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Protocol for analyzing immune cell infiltration in 3D pancreatic heterotypic spheroids composed of tumor cells and cancer-associated fibroblasts. [PDF]

STAR Protoc
Thomas B, Nadia VV, Clara F, Nelly P, Nathalie B, Celine G, Christel L, Laurent G.   +7 more
europepmc   +1 more source

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A Study on Immune Cell Infiltration in Lung Adenocarcinoma

Combinatorial Chemistry & High Throughput Screening, 2022
Background: As a vital part of the tumor environment, immune cells affect the progression of tumors, and their composition and role vary in different types of tumors and influence prognosis. These immune cells have the potential to be beneficially targeted for immunotherapy, or, conversely, they may react negatively, even leading to drug resistance ...
Hongwen Zhao, Bingqing Sun
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CCL21-induced immune cell infiltration

International Immunopharmacology, 2007
Cellular immune responses can be initiated via peptide presentation by specialized antigen presenting cells, dendritic cells (DCs), which stimulate naïve T cells. The trafficking of DCs and T cells is regulated by chemokines such as CCL21. CCL21 is normally expressed in the lymphoid organs and coordinates the interactions between DCs and T cells ...
Abdelkader E, Ashour, Heth R, Turnquist, Rakesh K, Singh, James E, Talmadge, Joyce C, Solheim   +4 more
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Immune Cell Infiltration in Feline Meningioma

Journal of Comparative Pathology, 2017
Meningioma is the most common primary brain tumour in the cat. Although most of these tumours are considered to be benign based on histological characteristics, little is known regarding microenvironmental changes associated with the tumour. The characterization of the immune-cell infiltrate in human and canine meningiomas has been described; however ...
R, McBride, E A, Sloma, H N, Erb, A D, Miller   +3 more
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Tumor infiltrating immune cells in gliomas and meningiomas

Brain, Behavior, and Immunity, 2016
Tumor-infiltrating immune cells are part of a complex microenvironment that promotes and/or regulates tumor development and growth. Depending on the type of cells and their functional interactions, immune cells may play a key role in suppressing the tumor or in providing support for tumor growth, with relevant effects on patient behavior.
Domingues, Patrícia, González-Tablas, María, Otero, Álvaro, Pascual, Daniel, Miranda, David, Ruiz, Laura, Sousa, Pablo, Ciudad, Juana, Gonçalves, Jesús María, Lopes, María Celeste, Orfao de Matos Correia e Vale, José Alberto, Tabernero, María Dolores   +11 more
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Immunohistochemical evaluation of immune cell infiltration in canine gliomas

Veterinary Pathology, 2021
Evasion of the immune response is an integral part of the pathogenesis of glioma. In humans, important mechanisms of immune evasion include recruitment of regulatory T cells (Tregs) and polarization of macrophages toward an M2 phenotype. Canine glioma has a robust immune cell infiltrate that has not been extensively characterized.
Gregory A. Krane, Carly A. O’Dea, David E. Malarkey, Andrew D. Miller, C. Ryan Miller, Debra A. Tokarz, Heather L. Jensen, Kyathanahalli S. Janardhan, Keith R. Shockley, Norris Flagler, Brittani A. Rainess, Christopher L. Mariani   +11 more
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Decidual Immune Cell Infiltrate in Hydatidiform Mole

Cancer Investigation, 2009
Hydatidiform mole is a gestational trophoblastic disease characterized by proliferation of the pregnancy-associated trophoblastic tissue. Complete hydatidiform mole is an entirely paternally derived lesion, and therefore, represents complete intrauterine allografts that can induce an altered maternal immune response Hypothesis: Here, we hypothesize ...
Mahmoud R, Hussein, Ahmad Rezk, Abd-Elwahed, Eman Sayed, Abodeif, Saad Rezk, Abdulwahed   +3 more
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Characterization of the immune cell infiltration landscape in lung adenocarcinoma

Archives of Biochemistry and Biophysics, 2022
Immune checkpoint inhibitors (ICIs) have played an important role in the treatment of lung adenocarcinoma (LUAD). However, their effectiveness is limited, and many patients exhibit a weak response. In this study, we propose a new and more effective immunophenotyping method for evaluating the prognosis and tumor microenvironment (TME) cellular ...
Hai-Bin, Ou, Yan, Wei, Yu, Liu, Fu-Xiang, Zhou, Yun-Feng, Zhou   +4 more
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Characterization of endometriosis-associated immune cell infiltrates (EMaICI)

Archives of Gynecology and Obstetrics, 2016
To identify and characterize endometriosis-associated immune cell infiltrates (EMaICI). Furthermore, to define occurrence and size of EMaICI in various types of endometriosis.Immune cells were characterized in samples of 60 premenopausal women with histological proven endometriosis. Therefore, immunohistochemical staining with monoclonal antibodies for
Claudia, Scheerer, Petia, Bauer, Vito, Chiantera, Jalid, Sehouli, Andreas, Kaufmann, Sylvia, Mechsner   +5 more
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Characterization of Immune Cell Infiltration Into Canine Intracranial Meningiomas

Veterinary Pathology, 2011
Meningiomas are the most common intracranial tumors in dogs. A variety of inflammatory cells have been shown to invade these tumors in people, but little is known about interactions between the immune system and naturally occurring brain tumors in dogs.
L B, Boozer, T W, Davis, L B, Borst, K M, Zseltvay, N J, Olby, C L, Mariani   +5 more
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