Results 31 to 40 of about 3,908,577 (301)

The significant immune escape of pseudotyped SARS-CoV-2 variant Omicron

Emerging Microbes and Infections, 2021
The emergence of Omicron/BA.1 has brought new challenges to fight against SARS-CoV-2. A large number of mutations in the Spike protein suggest that its susceptibility to immune protection elicited by the existing COVID-19 infection and vaccines may be ...
Li Zhang, Qianqian Li, Ziteng Liang, Taojing Li, Shuo Liu, Qianqian Cui, Jian-Hui Nie, Qian Wu, X. Qu, Wei-Jing Huang, You-Chun Wang   +10 more
semanticscholar   +1 more source

De Novo generation of escape Variant-specific CD8+ T-Cell responses following Cytotoxic T-Lymphocyte escape in chronic Human Immunodeficiency Virus Type 1 Infection [PDF]

, 2005
Human immunodeficiency virus type 1 (HIV-1) evades CD8+ T-cell responses through mutations within targeted epitopes, but little is known regarding its ability to generate de novo CD8+ T-cell responses to such mutants.
Allgaier, R.L., Cheng, M., Galit Alter, Altfeld, M., Elizabeth T. Kalife, Frahm, N., Xu G. Yu, Kalife, E.T., Marcus Altfeld, Michael Cheng, Yu, X.G., Walker, B.D., Laura L. Reyor, Mui, S., Allen, T.M., Reyor, L.L., Christian Brander, Alter, G., Mathias Lichterfeld, Eric S. Rosenberg, Rachel L. Allgaier, Todd M. Allen, Simon A. Mallal, Nancy V. Brown, John, M., Nicole Frahm, Johnston, M.N., Rosenberg, E.S., Brown, N.V., Brander, C., Bruce D. Walker, Mina John, Mary N. Johnston, Mallal, S.A., Stanley Mui, Lichterfeld, M.   +35 more
core   +1 more source

Preprint: Mutation Rate Evolution Drives Immune Escape In Mismatch Repair-Deficient Cancer

, 2022
SUMMARY Mutation rate optimisation drives evolution and immune evasion of bacteria and lentiviral strains, including HIV. Whether evolving cancer lineages similarly adapt mutation rates to increase tumour cell fitness is unknown.
Daniel Hochhauser, Hamzeh Kayhanian, Panagiotis Barmpoutis, Luis Zapata, Trevor Graham, Andrea Sottoriva, Christopher Steele, Chen Jin, Manuel Rodriguez-Justo, Naomi Guppy, Eszter Lakatos, Daniel Alexander, Marjolijn J.L. Ligtenberg, Kevin Litchfield, Khurum Khan, Iris D. Nagtegaal, Nischalan Pillay, Genomics England Research Consortium, William Waddingham, Giulio Caravagna, Marco Novelli, Kai-Keen Shiu, William Cross, Benjamin Werner, Christopher Ross, Salvatore Milite, Marnix Jansen, Dominic Patel, Ann-Marie Baker, Josep Linares   +29 more
core   +1 more source

Extracellular vesicles in pancreatic cancer immune escape: Emerging roles and mechanisms

Pharmacological Research, 2022
Pancreatic cancer (PC) is the most lethal malignancy worldwide due to its delayed diagnosis and limited treatment options. Despite great progress in clinical trials of immunotherapies for various cancers, their effectiveness in PC is very low, indicating
Chunping Liu, Dongyue He, Longmei Li, Shihui Zhang, Lei Wang, Zhijin Fan, Yichao Wang   +6 more
doaj   +1 more source

PLA2G2A+ cancer-associated fibroblasts mediate pancreatic cancer immune escape via impeding antitumor immune response of CD8+ cytotoxic T cells.

