Results 281 to 290 of about 1,989,151 (330)

Immune checkpoints and pancreatic beta cell dysfunction in HIV. [PDF]

AIDS
Pryke LA, Liu Z, Khaitan AK, Sims EK, Gupta SK.   +4 more
europepmc   +1 more source

PD-1 and LAG-3 were optimal combination of immune checkpoints for predicting poor clinical outcomes of patients with ovarian cancer. [PDF]

Front Immunol
Wu Y, Chen C, Cui Y, Zou R, Yang Y, Sun F, Du Y, Wang P.   +7 more
europepmc   +1 more source

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Immune Checkpoint Blockade

Hematology/Oncology Clinics of North America, 2014
Since the development and approval of Ipilimumab, the first immune checkpoint inhibitor licensed for the treatment of metastatic melanoma, clinicians have gained a better understanding of the mode of action, management of toxicities, and assessment of response to this class of drugs.
Jarushka, Naidoo, David B, Page, Jedd D, Wolchok   +2 more
openaire   +2 more sources

Epigenetics Meets Immune Checkpoints

Seminars in Oncology, 2015
Epigenetic alterations play a pivotal role in cancer development and progression. Pharmacologic reversion of such alterations is feasible, and second generation "epigenetic drugs" are in development and have been demonstrated to possess significant immunomodulatory properties.
Covre A., Coral S., Di Giacomo A. M., Taverna P., Azab M., Maio M.   +5 more
openaire   +3 more sources

Immune Checkpoint Inhibitor Toxicity

Current Oncology Reports, 2018
Immune checkpoint inhibitors have revolutionised the treatment of multiple malignancies and have a growing list of indications. As our familiarity with these agents grows, so does our understanding of their unique spectrum of toxicities. Here, we will review the literature regarding the toxicities of checkpoint inhibitors and address challenges ...
David J, Palmieri, Matteo S, Carlino
openaire   +2 more sources

Microglial immune checkpoint mechanisms

Nature Neuroscience, 2018
Microglia differentiate from progenitors that infiltrate the nascent CNS during early embryonic development. They then remain in this unique immune-privileged environment throughout life. Multiple immune mechanisms, which we collectively refer to as microglial checkpoints, ensure efficient and tightly regulated microglial responses to perturbations in ...
Aleksandra Deczkowska, Ido Amit, Michal Schwartz   +2 more
openaire   +2 more sources

Immune checkpoint inhibitor myocarditis

Current Opinion in Cardiology, 2019
The purpose of this study is to summarize and highlight the recent literature regarding immune checkpoint inhibitor myocarditis.The use of immune checkpoint inhibitors, a promising form of immunotherapy, is rapidly increasing in oncology. These drugs have been recently found to cause a fulminant myocarditis associated with a high-case fatality rate ...
Jayant, Raikhelkar, Nir, Uriel
openaire   +2 more sources

Immune checkpoints in sepsis: New hopes and challenges

International Reviews of Immunology, 2021
Sepsis is a life-threatening syndrome with a high incidence and a weighty economic burden. The cytokines storm in the early stage and the state of immunosuppression in the late stage contribute to the mortality of sepsis.
Yan-Cun Liu, Song-Tao Shou, Y. Chai
semanticscholar   +1 more source

Targeting glyco-immune checkpoints for cancer therapy

Expert Opinion on Biological Therapy, 2021
Introduction: Targeting immune checkpoints with antibodies has significantly improved the outcome of cancer patients, but only few patients have long-term benefits from currently used PD-1/PD-L1 and CTLA-4 inhibitors.
M. Manni, H. Läubli
semanticscholar   +1 more source

Immune checkpoints in the tumor microenvironment.

Seminars in Cancer Biology, 2020
Interactions between immune checkpoints (ICs) and their ligands negatively regulate T cell activation pathways involved in physiological immune responses against specific antigens.
S. Toor, V. Sasidharan Nair, J. Decock, E. Elkord   +3 more
semanticscholar   +1 more source