutao Fu, Zhenbin Ding, Zhenbin Ding, Zhenbin Ding   +32 more
doaj   +1 more source

Macrophage depletion disrupts immune balance and energy homeostasis. [PDF]

, 2014
Increased macrophage infiltration in tissues including white adipose tissue and skeletal muscle has been recognized as a pro-inflammatory factor that impairs insulin sensitivity in obesity.
Feng, Gen-Sheng, Kinney, Brice, Lee, Bonggi, Qiao, Liping, Shao, Jianhua   +4 more
core   +12 more sources

Development of an Immune-Related Gene Signature for Prognosis in Melanoma

Frontiers in Oncology, 2021
Melanoma remains a potentially deadly malignant tumor. The incidence of melanoma continues to rise. Immunotherapy has become a new treatment method and is widely used in a variety of tumors. Original melanoma data were downloaded from TCGA.
Jia-An Zhang, Xu-Yue Zhou, Dan Huang, Chao Luan, Heng Gu, Mei Ju, Kun Chen   +6 more
doaj   +1 more source

Cdx2 regulates immune cell infiltration in the intestine [PDF]

Scientific Reports, 2021
AbstractThe intestinal epithelium is a unique tissue, serving both as a barrier against pathogens and to conduct the end digestion and adsorption of nutrients. As regards the former, the intestinal epithelium contains a diverse repertoire of immune cells, including a variety of resident lymphocytes, macrophages and dendritic cells.
Simon Chewchuk, Sanzida Jahan, David Lohnes   +2 more
openaire   +3 more sources

Combined PD-1/PD-L1 and tumor-infiltrating immune cells redefined a unique molecular subtype of high-grade serous ovarian carcinoma

BMC Genomics, 2022
Background High-grade serous ovarian carcinoma is highly heterogeneous, and although many studies have been conducted to identify high-grade serous ovarian carcinoma molecular subtypes that are sensitive to immunotherapy, no precise molecular subtype has
Ping Liu, Ruoxu Chen, Xudong Zhang, Ruiting Fu, Lin Tao, Wei Jia   +5 more
doaj   +1 more source

Immune infiltration in renal cell carcinoma [PDF]

Cancer Science, 2019
Immune infiltration of tumors is closely associated with clinical outcome in renal cell carcinoma (RCC). Tumor‐infiltrating immune cells (TIICs) regulate cancer progression and are appealing therapeutic targets. The purpose of this study was to determine the composition of TIICs in RCC and further reveal the independent prognostic values of TIICs ...
Shichao Zhang, Erdong Zhang, Jinhua Long, Zuquan Hu, Jian Peng, Lina Liu, Fuzhou Tang, Long Li, Yan Ouyang, Zhu Zeng   +9 more
openaire   +2 more sources