Results 41 to 50 of about 3,908,577 (301)

Real-time imaging of resident T cells in human lung and ovarian carcinomas reveals how different tumor microenvironments control T lymphocyte migration

Frontiers in Immunology, 2015
T cells play a key role in the battle against cancer. To perform their antitumor activities, T cells need to adequately respond to tumor antigens by establishing contact with either malignant cells or antigen-presenting cells. These latter functions rely
Houcine eBougherara, Audrey eMansuet-Lupo, Marco eAlifano, Charlotte eNgô, Diane eDamotte, Marie-Aude eLe Frère-Belda, Emmanuel eDonnadieu, Elisa ePeranzoni   +7 more
doaj   +1 more source

Salmonella Virulence and Immune Escape

Microorganisms, 2020
Salmonella genus represents the most common foodborne pathogens causing morbidity, mortality, and burden of disease in all regions of the world. The introduction of antimicrobial agents and Salmonella-specific phages has been considered as an effective ...
Mengyao Wang, Izhar Hyder Qazi, Linli Wang, Guangbin Zhou, Hongbing Han   +4 more
doaj   +1 more source

Abrine, an IDO1 inhibitor, suppresses the immune escape and enhances the immunotherapy of anti-PD-1 antibody in hepatocellular carcinoma

Frontiers in Immunology, 2023
Background Indoleamine-2,3-dioxygenase 1 (IDO1) is responsible for tumor immune escape by regulating T cell-associated immune responses and promoting the activation of immunosuppressive.
Xiaowei Liang, Hong-Wei Gao, Jian Xiao, Shan Han, Jia He, Renyikun Yuan, Shilin Yang, Chun Yao   +7 more
semanticscholar   +1 more source

Constrained pattern of viral evolution in acute and early HCV infection limits viral plasticity [PDF]

, 2011
Cellular immune responses during acute Hepatitis C virus (HCV) and HIV infection are a known correlate of infection outcome. Viral adaptation to these responses via mutation(s) within CD8+ T-cell epitopes allows these viruses to subvert host immune ...
Paul Klenerman, Malte Heeg, John, Mina, Pfafferott, K, James, Ian, Ulsenheimer, Axel, Helmut M. Diepolder, Lucas, A.D., Silvana Gaudieri, Heeg, M, Rauch, A, Ian James, John, M., Andri Rauch, Klenerman, P., James, I, Simon Mallal, Diepolder, HM, Heeg, Malte, John, M, Mallal, Simon, Lucas, Andrew, Nolan, D., Lucas, M., Heeg, M., Michaela Lucas, Diepolder, H.M., Mallal, S., Gaudieri, S, Lucas, M, Gaudieri, S., Nolan, David, Ulsenheimer, A, Lucas, A, David Nolan, Klenerman, Paul, Diepolder, Helmut M., Pfafferott, K., Klenerman, P, Rauch, A., Ulsenheimer, A., Pfafferott, Katja, Lucas, Michaela, Katja Pfafferott, Andrew Lucas, Rauch, Andri, Diepolder, Helmut M, Axel Ulsenheimer, Mina John, Helmut M Diepolder, Nolan, D, Mallal, S, James, I., Gaudieri, Silvana   +53 more
core   +3 more sources

Realistic Earth escape strategies for solar sailing [PDF]

, 2005
With growing interest in solar sailing comes the requirement to provide a basis for future detailed planetary escape mission analysis by drawing together prior work, clarifying and explaining previously anomalies.
Macdonald, Malcolm, McInnes, Colin R.
core   +4 more sources

SARS-CoV-2 prolonged infection during advanced HIV disease evolves extensive immune escape

Cell Host and Microbe, 2022
Summary Characterizing SARS-CoV-2 evolution in specific geographies may help predict properties of the variants that come from these regions. We mapped neutralization of a SARS-CoV-2 strain that evolved over 6 months from ancestral virus in a person with
S. Cele, F. Karim, G. Lustig, J. E. San, Tandile Hermanus, H. Tegally, J. Snyman, T. Moyo-Gwete, E. Wilkinson, M. Bernstein, K. Khan, S. Hwa, Sasha W. Tilles, Lavanya Singh, J. Giandhari, N. Mthabela, M. Mazibuko, Y. Ganga, B. Gosnell, S. Abdool Karim, W. Hanekom, W. Van Voorhis, T. Ndung'u, R. Lessells, P. Moore, M. Moosa, T. de Oliveira, A. Sigal   +27 more
semanticscholar   +1 more source

DNA alteration‐based classification of uveal melanoma gives better prognostic stratification than immune infiltration, which has a neutral effect in high‐risk group

Cancer Medicine, 2019
Background In uveal melanomas, immune infiltration is a marker of poor prognosis. This work intended to decipher the biological characteristics of intra‐tumor immune population, compare it to other established biomarkers and to patients' outcome. Methods
Deepti Narasimhaiah, Catherine Legrand, Diane Damotte, Romain Remark, Marco Munda, Patrick De Potter, Pierre G. Coulie, Miikka Vikkula, Catherine Godfraind   +8 more
doaj   +1 more source

Immune escape and resistance to immunotherapy in mismatch repair deficient tumors

Frontiers in Immunology, 2023
Up to 30% of colorectal, endometrial and gastric cancers have a deficiency in mismatch repair (MMR) protein expression due to either germline or epigenetic inactivation.
G. Mestrallet, Matthew D. Brown, C. C. Bozkus, N. Bhardwaj   +3 more
semanticscholar   +1 more source

Efferocytosis: An accomplice of cancer immune escape.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023
The clearance of apoptotic cells by efferocytes such as macrophages and dendritic cells is termed as "efferocytosis", it plays critical roles in maintaining tissue homeostasis in multicellular organisms.
Hui Qiu, Zhiying Shao, Xin Wen, Zhengyang Liu, Ziqin Chen, Debao Qu, Xin Ding, Long-Zhen Zhang   +7 more
semanticscholar   +1 more source

Molecular Analysis of Immune-Escape Mutants of Hepatitis B Virus from Local Clinical Samples

Microbiology Indonesia, 2012
Small hepatitis B surface antigen (sHBsAg) is used as a component of hepatitis B vaccine. Even though this vaccine is known to be effective in preventing hepatitis B disease, natural mutation may induce Hepatitis B Virus (HBV) to form immune-escape ...
CHANDRA JINATA, ERNAWATI ARIFIN GIRI-RACHMAN, DEBBIE SOEFIE RETNONINGRUM   +2 more
doaj   +1 more source