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Immune checkpoint for pregnancy
Seminars in ImmunopathologyA successful pregnancy relies on the precise regulation of the maternal immune system to recognize and tolerate the allogeneic fetus, while simultaneously preventing infection. Immune checkpoint molecules (ICMs), such as programmed death receptor 1 (PD-1), cytotoxic T-lymphocyte antigen 4 (CTLA-4), T cell immunoglobulin, and mucin-domain containing-3 ...
Xiaohui Hu, Siying Lai, Aihua Liao
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Combined Immune Checkpoint Blockade
Seminars in Oncology, 2015There are very few tumor types for which chemotherapy regimens are regularly curative; notable exceptions include testicular cancer and Hodgkin's lymphoma. In both cases combination chemotherapy approaches are required. Thus, it would seem only logical that combination immunotherapy approaches will be required to induce long-term remissions in the ...
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Radiotherapy, immunity, and immune checkpoint inhibitors
The Lancet OncologyRadiotherapy exerts immunostimulatory and immunosuppressive effects, both locally, within the irradiated tumour microenvironment, and systemically, outside the radiation field. Inspired by preclinical data that showed synergy between radiotherapy and immune checkpoint inhibitors, multiple clinical trials were initiated with the hypothesis that combined
Connor, Lynch +2 more
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Immune Checkpoint Inhibitor–Induced Lipodystrophy
JAMA DermatologyThis case series describes lipodystrophy, a rare adverse event associated with immune checkpoint inhibitor therapy.
Riganti J. +15 more
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2017
Tumor cell transformation prompts to activation of adaptive and innate immune responses, which had a crucial role in eliminating and controlling early cancer growth. Over the past 10 years, there has been a greater understanding of the immune response to tumors which has led to the development of a huge number of immunotherapeutic strategies [1, 2 ...
Angela Esposito, Giuseppe Curigliano
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Tumor cell transformation prompts to activation of adaptive and innate immune responses, which had a crucial role in eliminating and controlling early cancer growth. Over the past 10 years, there has been a greater understanding of the immune response to tumors which has led to the development of a huge number of immunotherapeutic strategies [1, 2 ...
Angela Esposito, Giuseppe Curigliano
openaire +1 more source
2018
Immune checkpoint inhibitors (ICI) represent a class of immuno-oncology drugs consisting of monoclonal antibodies occurring against inhibitory receptors or ligands within the immune system including CTLA-4, PD-1, and PD-L1. ICI has transformed oncology in the last decade leading to increased response rates and improved overall survival across several ...
Sarah Sammons +3 more
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Immune checkpoint inhibitors (ICI) represent a class of immuno-oncology drugs consisting of monoclonal antibodies occurring against inhibitory receptors or ligands within the immune system including CTLA-4, PD-1, and PD-L1. ICI has transformed oncology in the last decade leading to increased response rates and improved overall survival across several ...
Sarah Sammons +3 more
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International Immunopharmacology, 2021
Leila Mohamed Khosroshahi +4 more
semanticscholar +1 more source
Leila Mohamed Khosroshahi +4 more
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Checkpoints in antibacterial immunity
Research in Immunology, 1998Flesch, I. +3 more
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