A Highlight of the Mechanisms of Immune Checkpoint Blocker Resistance [PDF]
Frontiers in Cell and Developmental Biology, 2020 In recent years, as our understanding of tumor immunology is continuously improved, immunotherapy has come to the center stage of cancer therapy and is deemed as the most promising approach for cancer control.
Qian Huang +4 more
doaj +3 more sources
Emerging biomarkers for the combination of radiotherapy and immune checkpoint blockers [PDF]
Seminars in Cancer Biology, 2018 Over the past few years, multiple immune checkpoint blockers (ICBs) have achieved unprecedented clinical success and have been approved by regulatory agencies for the treatment of an increasing number of malignancies. However, only a limited fraction of patients responds to ICBs employed as a standalone intervention, calling for the development of ...
Claire Vanpouille-Box +2 more
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Immune checkpoint blockers in solid organ transplant recipients and cancer: the INNOVATED cohort [PDF]
ESMO OpenPatients with solid organ transplant (SOT) and solid tumors are usually excluded from clinical trials testing immune checkpoint blockers (ICB). As transplant rates are increasing, we aimed to evaluate ICB outcomes in this population, with a special focus on lung cancer.We conducted a multicenter retrospective cohort study collecting real data of ICB ...
E Auclin, F Aboubakar, N Blais
exaly +7 more sources
Targeting TMEM176B Enhances Antitumor Immunity and Augments the Efficacy of Immune Checkpoint Blockers by Unleashing Inflammasome Activation [PDF]
Cancer Cell, 2019 Although immune checkpoint blockers have yielded significant clinical benefits in patients with different malignancies, the efficacy of these therapies is still limited. Here, we show that disruption of transmembrane protein 176B (TMEM176B) contributes to CD8+ T cell-mediated tumor growth inhibition by unleashing inflammasome activation.
Maria Cristina Cuturi +2 more
exaly +9 more sources
Alleviation of exhaustion-induced immunosuppression and sepsis by immune checkpoint blockers sequentially administered with antibiotics—analysis of a new mathematical model [PDF]
Intensive Care Medicine Experimental, 2019 Background Sepsis-associated immune dysregulation, involving hyper-inflammation and immunosuppression, is common in intensive care patients, often leading to multiple organ dysfunction and death.
Avi Gillis +5 more
doaj +2 more sources
Targeting T-Cells for Cancer Treatment: Current Clinical Strategies and Challenges [PDF]
BiomedicinesModulation of immune response to target tumor cells has been shown to be a successful strategy for cancer treatment. Over the past years immunotherapy has been integrated into cancer treatment and PD-1 blockers have become the backbone of treatment ...
Anand Rotte +2 more
doaj +2 more sources
Evaluation safety and efficacy of immune checkpoint blockers (ICB) and radiotherapy combination versus ICB in non‐small cell lung cancer patients with recurrence or metastasis: A systematic review and meta‐analysis [PDF]
Cancer Medicine, 2023 Buhai Wang
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Cross-Reactivity and Functionality of Approved Human Immune Checkpoint Blockers in Dogs. [PDF]
Cancers (Basel), 2021 Background: Rodent cancer models have limitations in predicting efficacy, tolerability and accompanying biomarkers of ICIs in humans. Companion dogs suffering from neoplastic diseases have gained attention as a highly relevant translational disease model.
Pantelyushin S +9 more
europepmc +5 more sources
Role of immune checkpoint blockers in patients with EGFR mutation. [PDF]
Transl Lung Cancer Res, 2018 Ward J, Morgensztern D.
europepmc +4 more sources
Toward Precision Radiotherapy for Use with Immune Checkpoint Blockers. [PDF]
Clin Cancer Res, 2018 Abstract The first evidence that radiotherapy enhances the efficacy of immune checkpoint blockers (ICB) was obtained a dozen years ago in a mouse model of metastatic carcinoma refractory to anti–CTLA-4 treatment. At the time, ICBs had just entered clinical testing, an endeavor that culminated in 2011 with the approval of the first anti ...
Vanpouille-Box C +2 more
europepmc +4 more sources