Cancer Letters, 2023
Our previous research defined a novel metabolic cancer associated fibroblasts subset (meCAFs) enriched in loose-type pancreatic ductal adenocarcinoma (PDAC) and related toCD8+ T cells accumulation.
Weiyu Ge, Ming Yue, R. Lin, Tianhao Zhou, Haiyan Xu, T. Mao, Shumin Li, Xiu-Qi Wu, Xiao-Fei Zhang, Yong-Chao Wang, Jingyu Ma, Yan-Ling Wang, S. Xue, Daiyuan Shentu, Jiujie Cui, Li-Wei Wang   +15 more
semanticscholar   +1 more source

Molecular Mechanism of Tumor Cell Immune Escape Mediated by CD24/Siglec-10

Frontiers in Immunology, 2020
Tumor immune escape is an important part of tumorigenesis and development. Tumor cells can develop a variety of immunosuppressive mechanisms to combat tumor immunity.
Shan-Shan Yin, Feng-Hou Gao
doaj   +1 more source

Crosstalk between oxidative phosphorylation and immune escape in cancer: a new concept of therapeutic targets selection

Cellular Oncology, 2023
Background Cancer is increasingly recognized as a metabolic disease, with evidence suggesting that oxidative phosphorylation (OXPHOS) plays a significant role in the progression of numerous cancer cells.
Xutong Qiu, Yi Li, Zhuoyuan Zhang
semanticscholar   +1 more source

Selection of neutralizing antibody escape mutants with type A influenza virus HA-specific polyclonal antisera: possible significance for antigenic drift [PDF]

, 1997
Ten antisera were produced in rabbits by two or three intravenous injections of inactivated whole influenza type A virions. All contained haemagglutination-inhibition (HI) antibody directed predominantly to an epitope in antigenic site B and, in addition,
Cleveland, S. Matthew, Dimmock, N. J., Taylor, H. P.   +2 more
core   +1 more source

Evolution of the SARS‐CoV‐2 omicron variants BA.1 to BA.5: Implications for immune escape and transmission

Reviews in Medical Virology, 2022
The first dominant SARS‐CoV‐2 Omicron variant BA.1 harbours 35 mutations in its Spike protein from the original SARS‐CoV‐2 variant that emerged late 2019.
L. Shrestha, Charles S. P. Foster, W. Rawlinson, N. Tedla, Rowena A. Bull   +4 more
semanticscholar   +1 more source

Human monoclonal antibody combination against SARS coronavirus : synergy and coverage of escape mutants [PDF]

, 2006
Background: Experimental animal data show that protection against severe acute respiratory syndrome coronavirus (SARS-CoV) infection with human monoclonal antibodies (mAbs) is feasible.
Peiris, Joseph S. M., Cox Freek, Doerr, Hans Wilhelm, Brink, Edward van den, van den Brink Edward N, Hans Wilhelm Doerr, ter Meulen Jan, Doerr Hans Wilhelm, Cheung, Chung Y., de Kruif John, van Deventer, Els, Jaap Goudsmit, Leo L. M., Poon, Leo L M Poon, Marissen Wilfred E, Marissen, Wilfred E., Poon Leo L. M, van den Brink, Edward N., Chow Vincent T, Chung Y Cheung, Wolfgang Preiser, Leung, Cynthia S.W., Preiser, Wolfgang, Van Deventer, E, Bogaards Johannes A, Freek Cox, Wilfred E Marissen, Els van Deventer, Joseph S M Peiris, Chow, Tak-Kwong Vincent, Bakker, Arjen Q., Leung, CSW, Chow, Vincent T., de Kruif, John, Goudsmit Jaap, ter Meulen, Jan, Deventer, Els van, Kruif, John de, De Kruif, J, John de Kruif, Cynthia S W Leung, Jan ter Meulen, Bogaards, Johannes A., Cox, F, Preiser Wolfgang, Cox, Freek, Goudsmit, J, Peiris Joseph S. M, Poon, LLM, Cheung, CY, Johannes A Bogaards, Doerr, HW, van Deventer Els, Marissen, WE, Bakker Arjen Q, Peiris, Joseph S.M., Poon, Leo L. M., Leung Cynthia S. W, Chow, VT, Edward N van den Brink, Bogaards, JA, Vincent T Chow, Arjen Q Bakker, Poon, Leo L.M., Cheung Chung Y, Van Den Brink, EN, Peiris, Joseph Sriyal Malik, Ter Meulen, J, Leung, Cynthia S. W., Goudsmit, Jaap, Peiris, JSM, Meulen, Jan ter, Bakker, AQ, Preiser, W   +73 more
core   +1 more source