Results 31 to 40 of about 227,121 (132)

Reprogramming the tumor microenvironment to overcome immunotherapy resistance in pancreatic cancer

Frontiers in Immunology
BackgroundPancreatic ductal adenocarcinoma (PDAC) exhibits profound resistance to immunotherapy due to its highly immunosuppressive tumor microenvironment (TME).ObjectiveThis review aims to elucidate the key mechanisms of TME-mediated immune evasion in ...
Xianfeng Hui, Xianfeng Hui, Xianfeng Hui, Xiaowei Tian, Shihuan Ding, Shihuan Ding, Shihuan Ding, Aiping Sun, Tiesuo Zhao, Tiesuo Zhao, Hui Wang, Hui Wang   +11 more
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Immune Checkpoint Molecules in Reproductive Immunology

Frontiers in Immunology, 2019
Immune checkpoint molecules, like CTLA-4, TIM-3, PD-1, are negative regulators of immune responses to avoid immune injury. Checkpoint regulators are thought to actively participate in the immune defense of infections, prevention of autoimmunity ...
Eva Miko, Eva Miko, Matyas Meggyes, Matyas Meggyes, Katalin Doba, Aliz Barakonyi, Aliz Barakonyi, Laszlo Szereday, Laszlo Szereday   +8 more
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Advances and prospects of mucosal vaccination in the prevention and control of avian influenza

Frontiers in Immunology
Avian influenza virus (AIV) poses a persistent threat to global poultry production and public health. Long-term immunization programs have established a foundational immune barrier, significantly mitigating the risk of highly pathogenic avian influenza ...
Xianfeng Hui, Xianfeng Hui, Xiaowei Tian, Xiaowei Tian, Shihuan Ding, Shihuan Ding, Ge Gao, Shuoxiang Gao, Shuoxiang Gao, Aiping Sun, Aiping Sun, Tiesuo Zhao, Tiesuo Zhao, Hui Wang   +13 more
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CBX4 facilitates EV71 replication by SUMOylation and stabilizing 3D polymerase

Frontiers in Microbiology
Enterovirus 71 (EV71) is a primary etiological agent of hand-foot-mouth disease (HFMD) in children under 5 years of age and can cause severe neurological disorders even death.
Rui Su, Yifan Niu, Aiping Sun, Aiping Sun, Tiesuo Zhao, Tiesuo Zhao, Hui Wang   +6 more
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Key questions about the checkpoint blockade-are microRNAs an answer?

Cancer Biology & Medicine, 2018
The introduction of immune-checkpoint blockade in the cancer therapy led to a paradigm change of the management of late stage cancers. There are already multiple FDA approved checkpoint inhibitors and many other agents are undergoing phase 2 and early ...
Mihnea Dragomir, Baoqing Chen, Xiao Fu, George A. Calin   +3 more
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MiR-30a-5p activates the AKT signalling pathway by targeting PHTF2 to inhibit migration and EMT of gastric cancer

Scientific Reports
MicroRNAs (miRNAs) play a very important role in the development of gastric cancer (GC). MiR-30a-5p Participates in the formation and progression of various cancers. However, the role and clinical value of miR-30a-5p in GC remain unclear.
Fei Tu, Fengyuan He, Zhiyuan Li, Yiqing Jia, Lingzhu Wang, Tiesuo Zhao, Sheng Guo, Yan Jin, Zhijun Yang   +8 more
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The role of Clostridium butyricum and its metabolites in modulating gut mucosal immunity: implications for viral infections and inflammatory diseases

Frontiers in Immunology
With global viral emergence and increasing antiviral resistance, there is an urgent need for innovative immunomodulatory strategies. Gut microbiota modulation has gained attention as a promising therapeutic approach. Clostridium butyricum (C.
Shaoju Qian, Shaoju Qian, Shaoju Qian, Siyu Li, Keyan Ye, Shuao Lu, Xiaoming Sha, Danqiong Zhang, Zhishan Xu, Zhishan Xu, Zhishan Xu, Xiangfeng Song, Xiangfeng Song, Xiangfeng Song, Ruixue Li   +14 more
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Pneumonitis and multiple pneumonial infections under combined immune‐checkpoint inhibition

JEADV Clinical Practice, 2023
The introduction of immune checkpoint inhibitors and targeted therapies has revolutionized melanoma treatment. The downside are immune‐mediated adverse events which are frequent and require close patient management.
Kristine E. Mayer, Thomas Gan, Jochen Gaa, Tilo Biedermann, Christian Posch   +4 more
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Regulation of Intrinsic Functions of PD-L1 by Post-Translational Modification in Tumors

Frontiers in Oncology, 2022
Tumor cells are eliminated by the immune system, including T lymphocytes and natural killer cells; however, many types of tumor cells acquire the immune tolerance by inhibiting T-cell activation and functions via immune checkpoint molecules ...
Naoe Taira Nihira, Naoe Taira Nihira, Yoshio Miki   +2 more
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Harnessing the immune system by targeting immune checkpoints: Providing new hope for Oncotherapy

Frontiers in Immunology, 2022
With the goal of harnessing the host’s immune system to provide long-lasting remission and cures for various cancers, the advent of immunotherapy revolutionized the cancer therapy field.
Lu Yu, Minghan Sun, Qi Zhang, Qiao Zhou, Qiao Zhou, Qiao Zhou, Yi Wang   +6 more
doaj   +1 more source