Results 261 to 270 of about 6,100,412 (305)

WT1‐Targeted Oral Bifidobacterium longum Vaccine Enhances Checkpoint Blockade Efficacy in Pancreatic Cancer

Advanced Science, EarlyView.
Oral WT1‐targeted Bifidobacterium longum vaccine promotes WT1‐associated cellular immunity and enhances anti‐PD‐1/anti‐CTLA‐4 efficacy in pancreatic cancer. ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) remains largely unresponsive to immune checkpoint inhibitors (ICI) due to its profoundly immunosuppressive tumor microenvironment.
Taiki Yamazaki, Aori Minami, Misako Hirota, Mirei Hirano, Ryota Sato, Atsuki Honma, Hideto Ueki, Toshiro Shirakawa   +7 more
wiley   +1 more source

RBM15 is a novel prognostic biomarker and correlates with immune cell infiltration in lung adenocarcinoma. [PDF]

J Cardiothorac Surg
Ma M, Wang W, Li L, Wang X, Huang Q, Zhou C, Ye L.   +6 more
europepmc   +1 more source

Molecular Editing Reveals a Bilobalide Chemotype that Attenuates Prolyl Endopeptidase (PREP)‐Linked Neuroinflammation

Advanced Science, EarlyView.
Molecular editing of bilobalide uncovers BB56, a PREP‐engaging chemotype with enhanced anti‐inflammatory activity in microglia. Integrated CETSA‐MS, SAR, and pathway analyses link BB56 to attenuation of p38 MAPK/NF‐κB and NLRP3‐associated inflammatory signaling, highlighting bilobalide editing as a strategy for developing neuroinflammation‐modulating ...
Chanin Sillapachaiyaporn, Wenjing Wang, Yao Qin, Lili Yan, Stephan Scheeff, Xu He, Qiong Wu, Yue Lin, Jinsai Shang, Xin Ye, Jing Liu, Kailei Sun, Chun Wai Yeung, Junzhe Huang, Zhenghui Chen, Xiaodong Liu, Yiqun Geng, Shannon Wing Ngor Au, Bonaventure Y. Ip, Ho Ko, Billy Wai‐Lung Ng   +20 more
wiley   +1 more source

Analysis of Immune Cell Infiltration Distribution and Prognostic Value in Obstructive Colorectal Cancer. [PDF]

Biomedicines
Xue Y, Jiang Z, Gu J, Deng S, Cai K, Wu K.   +5 more
europepmc   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Immune Cell Infiltration and Kynurenine Pathway Activation Define Early Injury and Progression in Diabetic Nephropathy. [PDF]

Int J Biol Sci
Tsai YC, Dai CY, Tsai MJ, Hwang SJ, Yu PS, Hung WW, Pan SF, Wu LY, Tsai PH, Tsai HP, Chang WA, Hsu YL.   +11 more
europepmc   +1 more source

Research progress on the mechanisms of cGAS-STING signaling in immune cell infiltration associated with vascular remodeling. [PDF]

J Transl Med
Zhang X, Cheng L, Ma X, Ma K, Xie J, Gui W, Chen J, Liu K, Ma R.   +8 more
europepmc   +1 more source

Systematic analysis of bacterial lipopolysaccharide-related genes and immune cell infiltration characteristics in pediatric septic shock using integrated bioinformatics and machine learning approaches. [PDF]

Front Bioinform
Qiao J, Zou L, Zhao J, Cui C, Huang X, Fan Y.   +5 more
europepmc   +1 more source

Comprehensive profiling of immune cell infiltration and biomarker identification in intervertebral disc degeneration. [PDF]

J Orthop Surg Res
Wang Y, Hu B, Tian L, Li G, Xu B.
europepmc   +1 more source

Neuronal precursor cell persistence in ganglioglioma is associated with extracellular matrix remodeling and immune cell infiltration. [PDF]

Neurooncol Adv
Kueckelhaus J, Hoffmann L, Menstell JA, Zimmer DN, Kada-Benotmane J, Zhang J, Beck J, Schnell O, Sankowski R, Sievers P, Sahm F, Delev D, Heiland DH.   +12 more
europepmc   +1 more source